Cargando…
Macrophage-Mediated Inflammation in Skin Wound Healing
Macrophages are key immune cells that respond to infections, and modulate pathophysiological conditions such as wound healing. By possessing phagocytic activities and through the secretion of cytokines and growth factors, macrophages are pivotal orchestrators of inflammation, fibrosis, and wound rep...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9564023/ https://www.ncbi.nlm.nih.gov/pubmed/36230913 http://dx.doi.org/10.3390/cells11192953 |
_version_ | 1784808539906113536 |
---|---|
author | Hassanshahi, Alireza Moradzad, Mohammad Ghalamkari, Saman Fadaei, Moosa Cowin, Allison J. Hassanshahi, Mohammadhossein |
author_facet | Hassanshahi, Alireza Moradzad, Mohammad Ghalamkari, Saman Fadaei, Moosa Cowin, Allison J. Hassanshahi, Mohammadhossein |
author_sort | Hassanshahi, Alireza |
collection | PubMed |
description | Macrophages are key immune cells that respond to infections, and modulate pathophysiological conditions such as wound healing. By possessing phagocytic activities and through the secretion of cytokines and growth factors, macrophages are pivotal orchestrators of inflammation, fibrosis, and wound repair. Macrophages orchestrate the process of wound healing through the transitioning from predominantly pro-inflammatory (M1-like phenotypes), which present early post-injury, to anti-inflammatory (M2-like phenotypes), which appear later to modulate skin repair and wound closure. In this review, different cellular and molecular aspects of macrophage-mediated skin wound healing are discussed, alongside important aspects such as macrophage subtypes, metabolism, plasticity, and epigenetics. We also highlight previous studies demonstrating interactions between macrophages and these factors for optimal wound healing. Understanding and harnessing the activity and capability of macrophages may help to advance new approaches for improving healing of the skin. |
format | Online Article Text |
id | pubmed-9564023 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-95640232022-10-15 Macrophage-Mediated Inflammation in Skin Wound Healing Hassanshahi, Alireza Moradzad, Mohammad Ghalamkari, Saman Fadaei, Moosa Cowin, Allison J. Hassanshahi, Mohammadhossein Cells Review Macrophages are key immune cells that respond to infections, and modulate pathophysiological conditions such as wound healing. By possessing phagocytic activities and through the secretion of cytokines and growth factors, macrophages are pivotal orchestrators of inflammation, fibrosis, and wound repair. Macrophages orchestrate the process of wound healing through the transitioning from predominantly pro-inflammatory (M1-like phenotypes), which present early post-injury, to anti-inflammatory (M2-like phenotypes), which appear later to modulate skin repair and wound closure. In this review, different cellular and molecular aspects of macrophage-mediated skin wound healing are discussed, alongside important aspects such as macrophage subtypes, metabolism, plasticity, and epigenetics. We also highlight previous studies demonstrating interactions between macrophages and these factors for optimal wound healing. Understanding and harnessing the activity and capability of macrophages may help to advance new approaches for improving healing of the skin. MDPI 2022-09-21 /pmc/articles/PMC9564023/ /pubmed/36230913 http://dx.doi.org/10.3390/cells11192953 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Hassanshahi, Alireza Moradzad, Mohammad Ghalamkari, Saman Fadaei, Moosa Cowin, Allison J. Hassanshahi, Mohammadhossein Macrophage-Mediated Inflammation in Skin Wound Healing |
title | Macrophage-Mediated Inflammation in Skin Wound Healing |
title_full | Macrophage-Mediated Inflammation in Skin Wound Healing |
title_fullStr | Macrophage-Mediated Inflammation in Skin Wound Healing |
title_full_unstemmed | Macrophage-Mediated Inflammation in Skin Wound Healing |
title_short | Macrophage-Mediated Inflammation in Skin Wound Healing |
title_sort | macrophage-mediated inflammation in skin wound healing |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9564023/ https://www.ncbi.nlm.nih.gov/pubmed/36230913 http://dx.doi.org/10.3390/cells11192953 |
work_keys_str_mv | AT hassanshahialireza macrophagemediatedinflammationinskinwoundhealing AT moradzadmohammad macrophagemediatedinflammationinskinwoundhealing AT ghalamkarisaman macrophagemediatedinflammationinskinwoundhealing AT fadaeimoosa macrophagemediatedinflammationinskinwoundhealing AT cowinallisonj macrophagemediatedinflammationinskinwoundhealing AT hassanshahimohammadhossein macrophagemediatedinflammationinskinwoundhealing |