Cargando…
Targeting JWA for Cancer Therapy: Functions, Mechanisms and Drug Discovery
SIMPLE SUMMARY: JWA has been identified as a potential therapeutic target for several cancers. In this review, we summarize the tumor suppressive functions of the JWA gene and its role in anti-cancer drug development. The focus is on elucidating the key regulatory proteins up and downstream of JWA a...
Autores principales: | Ding, Kun, Liu, Xia, Wang, Luman, Zou, Lu, Jiang, Xuqian, Li, Aiping, Zhou, Jianwei |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9564207/ https://www.ncbi.nlm.nih.gov/pubmed/36230577 http://dx.doi.org/10.3390/cancers14194655 |
Ejemplares similares
-
JAC4 Inhibits EGFR-Driven Lung Adenocarcinoma Growth and Metastasis through CTBP1-Mediated JWA/AMPK/NEDD4L/EGFR Axis
por: Ding, Kun, et al.
Publicado: (2023) -
JAC4 Protects from X-ray Radiation-Induced Intestinal Injury by JWA-Mediated Anti-Oxidation/Inflammation Signaling
por: Zhou, Yan, et al.
Publicado: (2022) -
Jwa participates the maintenance of intestinal epithelial homeostasis via ERK/FBXW7-mediated NOTCH1/PPARγ/STAT5 axis and acts as a novel putative aging related gene
por: Li, Xiong, et al.
Publicado: (2022) -
Astrocytic JWA deletion exacerbates dopaminergic neurodegeneration by decreasing glutamate transporters in mice
por: Wang, Rihua, et al.
Publicado: (2018) -
JAC1 targets YY1 mediated JWA/p38 MAPK signaling to inhibit proliferation and induce apoptosis in TNBC
por: Zhai, Zurong, et al.
Publicado: (2022)