Overcoming high level adenosine-mediated immunosuppression by DZD2269, a potent and selective A2aR antagonist

BACKGROUND: Adenosine is a potent immunosuppressant whose levels in the tumor microenvironment (TME) are often much higher than those in normal tissues. Binding of adenosine to its receptor A2aR activates a cascade of genes and leads to immunosuppression. In addition, immune checkpoint blockage mark...

Descripción completa

Detalles Bibliográficos
Autores principales: Bai, Yu, Zhang, Xin, Zheng, Jie, Liu, Ziyi, Yang, Zhenfan, Zhang, Xiaolin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9563815/
https://www.ncbi.nlm.nih.gov/pubmed/36229853
http://dx.doi.org/10.1186/s13046-022-02511-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9563815/
https://www.ncbi.nlm.nih.gov/pubmed/36229853
http://dx.doi.org/10.1186/s13046-022-02511-1

Ejemplares similares