Cargando…

Acid Adaptation Promotes TRPC1 Plasma Membrane Localization Leading to Pancreatic Ductal Adenocarcinoma Cell Proliferation and Migration through Ca(2+) Entry and Interaction with PI3K/CaM

SIMPLE SUMMARY: Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest cancers globally, with a 5-year overall survival of less than 10%. The development and progression of PDAC are linked to its fluctuating acidic tumor microenvironment. Ion channels act as important sensors of this acidic...

Descripción completa

Detalles Bibliográficos
Autores principales:	Schnipper, Julie, Kouba, Sana, Hague, Frédéric, Girault, Alban, Telliez, Marie-Sophie, Guénin, Stéphanie, Ahidouch, Ahmed, Pedersen, Stine Falsig, Ouadid-Ahidouch, Halima
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9563726/ https://www.ncbi.nlm.nih.gov/pubmed/36230869 http://dx.doi.org/10.3390/cancers14194946

Ejemplares similares

The TRPC1 Channel Forms a PI3K/CaM Complex and Regulates Pancreatic Ductal Adenocarcinoma Cell Proliferation in a Ca(2+)-Independent Manner
por: Schnipper, Julie, et al.
Publicado: (2022)

Crosstalk between Ca(2+) Signaling and Cancer Stemness: The Link to Cisplatin Resistance
por: Kouba, Sana, et al.
Publicado: (2022)

Ion Channel Signature in Healthy Pancreas and Pancreatic Ductal Adenocarcinoma
por: Schnipper, Julie, et al.
Publicado: (2020)

Functional cooperation between KCa3.1 and TRPC1 channels in human breast cancer: Role in cell proliferation and patient prognosis
por: Faouzi, Malika, et al.
Publicado: (2016)

Expression of TRPC6 channels in human epithelial breast cancer cells
por: Guilbert, Arnaud, et al.
Publicado: (2008)

Orai3-Mediates Cisplatin-Resistance in Non-Small Cell Lung Cancer Cells by Enriching Cancer Stem Cell Population through PI3K/AKT Pathway
por: Daya, Hiba Abou, et al.
Publicado: (2021)

K(+) channels and cell cycle progression in tumor cells
por: Ouadid-Ahidouch, Halima, et al.
Publicado: (2013)

Orai3 Constitutes a Native Store-Operated Calcium Entry That Regulates Non Small Cell Lung Adenocarcinoma Cell Proliferation
por: Ay, Anne-Sophie, et al.
Publicado: (2013)

Store-Independent Calcium Entry and Related Signaling Pathways in Breast Cancer
por: Chamlali, Mohamed, et al.
Publicado: (2021)

Inositol 1,4,5-trisphosphate-induced Ca(2+ )signalling is involved in estradiol-induced breast cancer epithelial cell growth
por: Szatkowski, Cécilia, et al.
Publicado: (2010)

Orai3 is a predictive marker of metastasis and survival in resectable lung adenocarcinoma
por: Benzerdjeb, Nazim, et al.
Publicado: (2016)

Downregulation of type 3 inositol (1,4,5)-trisphosphate receptor decreases breast cancer cell migration through an oscillatory Ca(2+) signal
por: Mound, Abdallah, et al.
Publicado: (2017)

Estrogen regulation of TRPM8 expression in breast cancer cells
por: Chodon, Dechen, et al.
Publicado: (2010)

Orai3 Calcium Channel Regulates Breast Cancer Cell Migration through Calcium-Dependent and -Independent Mechanisms
por: Chamlali, Mohamed, et al.
Publicado: (2021)

Original association of ion transporters mediates the ECM-induced breast cancer cell survival: Kv10.1-Orai1-SPCA2 partnership
por: Peretti, Marta, et al.
Publicado: (2019)

Ion Channels: New Actors Playing in Chemotherapeutic Resistance
por: Kischel, Philippe, et al.
Publicado: (2019)

Orai1 Channel Regulates Human-Activated Pancreatic Stellate Cell Proliferation and TGF(β1) Secretion through the AKT Signaling Pathway
por: Radoslavova, Silviya, et al.
Publicado: (2021)

Mechanisms and significance of Ca(2+) entry through TRPC channels
por: Bacsa, Bernadett, et al.
Publicado: (2020)

New Castanospermine Glycoside Analogues Inhibit Breast Cancer Cell Proliferation and Induce Apoptosis without Affecting Normal Cells
por: Allan, Ghada, et al.
Publicado: (2013)

Inositol (1,4,5)-Trisphosphate Receptors in Invasive Breast Cancer: A New Prognostic Tool?
por: Foulon, Arthur, et al.
Publicado: (2022)

TRPC1 channel clustering during store-operated Ca(2+) entry in keratinocytes
por: Manning, Declan, et al.
Publicado: (2023)

TRPM6 is Essential for Magnesium Uptake and Epithelial Cell Function in the Colon
por: Luongo, Francesca, et al.
Publicado: (2018)

TRPM7 Modulates Human Pancreatic Stellate Cell Activation
por: Auwercx, Julie, et al.
Publicado: (2022)

Ablation of TRPC3 disrupts Ca(2+) signaling in salivary ductal cells and promotes sialolithiasis
por: Choi, Bok-Eum, et al.
Publicado: (2023)

The Transient Receptor Potential Melastatin 7 Channel Regulates Pancreatic Cancer Cell Invasion through the Hsp90α/uPA/MMP2 pathway()
por: Rybarczyk, Pierre, et al.
Publicado: (2017)

The Pharmacological and Structural Basis of the AahII–Na(V)1.5 Interaction and Modulation by the Anti-AahII Nb10 Nanobody
por: Hmaidi, Riadh, et al.
Publicado: (2022)

Collagen type 1 promotes survival of human breast cancer cells by overexpressing Kv10.1 potassium and Orai1 calcium channels through DDR1-dependent pathway
por: Badaoui, Mehdi, et al.
Publicado: (2017)

GMP-mediated regulation of cardiovascular Ca(2+ )entry channel TRPC6 and its pathophysiological implications
por: Inoue, Ryuji, et al.
Publicado: (2009)

TRPC1-mediated Ca(2+) entry is essential for the regulation of hypoxia and nutrient depletion-dependent autophagy
por: Sukumaran, P, et al.
Publicado: (2015)

Angiotensin-II-Evoked Ca(2+) Entry in Murine Cardiac Fibroblasts Does Not Depend on TRPC Channels
por: Camacho Londoño, Juan E., et al.
Publicado: (2020)

TRPC1 promotes the genesis and progression of colorectal cancer via activating CaM-mediated PI3K/AKT signaling axis
por: Sun, Yang, et al.
Publicado: (2021)

Ca(2+) entry via TRPC1 is essential for cellular differentiation and modulates secretion via the SNARE complex
por: Schaar, Anne, et al.
Publicado: (2019)

Deletion of TRPC6 Attenuates NMDA Receptor-Mediated Ca(2+) Entry and Ca(2+)-Induced Neurotoxicity Following Cerebral Ischemia and Oxygen-Glucose Deprivation
por: Chen, Jin, et al.
Publicado: (2017)

The Molecular Heterogeneity of Store-Operated Ca(2+) Entry in Vascular Endothelial Cells: The Different roles of Orai1 and TRPC1/TRPC4 Channels in the Transition from Ca(2+)-Selective to Non-Selective Cation Currents
por: Moccia, Francesco, et al.
Publicado: (2023)

The P2X7 receptor regulates cell survival, migration and invasion of pancreatic ductal adenocarcinoma cells
por: Giannuzzo, Andrea, et al.
Publicado: (2015)

Loss of Ca(2+) entry via Orai–TRPC1 induces ER stress, initiating immune activation in macrophages
por: Nascimento Da Conceicao, Viviane, et al.
Publicado: (2019)

Mg(2+) Transporters in Digestive Cancers
por: Auwercx, Julie, et al.
Publicado: (2021)

Reduction of Ca(V) channel activities by Ca(2+)–CaM: inactivation or deactivation?
por: Cui, Jianmin
Publicado: (2010)

Tumour cell blebbing and extracellular vesicle shedding: key role of matrikines and ribosomal protein SA
por: Brassart, Bertrand, et al.
Publicado: (2019)

Local Ca(2+) Entry Via Orai1 Regulates Plasma Membrane Recruitment of TRPC1 and Controls Cytosolic Ca(2+) Signals Required for Specific Cell Functions
por: Cheng, Kwong Tai, et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_o61uvm14l4gh92ol8m39hul2uk