Metabolic engineering of Escherichia coli BW25113 for the production of 5-Aminolevulinic Acid based on CRISPR/Cas9 mediated gene knockout and metabolic pathway modification

BACKGROUND: 5-Aminolevulinic acid (ALA) recently received much attention due to its potential application in many fields. In this study, an ALA production strain of Escherichia coli was constructed by rational metabolic engineering and stepwise improvement based on known regulatory and metabolic inf...

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Detalles Bibliográficos
Autores principales: Ye, Changchuan, Yang, Yuting, Chen, Xi, Yang, Lijie, Hua, Xia, Yang, Mengjie, Zeng, Xiangfang, Qiao, Shiyan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9563957/
https://www.ncbi.nlm.nih.gov/pubmed/36229878
http://dx.doi.org/10.1186/s13036-022-00307-7

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