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One-Pot Synthesis of MnO(x)-SiO(2) Porous Composites as Nanozymes with ROS-Scavenging Properties

The development of nanomaterials that mimic the activity of enzymes is a topic of interest, for the decomposition of reactive oxygen species (ROS). We report the preparation of a novel nanocomposite of MnO(x) needles covered with SiO(2) porous material. The material was prepared in one pot with a tw...

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Autores principales: Garrido, M. Dolores, El Haskouri, Jamal, Marcos, María D., Pérez-Pla, Francisco, Ros-Lis, José Vicente, Amorós, Pedro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9565283/
https://www.ncbi.nlm.nih.gov/pubmed/36234632
http://dx.doi.org/10.3390/nano12193503
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author Garrido, M. Dolores
El Haskouri, Jamal
Marcos, María D.
Pérez-Pla, Francisco
Ros-Lis, José Vicente
Amorós, Pedro
author_facet Garrido, M. Dolores
El Haskouri, Jamal
Marcos, María D.
Pérez-Pla, Francisco
Ros-Lis, José Vicente
Amorós, Pedro
author_sort Garrido, M. Dolores
collection PubMed
description The development of nanomaterials that mimic the activity of enzymes is a topic of interest, for the decomposition of reactive oxygen species (ROS). We report the preparation of a novel nanocomposite of MnO(x) needles covered with SiO(2) porous material. The material was prepared in one pot with a two-step procedure. The material was characterized by EDX, SEM, TEM, XRD, nitrogen adsorption–desorption isotherms, and XPS. The synthesis protocol took advantage of the atrane method, favoring the nucleation and initial growth of manganese oxide needles that remained embedded and homogeneously dispersed in a mesoporous silica matrix. The final composite had a high concentration of Mn (Si/Mn molar ratio of ca. 1). The nanozyme presented bimodal porosity: intraparticle and interparticle association with the surfactant micelles and the gaps between silica particles and MnO(x) needles, respectively. The porosity favored the migration of the reagent to the surface of the catalytic MnO(x). The nanozyme showed very efficient SOD and catalase activities, thus improving other materials previously described. The kinetics were studied in detail, and the reaction mechanisms were proposed. It was shown that silica does not play an innocent role in the case of catalase activity, increasing the reaction rate.
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spelling pubmed-95652832022-10-15 One-Pot Synthesis of MnO(x)-SiO(2) Porous Composites as Nanozymes with ROS-Scavenging Properties Garrido, M. Dolores El Haskouri, Jamal Marcos, María D. Pérez-Pla, Francisco Ros-Lis, José Vicente Amorós, Pedro Nanomaterials (Basel) Article The development of nanomaterials that mimic the activity of enzymes is a topic of interest, for the decomposition of reactive oxygen species (ROS). We report the preparation of a novel nanocomposite of MnO(x) needles covered with SiO(2) porous material. The material was prepared in one pot with a two-step procedure. The material was characterized by EDX, SEM, TEM, XRD, nitrogen adsorption–desorption isotherms, and XPS. The synthesis protocol took advantage of the atrane method, favoring the nucleation and initial growth of manganese oxide needles that remained embedded and homogeneously dispersed in a mesoporous silica matrix. The final composite had a high concentration of Mn (Si/Mn molar ratio of ca. 1). The nanozyme presented bimodal porosity: intraparticle and interparticle association with the surfactant micelles and the gaps between silica particles and MnO(x) needles, respectively. The porosity favored the migration of the reagent to the surface of the catalytic MnO(x). The nanozyme showed very efficient SOD and catalase activities, thus improving other materials previously described. The kinetics were studied in detail, and the reaction mechanisms were proposed. It was shown that silica does not play an innocent role in the case of catalase activity, increasing the reaction rate. MDPI 2022-10-07 /pmc/articles/PMC9565283/ /pubmed/36234632 http://dx.doi.org/10.3390/nano12193503 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Garrido, M. Dolores
El Haskouri, Jamal
Marcos, María D.
Pérez-Pla, Francisco
Ros-Lis, José Vicente
Amorós, Pedro
One-Pot Synthesis of MnO(x)-SiO(2) Porous Composites as Nanozymes with ROS-Scavenging Properties
title One-Pot Synthesis of MnO(x)-SiO(2) Porous Composites as Nanozymes with ROS-Scavenging Properties
title_full One-Pot Synthesis of MnO(x)-SiO(2) Porous Composites as Nanozymes with ROS-Scavenging Properties
title_fullStr One-Pot Synthesis of MnO(x)-SiO(2) Porous Composites as Nanozymes with ROS-Scavenging Properties
title_full_unstemmed One-Pot Synthesis of MnO(x)-SiO(2) Porous Composites as Nanozymes with ROS-Scavenging Properties
title_short One-Pot Synthesis of MnO(x)-SiO(2) Porous Composites as Nanozymes with ROS-Scavenging Properties
title_sort one-pot synthesis of mno(x)-sio(2) porous composites as nanozymes with ros-scavenging properties
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9565283/
https://www.ncbi.nlm.nih.gov/pubmed/36234632
http://dx.doi.org/10.3390/nano12193503
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