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Macrophage-Mediated Inflammation in Skin Wound Healing

Macrophages are key immune cells that respond to infections, and modulate pathophysiological conditions such as wound healing. By possessing phagocytic activities and through the secretion of cytokines and growth factors, macrophages are pivotal orchestrators of inflammation, fibrosis, and wound rep...

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Autores principales: Hassanshahi, Alireza, Moradzad, Mohammad, Ghalamkari, Saman, Fadaei, Moosa, Cowin, Allison J., Hassanshahi, Mohammadhossein
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9564023/
https://www.ncbi.nlm.nih.gov/pubmed/36230913
http://dx.doi.org/10.3390/cells11192953
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author Hassanshahi, Alireza
Moradzad, Mohammad
Ghalamkari, Saman
Fadaei, Moosa
Cowin, Allison J.
Hassanshahi, Mohammadhossein
author_facet Hassanshahi, Alireza
Moradzad, Mohammad
Ghalamkari, Saman
Fadaei, Moosa
Cowin, Allison J.
Hassanshahi, Mohammadhossein
author_sort Hassanshahi, Alireza
collection PubMed
description Macrophages are key immune cells that respond to infections, and modulate pathophysiological conditions such as wound healing. By possessing phagocytic activities and through the secretion of cytokines and growth factors, macrophages are pivotal orchestrators of inflammation, fibrosis, and wound repair. Macrophages orchestrate the process of wound healing through the transitioning from predominantly pro-inflammatory (M1-like phenotypes), which present early post-injury, to anti-inflammatory (M2-like phenotypes), which appear later to modulate skin repair and wound closure. In this review, different cellular and molecular aspects of macrophage-mediated skin wound healing are discussed, alongside important aspects such as macrophage subtypes, metabolism, plasticity, and epigenetics. We also highlight previous studies demonstrating interactions between macrophages and these factors for optimal wound healing. Understanding and harnessing the activity and capability of macrophages may help to advance new approaches for improving healing of the skin.
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spelling pubmed-95640232022-10-15 Macrophage-Mediated Inflammation in Skin Wound Healing Hassanshahi, Alireza Moradzad, Mohammad Ghalamkari, Saman Fadaei, Moosa Cowin, Allison J. Hassanshahi, Mohammadhossein Cells Review Macrophages are key immune cells that respond to infections, and modulate pathophysiological conditions such as wound healing. By possessing phagocytic activities and through the secretion of cytokines and growth factors, macrophages are pivotal orchestrators of inflammation, fibrosis, and wound repair. Macrophages orchestrate the process of wound healing through the transitioning from predominantly pro-inflammatory (M1-like phenotypes), which present early post-injury, to anti-inflammatory (M2-like phenotypes), which appear later to modulate skin repair and wound closure. In this review, different cellular and molecular aspects of macrophage-mediated skin wound healing are discussed, alongside important aspects such as macrophage subtypes, metabolism, plasticity, and epigenetics. We also highlight previous studies demonstrating interactions between macrophages and these factors for optimal wound healing. Understanding and harnessing the activity and capability of macrophages may help to advance new approaches for improving healing of the skin. MDPI 2022-09-21 /pmc/articles/PMC9564023/ /pubmed/36230913 http://dx.doi.org/10.3390/cells11192953 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Hassanshahi, Alireza
Moradzad, Mohammad
Ghalamkari, Saman
Fadaei, Moosa
Cowin, Allison J.
Hassanshahi, Mohammadhossein
Macrophage-Mediated Inflammation in Skin Wound Healing
title Macrophage-Mediated Inflammation in Skin Wound Healing
title_full Macrophage-Mediated Inflammation in Skin Wound Healing
title_fullStr Macrophage-Mediated Inflammation in Skin Wound Healing
title_full_unstemmed Macrophage-Mediated Inflammation in Skin Wound Healing
title_short Macrophage-Mediated Inflammation in Skin Wound Healing
title_sort macrophage-mediated inflammation in skin wound healing
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9564023/
https://www.ncbi.nlm.nih.gov/pubmed/36230913
http://dx.doi.org/10.3390/cells11192953
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