Cargando…

Natural antisense transcripts as drug targets

The recent discovery of vast non-coding RNA-based regulatory networks that can be easily modulated by nucleic acid-based drugs has opened numerous new therapeutic possibilities. Long non-coding RNA, and natural antisense transcripts (NATs) in particular, play a significant role in networks that invo...

Descripción completa

Detalles Bibliográficos
Autores principales: Khorkova, Olga, Stahl, Jack, Joji, Aswathy, Volmar, Claude-Henry, Zeier, Zane, Wahlestedt, Claes
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9563854/
https://www.ncbi.nlm.nih.gov/pubmed/36250017
http://dx.doi.org/10.3389/fmolb.2022.978375
_version_ 1784808501208416256
author Khorkova, Olga
Stahl, Jack
Joji, Aswathy
Volmar, Claude-Henry
Zeier, Zane
Wahlestedt, Claes
author_facet Khorkova, Olga
Stahl, Jack
Joji, Aswathy
Volmar, Claude-Henry
Zeier, Zane
Wahlestedt, Claes
author_sort Khorkova, Olga
collection PubMed
description The recent discovery of vast non-coding RNA-based regulatory networks that can be easily modulated by nucleic acid-based drugs has opened numerous new therapeutic possibilities. Long non-coding RNA, and natural antisense transcripts (NATs) in particular, play a significant role in networks that involve a wide variety of disease-relevant biological mechanisms such as transcription, splicing, translation, mRNA degradation and others. Currently, significant efforts are dedicated to harnessing these newly emerging NAT-mediated biological mechanisms for therapeutic purposes. This review will highlight the recent clinical and pre-clinical developments in this field and survey the advances in nucleic acid-based drug technologies that make these developments possible.
format Online
Article
Text
id pubmed-9563854
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-95638542022-10-15 Natural antisense transcripts as drug targets Khorkova, Olga Stahl, Jack Joji, Aswathy Volmar, Claude-Henry Zeier, Zane Wahlestedt, Claes Front Mol Biosci Molecular Biosciences The recent discovery of vast non-coding RNA-based regulatory networks that can be easily modulated by nucleic acid-based drugs has opened numerous new therapeutic possibilities. Long non-coding RNA, and natural antisense transcripts (NATs) in particular, play a significant role in networks that involve a wide variety of disease-relevant biological mechanisms such as transcription, splicing, translation, mRNA degradation and others. Currently, significant efforts are dedicated to harnessing these newly emerging NAT-mediated biological mechanisms for therapeutic purposes. This review will highlight the recent clinical and pre-clinical developments in this field and survey the advances in nucleic acid-based drug technologies that make these developments possible. Frontiers Media S.A. 2022-09-27 /pmc/articles/PMC9563854/ /pubmed/36250017 http://dx.doi.org/10.3389/fmolb.2022.978375 Text en Copyright © 2022 Khorkova, Stahl, Joji, Volmar, Zeier and Wahlestedt. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Molecular Biosciences
Khorkova, Olga
Stahl, Jack
Joji, Aswathy
Volmar, Claude-Henry
Zeier, Zane
Wahlestedt, Claes
Natural antisense transcripts as drug targets
title Natural antisense transcripts as drug targets
title_full Natural antisense transcripts as drug targets
title_fullStr Natural antisense transcripts as drug targets
title_full_unstemmed Natural antisense transcripts as drug targets
title_short Natural antisense transcripts as drug targets
title_sort natural antisense transcripts as drug targets
topic Molecular Biosciences
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9563854/
https://www.ncbi.nlm.nih.gov/pubmed/36250017
http://dx.doi.org/10.3389/fmolb.2022.978375
work_keys_str_mv AT khorkovaolga naturalantisensetranscriptsasdrugtargets
AT stahljack naturalantisensetranscriptsasdrugtargets
AT jojiaswathy naturalantisensetranscriptsasdrugtargets
AT volmarclaudehenry naturalantisensetranscriptsasdrugtargets
AT zeierzane naturalantisensetranscriptsasdrugtargets
AT wahlestedtclaes naturalantisensetranscriptsasdrugtargets