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Hippocampus and temporal pole functional connectivity is associated with age and individual differences in autobiographical memory

Recollection of one’s personal past, or autobiographical memory (AM), varies across individuals and across the life span. This manifests in the amount of episodic content recalled during AM, which may reflect differences in associated functional brain networks. We take an individual differences appr...

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Autores principales: Setton, Roni, Mwilambwe-Tshilobo, Laetitia, Sheldon, Signy, Turner, Gary R., Spreng, R. Nathan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9564102/
https://www.ncbi.nlm.nih.gov/pubmed/36191210
http://dx.doi.org/10.1073/pnas.2203039119
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author Setton, Roni
Mwilambwe-Tshilobo, Laetitia
Sheldon, Signy
Turner, Gary R.
Spreng, R. Nathan
author_facet Setton, Roni
Mwilambwe-Tshilobo, Laetitia
Sheldon, Signy
Turner, Gary R.
Spreng, R. Nathan
author_sort Setton, Roni
collection PubMed
description Recollection of one’s personal past, or autobiographical memory (AM), varies across individuals and across the life span. This manifests in the amount of episodic content recalled during AM, which may reflect differences in associated functional brain networks. We take an individual differences approach to examine resting-state functional connectivity of temporal lobe regions known to coordinate AM content retrieval with the default network (anterior and posterior hippocampus, temporal pole) and test for associations with AM. Multiecho resting-state functional magnetic resonance imaging (fMRI) and autobiographical interviews were collected for 158 younger and 105 older healthy adults. Interviews were scored for internal (episodic) and external (semantic) details. Age group differences in connectivity profiles revealed that older adults had lower connectivity within anterior hippocampus, posterior hippocampus, and temporal pole but greater connectivity with regions across the default network compared with younger adults. This pattern was positively related to posterior hippocampal volumes in older adults, which were smaller than younger adult volumes. Connectivity associations with AM showed two significant patterns. The first dissociated connectivity related to internal vs. external AM across participants. Internal AM was related to anterior hippocampus and temporal pole connectivity with orbitofrontal cortex and connectivity within posterior hippocampus. External AM was related to temporal pole connectivity with regions across the lateral temporal cortex. In the second pattern, younger adults displayed temporal pole connectivity with regions throughout the default network associated with more detailed AMs overall. Our findings provide evidence for discrete ensembles of brain regions that scale with systematic variation in recollective styles across the healthy adult life span.
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spelling pubmed-95641022023-04-03 Hippocampus and temporal pole functional connectivity is associated with age and individual differences in autobiographical memory Setton, Roni Mwilambwe-Tshilobo, Laetitia Sheldon, Signy Turner, Gary R. Spreng, R. Nathan Proc Natl Acad Sci U S A Biological Sciences Recollection of one’s personal past, or autobiographical memory (AM), varies across individuals and across the life span. This manifests in the amount of episodic content recalled during AM, which may reflect differences in associated functional brain networks. We take an individual differences approach to examine resting-state functional connectivity of temporal lobe regions known to coordinate AM content retrieval with the default network (anterior and posterior hippocampus, temporal pole) and test for associations with AM. Multiecho resting-state functional magnetic resonance imaging (fMRI) and autobiographical interviews were collected for 158 younger and 105 older healthy adults. Interviews were scored for internal (episodic) and external (semantic) details. Age group differences in connectivity profiles revealed that older adults had lower connectivity within anterior hippocampus, posterior hippocampus, and temporal pole but greater connectivity with regions across the default network compared with younger adults. This pattern was positively related to posterior hippocampal volumes in older adults, which were smaller than younger adult volumes. Connectivity associations with AM showed two significant patterns. The first dissociated connectivity related to internal vs. external AM across participants. Internal AM was related to anterior hippocampus and temporal pole connectivity with orbitofrontal cortex and connectivity within posterior hippocampus. External AM was related to temporal pole connectivity with regions across the lateral temporal cortex. In the second pattern, younger adults displayed temporal pole connectivity with regions throughout the default network associated with more detailed AMs overall. Our findings provide evidence for discrete ensembles of brain regions that scale with systematic variation in recollective styles across the healthy adult life span. National Academy of Sciences 2022-10-03 2022-10-11 /pmc/articles/PMC9564102/ /pubmed/36191210 http://dx.doi.org/10.1073/pnas.2203039119 Text en Copyright © 2022 the Author(s). Published by PNAS. https://creativecommons.org/licenses/by-nc-nd/4.0/This article is distributed under Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0 (CC BY-NC-ND) (https://creativecommons.org/licenses/by-nc-nd/4.0/) .
spellingShingle Biological Sciences
Setton, Roni
Mwilambwe-Tshilobo, Laetitia
Sheldon, Signy
Turner, Gary R.
Spreng, R. Nathan
Hippocampus and temporal pole functional connectivity is associated with age and individual differences in autobiographical memory
title Hippocampus and temporal pole functional connectivity is associated with age and individual differences in autobiographical memory
title_full Hippocampus and temporal pole functional connectivity is associated with age and individual differences in autobiographical memory
title_fullStr Hippocampus and temporal pole functional connectivity is associated with age and individual differences in autobiographical memory
title_full_unstemmed Hippocampus and temporal pole functional connectivity is associated with age and individual differences in autobiographical memory
title_short Hippocampus and temporal pole functional connectivity is associated with age and individual differences in autobiographical memory
title_sort hippocampus and temporal pole functional connectivity is associated with age and individual differences in autobiographical memory
topic Biological Sciences
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9564102/
https://www.ncbi.nlm.nih.gov/pubmed/36191210
http://dx.doi.org/10.1073/pnas.2203039119
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