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Long Noncoding RNAs and Circular RNAs Regulate AKT and Its Effectors to Control Cell Functions of Cancer Cells

AKT serine-threonine kinase (AKT) and its effectors are essential for maintaining cell proliferation, apoptosis, autophagy, endoplasmic reticulum (ER) stress, mitochondrial morphogenesis (fission/fusion), ferroptosis, necroptosis, DNA damage response (damage and repair), senescence, and migration of...

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Autores principales: Tang, Jen-Yang, Chuang, Ya-Ting, Shiau, Jun-Ping, Yang, Kun-Han, Chang, Fang-Rong, Hou, Ming-Feng, Farooqi, Ammad Ahmad, Chang, Hsueh-Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9563963/
https://www.ncbi.nlm.nih.gov/pubmed/36230902
http://dx.doi.org/10.3390/cells11192940
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author Tang, Jen-Yang
Chuang, Ya-Ting
Shiau, Jun-Ping
Yang, Kun-Han
Chang, Fang-Rong
Hou, Ming-Feng
Farooqi, Ammad Ahmad
Chang, Hsueh-Wei
author_facet Tang, Jen-Yang
Chuang, Ya-Ting
Shiau, Jun-Ping
Yang, Kun-Han
Chang, Fang-Rong
Hou, Ming-Feng
Farooqi, Ammad Ahmad
Chang, Hsueh-Wei
author_sort Tang, Jen-Yang
collection PubMed
description AKT serine-threonine kinase (AKT) and its effectors are essential for maintaining cell proliferation, apoptosis, autophagy, endoplasmic reticulum (ER) stress, mitochondrial morphogenesis (fission/fusion), ferroptosis, necroptosis, DNA damage response (damage and repair), senescence, and migration of cancer cells. Several lncRNAs and circRNAs also regulate the expression of these functions by numerous pathways. However, the impact on cell functions by lncRNAs and circRNAs regulating AKT and its effectors is poorly understood. This review provides comprehensive information about the relationship of lncRNAs and circRNAs with AKT on the cell functions of cancer cells. the roles of several lncRNAs and circRNAs acting on AKT effectors, such as FOXO, mTORC1/2, S6K1/2, 4EBP1, SREBP, and HIF are explored. To further validate the relationship between AKT, AKT effectors, lncRNAs, and circRNAs, more predicted AKT- and AKT effector-targeting lncRNAs and circRNAs were retrieved from the LncTarD and circBase databases. Consistently, using an in-depth literature survey, these AKT- and AKT effector-targeting database lncRNAs and circRNAs were related to cell functions. Therefore, some lncRNAs and circRNAs can regulate several cell functions through modulating AKT and AKT effectors. This review provides insights into a comprehensive network of AKT and AKT effectors connecting to lncRNAs and circRNAs in the regulation of cancer cell functions.
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spelling pubmed-95639632022-10-15 Long Noncoding RNAs and Circular RNAs Regulate AKT and Its Effectors to Control Cell Functions of Cancer Cells Tang, Jen-Yang Chuang, Ya-Ting Shiau, Jun-Ping Yang, Kun-Han Chang, Fang-Rong Hou, Ming-Feng Farooqi, Ammad Ahmad Chang, Hsueh-Wei Cells Review AKT serine-threonine kinase (AKT) and its effectors are essential for maintaining cell proliferation, apoptosis, autophagy, endoplasmic reticulum (ER) stress, mitochondrial morphogenesis (fission/fusion), ferroptosis, necroptosis, DNA damage response (damage and repair), senescence, and migration of cancer cells. Several lncRNAs and circRNAs also regulate the expression of these functions by numerous pathways. However, the impact on cell functions by lncRNAs and circRNAs regulating AKT and its effectors is poorly understood. This review provides comprehensive information about the relationship of lncRNAs and circRNAs with AKT on the cell functions of cancer cells. the roles of several lncRNAs and circRNAs acting on AKT effectors, such as FOXO, mTORC1/2, S6K1/2, 4EBP1, SREBP, and HIF are explored. To further validate the relationship between AKT, AKT effectors, lncRNAs, and circRNAs, more predicted AKT- and AKT effector-targeting lncRNAs and circRNAs were retrieved from the LncTarD and circBase databases. Consistently, using an in-depth literature survey, these AKT- and AKT effector-targeting database lncRNAs and circRNAs were related to cell functions. Therefore, some lncRNAs and circRNAs can regulate several cell functions through modulating AKT and AKT effectors. This review provides insights into a comprehensive network of AKT and AKT effectors connecting to lncRNAs and circRNAs in the regulation of cancer cell functions. MDPI 2022-09-20 /pmc/articles/PMC9563963/ /pubmed/36230902 http://dx.doi.org/10.3390/cells11192940 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Tang, Jen-Yang
Chuang, Ya-Ting
Shiau, Jun-Ping
Yang, Kun-Han
Chang, Fang-Rong
Hou, Ming-Feng
Farooqi, Ammad Ahmad
Chang, Hsueh-Wei
Long Noncoding RNAs and Circular RNAs Regulate AKT and Its Effectors to Control Cell Functions of Cancer Cells
title Long Noncoding RNAs and Circular RNAs Regulate AKT and Its Effectors to Control Cell Functions of Cancer Cells
title_full Long Noncoding RNAs and Circular RNAs Regulate AKT and Its Effectors to Control Cell Functions of Cancer Cells
title_fullStr Long Noncoding RNAs and Circular RNAs Regulate AKT and Its Effectors to Control Cell Functions of Cancer Cells
title_full_unstemmed Long Noncoding RNAs and Circular RNAs Regulate AKT and Its Effectors to Control Cell Functions of Cancer Cells
title_short Long Noncoding RNAs and Circular RNAs Regulate AKT and Its Effectors to Control Cell Functions of Cancer Cells
title_sort long noncoding rnas and circular rnas regulate akt and its effectors to control cell functions of cancer cells
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9563963/
https://www.ncbi.nlm.nih.gov/pubmed/36230902
http://dx.doi.org/10.3390/cells11192940
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