Cargando…

Nontyphoidal Salmonella Infection Associated with Subsequent Risk of Hematological Malignancies: A Nationwide Population-Based Cohort Study

This study aimed to investigate the relationship between nontyphoidal salmonellosis (NTS) and new-onset hematological malignancy. We conducted a 17-year nationwide, population-based, retrospective cohort study to examine the association between NTS and the risk of hematological malignancies by using...

Descripción completa

Detalles Bibliográficos
Autores principales: Yun, Chih-Hui, Kao, Wei-Chun, Hsu, Chung Y., Chang, Renin, Cheng, Ming-Fang, Hung, Yao-Min
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9565030/
https://www.ncbi.nlm.nih.gov/pubmed/36232242
http://dx.doi.org/10.3390/ijerph191912943
_version_ 1784808790662578176
author Yun, Chih-Hui
Kao, Wei-Chun
Hsu, Chung Y.
Chang, Renin
Cheng, Ming-Fang
Hung, Yao-Min
author_facet Yun, Chih-Hui
Kao, Wei-Chun
Hsu, Chung Y.
Chang, Renin
Cheng, Ming-Fang
Hung, Yao-Min
author_sort Yun, Chih-Hui
collection PubMed
description This study aimed to investigate the relationship between nontyphoidal salmonellosis (NTS) and new-onset hematological malignancy. We conducted a 17-year nationwide, population-based, retrospective cohort study to examine the association between NTS and the risk of hematological malignancies by using the Longitudinal Health Insurance Database (LHID) of Taiwan. Participants were enrolled from 2000 to 2015 and were monitored until 2017. We traced the years 1998–2000 to ensure that the cases included were newly diagnosed with NTS. The NTS cohort included 13,790 patients with newly diagnosed NTS between 2000 and 2015. Each patient was propensity score matched at a 1:4 ratio with people without NTS. Cumulative incidence, hazard ratios (HRs), and 95% confidence intervals (CIs) were calculated after adjusting for age, sex, income, urbanization, and medical comorbidities. The adjusted hazard ratio (aHR) of hematological malignancies for NTS patients relative to those without NTS was 1.42 (95% CI 0.91–2.20). In the age subgroup analysis, NTS had a significantly greater risk of hematological malignancies for patients older than 60 (aHR 3.04, 95% CI 1.46–6.34), with an incidence rate of 11.7 per 10,000 person-years. In patients over 60 years of age, a prominent risk of hematological malignancies was observed at a follow-up of more than 3 years after the index date (aHR 3.93, 95% CI 1.60–9.65). A history of NTS is associated with the risk of subsequent hematological malignancies in Taiwanese subjects older than 60.
format Online
Article
Text
id pubmed-9565030
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-95650302022-10-15 Nontyphoidal Salmonella Infection Associated with Subsequent Risk of Hematological Malignancies: A Nationwide Population-Based Cohort Study Yun, Chih-Hui Kao, Wei-Chun Hsu, Chung Y. Chang, Renin Cheng, Ming-Fang Hung, Yao-Min Int J Environ Res Public Health Article This study aimed to investigate the relationship between nontyphoidal salmonellosis (NTS) and new-onset hematological malignancy. We conducted a 17-year nationwide, population-based, retrospective cohort study to examine the association between NTS and the risk of hematological malignancies by using the Longitudinal Health Insurance Database (LHID) of Taiwan. Participants were enrolled from 2000 to 2015 and were monitored until 2017. We traced the years 1998–2000 to ensure that the cases included were newly diagnosed with NTS. The NTS cohort included 13,790 patients with newly diagnosed NTS between 2000 and 2015. Each patient was propensity score matched at a 1:4 ratio with people without NTS. Cumulative incidence, hazard ratios (HRs), and 95% confidence intervals (CIs) were calculated after adjusting for age, sex, income, urbanization, and medical comorbidities. The adjusted hazard ratio (aHR) of hematological malignancies for NTS patients relative to those without NTS was 1.42 (95% CI 0.91–2.20). In the age subgroup analysis, NTS had a significantly greater risk of hematological malignancies for patients older than 60 (aHR 3.04, 95% CI 1.46–6.34), with an incidence rate of 11.7 per 10,000 person-years. In patients over 60 years of age, a prominent risk of hematological malignancies was observed at a follow-up of more than 3 years after the index date (aHR 3.93, 95% CI 1.60–9.65). A history of NTS is associated with the risk of subsequent hematological malignancies in Taiwanese subjects older than 60. MDPI 2022-10-10 /pmc/articles/PMC9565030/ /pubmed/36232242 http://dx.doi.org/10.3390/ijerph191912943 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Yun, Chih-Hui
Kao, Wei-Chun
Hsu, Chung Y.
Chang, Renin
Cheng, Ming-Fang
Hung, Yao-Min
Nontyphoidal Salmonella Infection Associated with Subsequent Risk of Hematological Malignancies: A Nationwide Population-Based Cohort Study
title Nontyphoidal Salmonella Infection Associated with Subsequent Risk of Hematological Malignancies: A Nationwide Population-Based Cohort Study
title_full Nontyphoidal Salmonella Infection Associated with Subsequent Risk of Hematological Malignancies: A Nationwide Population-Based Cohort Study
title_fullStr Nontyphoidal Salmonella Infection Associated with Subsequent Risk of Hematological Malignancies: A Nationwide Population-Based Cohort Study
title_full_unstemmed Nontyphoidal Salmonella Infection Associated with Subsequent Risk of Hematological Malignancies: A Nationwide Population-Based Cohort Study
title_short Nontyphoidal Salmonella Infection Associated with Subsequent Risk of Hematological Malignancies: A Nationwide Population-Based Cohort Study
title_sort nontyphoidal salmonella infection associated with subsequent risk of hematological malignancies: a nationwide population-based cohort study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9565030/
https://www.ncbi.nlm.nih.gov/pubmed/36232242
http://dx.doi.org/10.3390/ijerph191912943
work_keys_str_mv AT yunchihhui nontyphoidalsalmonellainfectionassociatedwithsubsequentriskofhematologicalmalignanciesanationwidepopulationbasedcohortstudy
AT kaoweichun nontyphoidalsalmonellainfectionassociatedwithsubsequentriskofhematologicalmalignanciesanationwidepopulationbasedcohortstudy
AT hsuchungy nontyphoidalsalmonellainfectionassociatedwithsubsequentriskofhematologicalmalignanciesanationwidepopulationbasedcohortstudy
AT changrenin nontyphoidalsalmonellainfectionassociatedwithsubsequentriskofhematologicalmalignanciesanationwidepopulationbasedcohortstudy
AT chengmingfang nontyphoidalsalmonellainfectionassociatedwithsubsequentriskofhematologicalmalignanciesanationwidepopulationbasedcohortstudy
AT hungyaomin nontyphoidalsalmonellainfectionassociatedwithsubsequentriskofhematologicalmalignanciesanationwidepopulationbasedcohortstudy