Effects of sphingolipid metabolism disorders on endothelial cells

Many cardiovascular disorders, including atherosclerosis, hypertension, coronary heart disease, diabetes, etc., are characterized by endothelial cell dysfunction. Endothelial cell function is closely related to sphingolipid metabolism, and normal sphingolipid metabolism is critical for maintaining e...

Descripción completa

Detalles Bibliográficos
Autores principales: Lai, Yali, Tian, Yue, You, Xintong, Du, Jiangnan, Huang, Jianmei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9563846/
https://www.ncbi.nlm.nih.gov/pubmed/36229882
http://dx.doi.org/10.1186/s12944-022-01701-2
_version_ 1784808499248627712
author Lai, Yali
Tian, Yue
You, Xintong
Du, Jiangnan
Huang, Jianmei
author_facet Lai, Yali
Tian, Yue
You, Xintong
Du, Jiangnan
Huang, Jianmei
author_sort Lai, Yali
collection PubMed
description Many cardiovascular disorders, including atherosclerosis, hypertension, coronary heart disease, diabetes, etc., are characterized by endothelial cell dysfunction. Endothelial cell function is closely related to sphingolipid metabolism, and normal sphingolipid metabolism is critical for maintaining endothelial cell homeostasis. Sphingolipid metabolites or key enzymes in abnormal situation, including sphingosine, ceramide (Cer), sphingosine-1-phosphate (S1P), serine, sphingosine kinase (SPHK), ceramide kinase (Cerk), sphingosine-1-phosphate lyase (S1PL) etc., may have a protective or damaging effect on the function of endothelial cells. This review summarizes the effects of sphingolipid metabolites and key enzymes disordering in sphingolipid metabolism on endothelial cells, offering some insights into further research on the pathogenesis of cardiovascular diseases and corresponding therapeutic targets.
format Online
Article
Text
id pubmed-9563846
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-95638462022-10-15 Effects of sphingolipid metabolism disorders on endothelial cells Lai, Yali Tian, Yue You, Xintong Du, Jiangnan Huang, Jianmei Lipids Health Dis Review Many cardiovascular disorders, including atherosclerosis, hypertension, coronary heart disease, diabetes, etc., are characterized by endothelial cell dysfunction. Endothelial cell function is closely related to sphingolipid metabolism, and normal sphingolipid metabolism is critical for maintaining endothelial cell homeostasis. Sphingolipid metabolites or key enzymes in abnormal situation, including sphingosine, ceramide (Cer), sphingosine-1-phosphate (S1P), serine, sphingosine kinase (SPHK), ceramide kinase (Cerk), sphingosine-1-phosphate lyase (S1PL) etc., may have a protective or damaging effect on the function of endothelial cells. This review summarizes the effects of sphingolipid metabolites and key enzymes disordering in sphingolipid metabolism on endothelial cells, offering some insights into further research on the pathogenesis of cardiovascular diseases and corresponding therapeutic targets. BioMed Central 2022-10-13 /pmc/articles/PMC9563846/ /pubmed/36229882 http://dx.doi.org/10.1186/s12944-022-01701-2 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Lai, Yali
Tian, Yue
You, Xintong
Du, Jiangnan
Huang, Jianmei
Effects of sphingolipid metabolism disorders on endothelial cells
title Effects of sphingolipid metabolism disorders on endothelial cells
title_full Effects of sphingolipid metabolism disorders on endothelial cells
title_fullStr Effects of sphingolipid metabolism disorders on endothelial cells
title_full_unstemmed Effects of sphingolipid metabolism disorders on endothelial cells
title_short Effects of sphingolipid metabolism disorders on endothelial cells
title_sort effects of sphingolipid metabolism disorders on endothelial cells
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9563846/
https://www.ncbi.nlm.nih.gov/pubmed/36229882
http://dx.doi.org/10.1186/s12944-022-01701-2
work_keys_str_mv AT laiyali effectsofsphingolipidmetabolismdisordersonendothelialcells
AT tianyue effectsofsphingolipidmetabolismdisordersonendothelialcells
AT youxintong effectsofsphingolipidmetabolismdisordersonendothelialcells
AT dujiangnan effectsofsphingolipidmetabolismdisordersonendothelialcells
AT huangjianmei effectsofsphingolipidmetabolismdisordersonendothelialcells

Ejemplares similares