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Maternal and fetal serum concentrations of magnesium after administration of a 6‐g bolus dose of magnesium sulfate (MgSO(4) ) to women with imminent preterm delivery
INTRODUCTION: Magnesium sulfate is used world‐wide to treat pregnant women at imminent risk of preterm delivery in order to protect the brain of the premature infant. Previous research has shown that magnesium sulfate decreases the risk of cerebral palsy by ~30% in infants born preterm. Despite this...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9564565/ https://www.ncbi.nlm.nih.gov/pubmed/35501953 http://dx.doi.org/10.1111/aogs.14372 |
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author | Jonsdotter, Andrea Rocha‐Ferreira, Eridan Hagberg, Henrik Carlsson, Ylva |
author_facet | Jonsdotter, Andrea Rocha‐Ferreira, Eridan Hagberg, Henrik Carlsson, Ylva |
author_sort | Jonsdotter, Andrea |
collection | PubMed |
description | INTRODUCTION: Magnesium sulfate is used world‐wide to treat pregnant women at imminent risk of preterm delivery in order to protect the brain of the premature infant. Previous research has shown that magnesium sulfate decreases the risk of cerebral palsy by ~30% in infants born preterm. Despite this, the dosage required for optimal neuroprotection remains unknown. We aimed to investigate whether 6 g magnesium sulfate given as a single bolus dose was tolerable for the women and infants and whether the desired target concentration in the mother's blood was reached and non‐toxic level in the infant could be ensured. MATERIAL AND METHODS: In total, 49 women who were at risk of delivery prior to 32 weeks of gestation were recruited. They received a bolus dose of 6 g magnesium sulfate intravenously between 1 and 24 h prior to giving birth and were closely monitored during and after infusion. Blood samples from the patients were analyzed at different time‐points (20–30 min after start of infusion, 1, 2, 6 and 24 h) post‐administration. Blood samples from the umbilical cord were also taken directly after birth to assess the concentration of magnesium in the infant. RESULTS: None of the women who received magnesium sulfate reached serum magnesium concentrations >3.3 mmol/L. In all, 72% of the women showed serum magnesium levels within the therapeutic interval (2.0–3.5 mmol/L) and no adverse events were observed during the infusion. The serum magnesium levels in the mothers declined to pre‐bolus‐levels within 24 h after delivery. Serum magnesium levels in the umbilical cord samples ranged from 0.87 to 1.4 mmol/L, which means that all but two were within the normal expected range for a newborn premature infant. CONCLUSIONS: A bolus dose of 6 g magnesium sulfate was well tolerated and without any serious side effects in either mother or infant. Most of our women reached the targeted concentration range of serum magnesium levels after infusion was completed. Their infants had magnesium levels within acceptable levels, regardless of gestational week or mother's body mass index. |
format | Online Article Text |
id | pubmed-9564565 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-95645652022-12-06 Maternal and fetal serum concentrations of magnesium after administration of a 6‐g bolus dose of magnesium sulfate (MgSO(4) ) to women with imminent preterm delivery Jonsdotter, Andrea Rocha‐Ferreira, Eridan Hagberg, Henrik Carlsson, Ylva Acta Obstet Gynecol Scand Pregnancy INTRODUCTION: Magnesium sulfate is used world‐wide to treat pregnant women at imminent risk of preterm delivery in order to protect the brain of the premature infant. Previous research has shown that magnesium sulfate decreases the risk of cerebral palsy by ~30% in infants born preterm. Despite this, the dosage required for optimal neuroprotection remains unknown. We aimed to investigate whether 6 g magnesium sulfate given as a single bolus dose was tolerable for the women and infants and whether the desired target concentration in the mother's blood was reached and non‐toxic level in the infant could be ensured. MATERIAL AND METHODS: In total, 49 women who were at risk of delivery prior to 32 weeks of gestation were recruited. They received a bolus dose of 6 g magnesium sulfate intravenously between 1 and 24 h prior to giving birth and were closely monitored during and after infusion. Blood samples from the patients were analyzed at different time‐points (20–30 min after start of infusion, 1, 2, 6 and 24 h) post‐administration. Blood samples from the umbilical cord were also taken directly after birth to assess the concentration of magnesium in the infant. RESULTS: None of the women who received magnesium sulfate reached serum magnesium concentrations >3.3 mmol/L. In all, 72% of the women showed serum magnesium levels within the therapeutic interval (2.0–3.5 mmol/L) and no adverse events were observed during the infusion. The serum magnesium levels in the mothers declined to pre‐bolus‐levels within 24 h after delivery. Serum magnesium levels in the umbilical cord samples ranged from 0.87 to 1.4 mmol/L, which means that all but two were within the normal expected range for a newborn premature infant. CONCLUSIONS: A bolus dose of 6 g magnesium sulfate was well tolerated and without any serious side effects in either mother or infant. Most of our women reached the targeted concentration range of serum magnesium levels after infusion was completed. Their infants had magnesium levels within acceptable levels, regardless of gestational week or mother's body mass index. John Wiley and Sons Inc. 2022-05-02 /pmc/articles/PMC9564565/ /pubmed/35501953 http://dx.doi.org/10.1111/aogs.14372 Text en © 2022 The Authors. Acta Obstetricia et Gynecologica Scandinavica published by John Wiley & Sons Ltd on behalf of Nordic Federation of Societies of Obstetrics and Gynecology (NFOG). https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made. |
spellingShingle | Pregnancy Jonsdotter, Andrea Rocha‐Ferreira, Eridan Hagberg, Henrik Carlsson, Ylva Maternal and fetal serum concentrations of magnesium after administration of a 6‐g bolus dose of magnesium sulfate (MgSO(4) ) to women with imminent preterm delivery |
title | Maternal and fetal serum concentrations of magnesium after administration of a 6‐g bolus dose of magnesium sulfate (MgSO(4)
) to women with imminent preterm delivery |
title_full | Maternal and fetal serum concentrations of magnesium after administration of a 6‐g bolus dose of magnesium sulfate (MgSO(4)
) to women with imminent preterm delivery |
title_fullStr | Maternal and fetal serum concentrations of magnesium after administration of a 6‐g bolus dose of magnesium sulfate (MgSO(4)
) to women with imminent preterm delivery |
title_full_unstemmed | Maternal and fetal serum concentrations of magnesium after administration of a 6‐g bolus dose of magnesium sulfate (MgSO(4)
) to women with imminent preterm delivery |
title_short | Maternal and fetal serum concentrations of magnesium after administration of a 6‐g bolus dose of magnesium sulfate (MgSO(4)
) to women with imminent preterm delivery |
title_sort | maternal and fetal serum concentrations of magnesium after administration of a 6‐g bolus dose of magnesium sulfate (mgso(4)
) to women with imminent preterm delivery |
topic | Pregnancy |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9564565/ https://www.ncbi.nlm.nih.gov/pubmed/35501953 http://dx.doi.org/10.1111/aogs.14372 |
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