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Dendritic Cells: The Long and Evolving Road towards Successful Targetability in Cancer
Dendritic cells (DCs) are a unique myeloid cell lineage that play a central role in the priming of the adaptive immune response. As such, they are an attractive target for immune oncology based therapeutic approaches. However, targeting these cells has proven challenging with many studies proving in...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9563837/ https://www.ncbi.nlm.nih.gov/pubmed/36230990 http://dx.doi.org/10.3390/cells11193028 |
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author | Marmonti, Enrica Oliva-Ramirez, Jacqueline Haymaker, Cara |
author_facet | Marmonti, Enrica Oliva-Ramirez, Jacqueline Haymaker, Cara |
author_sort | Marmonti, Enrica |
collection | PubMed |
description | Dendritic cells (DCs) are a unique myeloid cell lineage that play a central role in the priming of the adaptive immune response. As such, they are an attractive target for immune oncology based therapeutic approaches. However, targeting these cells has proven challenging with many studies proving inconclusive or of no benefit in a clinical trial setting. In this review, we highlight the known and unknown about this rare but powerful immune cell. As technologies have expanded our understanding of the complexity of DC development, subsets and response features, we are now left to apply this knowledge to the design of new therapeutic strategies in cancer. We propose that utilization of these technologies through a multiomics approach will allow for an improved directed targeting of DCs in a clinical trial setting. In addition, the DC research community should consider a consensus on subset nomenclature to distinguish new subsets from functional or phenotypic changes in response to their environment. |
format | Online Article Text |
id | pubmed-9563837 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-95638372022-10-15 Dendritic Cells: The Long and Evolving Road towards Successful Targetability in Cancer Marmonti, Enrica Oliva-Ramirez, Jacqueline Haymaker, Cara Cells Review Dendritic cells (DCs) are a unique myeloid cell lineage that play a central role in the priming of the adaptive immune response. As such, they are an attractive target for immune oncology based therapeutic approaches. However, targeting these cells has proven challenging with many studies proving inconclusive or of no benefit in a clinical trial setting. In this review, we highlight the known and unknown about this rare but powerful immune cell. As technologies have expanded our understanding of the complexity of DC development, subsets and response features, we are now left to apply this knowledge to the design of new therapeutic strategies in cancer. We propose that utilization of these technologies through a multiomics approach will allow for an improved directed targeting of DCs in a clinical trial setting. In addition, the DC research community should consider a consensus on subset nomenclature to distinguish new subsets from functional or phenotypic changes in response to their environment. MDPI 2022-09-27 /pmc/articles/PMC9563837/ /pubmed/36230990 http://dx.doi.org/10.3390/cells11193028 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Marmonti, Enrica Oliva-Ramirez, Jacqueline Haymaker, Cara Dendritic Cells: The Long and Evolving Road towards Successful Targetability in Cancer |
title | Dendritic Cells: The Long and Evolving Road towards Successful Targetability in Cancer |
title_full | Dendritic Cells: The Long and Evolving Road towards Successful Targetability in Cancer |
title_fullStr | Dendritic Cells: The Long and Evolving Road towards Successful Targetability in Cancer |
title_full_unstemmed | Dendritic Cells: The Long and Evolving Road towards Successful Targetability in Cancer |
title_short | Dendritic Cells: The Long and Evolving Road towards Successful Targetability in Cancer |
title_sort | dendritic cells: the long and evolving road towards successful targetability in cancer |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9563837/ https://www.ncbi.nlm.nih.gov/pubmed/36230990 http://dx.doi.org/10.3390/cells11193028 |
work_keys_str_mv | AT marmontienrica dendriticcellsthelongandevolvingroadtowardssuccessfultargetabilityincancer AT olivaramirezjacqueline dendriticcellsthelongandevolvingroadtowardssuccessfultargetabilityincancer AT haymakercara dendriticcellsthelongandevolvingroadtowardssuccessfultargetabilityincancer |