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Natural antisense transcripts as drug targets
The recent discovery of vast non-coding RNA-based regulatory networks that can be easily modulated by nucleic acid-based drugs has opened numerous new therapeutic possibilities. Long non-coding RNA, and natural antisense transcripts (NATs) in particular, play a significant role in networks that invo...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9563854/ https://www.ncbi.nlm.nih.gov/pubmed/36250017 http://dx.doi.org/10.3389/fmolb.2022.978375 |
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author | Khorkova, Olga Stahl, Jack Joji, Aswathy Volmar, Claude-Henry Zeier, Zane Wahlestedt, Claes |
author_facet | Khorkova, Olga Stahl, Jack Joji, Aswathy Volmar, Claude-Henry Zeier, Zane Wahlestedt, Claes |
author_sort | Khorkova, Olga |
collection | PubMed |
description | The recent discovery of vast non-coding RNA-based regulatory networks that can be easily modulated by nucleic acid-based drugs has opened numerous new therapeutic possibilities. Long non-coding RNA, and natural antisense transcripts (NATs) in particular, play a significant role in networks that involve a wide variety of disease-relevant biological mechanisms such as transcription, splicing, translation, mRNA degradation and others. Currently, significant efforts are dedicated to harnessing these newly emerging NAT-mediated biological mechanisms for therapeutic purposes. This review will highlight the recent clinical and pre-clinical developments in this field and survey the advances in nucleic acid-based drug technologies that make these developments possible. |
format | Online Article Text |
id | pubmed-9563854 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-95638542022-10-15 Natural antisense transcripts as drug targets Khorkova, Olga Stahl, Jack Joji, Aswathy Volmar, Claude-Henry Zeier, Zane Wahlestedt, Claes Front Mol Biosci Molecular Biosciences The recent discovery of vast non-coding RNA-based regulatory networks that can be easily modulated by nucleic acid-based drugs has opened numerous new therapeutic possibilities. Long non-coding RNA, and natural antisense transcripts (NATs) in particular, play a significant role in networks that involve a wide variety of disease-relevant biological mechanisms such as transcription, splicing, translation, mRNA degradation and others. Currently, significant efforts are dedicated to harnessing these newly emerging NAT-mediated biological mechanisms for therapeutic purposes. This review will highlight the recent clinical and pre-clinical developments in this field and survey the advances in nucleic acid-based drug technologies that make these developments possible. Frontiers Media S.A. 2022-09-27 /pmc/articles/PMC9563854/ /pubmed/36250017 http://dx.doi.org/10.3389/fmolb.2022.978375 Text en Copyright © 2022 Khorkova, Stahl, Joji, Volmar, Zeier and Wahlestedt. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Molecular Biosciences Khorkova, Olga Stahl, Jack Joji, Aswathy Volmar, Claude-Henry Zeier, Zane Wahlestedt, Claes Natural antisense transcripts as drug targets |
title | Natural antisense transcripts as drug targets |
title_full | Natural antisense transcripts as drug targets |
title_fullStr | Natural antisense transcripts as drug targets |
title_full_unstemmed | Natural antisense transcripts as drug targets |
title_short | Natural antisense transcripts as drug targets |
title_sort | natural antisense transcripts as drug targets |
topic | Molecular Biosciences |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9563854/ https://www.ncbi.nlm.nih.gov/pubmed/36250017 http://dx.doi.org/10.3389/fmolb.2022.978375 |
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