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Overcoming high level adenosine-mediated immunosuppression by DZD2269, a potent and selective A2aR antagonist
BACKGROUND: Adenosine is a potent immunosuppressant whose levels in the tumor microenvironment (TME) are often much higher than those in normal tissues. Binding of adenosine to its receptor A2aR activates a cascade of genes and leads to immunosuppression. In addition, immune checkpoint blockage mark...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9563815/ https://www.ncbi.nlm.nih.gov/pubmed/36229853 http://dx.doi.org/10.1186/s13046-022-02511-1 |