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One-Pot Synthesis of MnO(x)-SiO(2) Porous Composites as Nanozymes with ROS-Scavenging Properties
The development of nanomaterials that mimic the activity of enzymes is a topic of interest, for the decomposition of reactive oxygen species (ROS). We report the preparation of a novel nanocomposite of MnO(x) needles covered with SiO(2) porous material. The material was prepared in one pot with a tw...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9565283/ https://www.ncbi.nlm.nih.gov/pubmed/36234632 http://dx.doi.org/10.3390/nano12193503 |
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author | Garrido, M. Dolores El Haskouri, Jamal Marcos, María D. Pérez-Pla, Francisco Ros-Lis, José Vicente Amorós, Pedro |
author_facet | Garrido, M. Dolores El Haskouri, Jamal Marcos, María D. Pérez-Pla, Francisco Ros-Lis, José Vicente Amorós, Pedro |
author_sort | Garrido, M. Dolores |
collection | PubMed |
description | The development of nanomaterials that mimic the activity of enzymes is a topic of interest, for the decomposition of reactive oxygen species (ROS). We report the preparation of a novel nanocomposite of MnO(x) needles covered with SiO(2) porous material. The material was prepared in one pot with a two-step procedure. The material was characterized by EDX, SEM, TEM, XRD, nitrogen adsorption–desorption isotherms, and XPS. The synthesis protocol took advantage of the atrane method, favoring the nucleation and initial growth of manganese oxide needles that remained embedded and homogeneously dispersed in a mesoporous silica matrix. The final composite had a high concentration of Mn (Si/Mn molar ratio of ca. 1). The nanozyme presented bimodal porosity: intraparticle and interparticle association with the surfactant micelles and the gaps between silica particles and MnO(x) needles, respectively. The porosity favored the migration of the reagent to the surface of the catalytic MnO(x). The nanozyme showed very efficient SOD and catalase activities, thus improving other materials previously described. The kinetics were studied in detail, and the reaction mechanisms were proposed. It was shown that silica does not play an innocent role in the case of catalase activity, increasing the reaction rate. |
format | Online Article Text |
id | pubmed-9565283 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-95652832022-10-15 One-Pot Synthesis of MnO(x)-SiO(2) Porous Composites as Nanozymes with ROS-Scavenging Properties Garrido, M. Dolores El Haskouri, Jamal Marcos, María D. Pérez-Pla, Francisco Ros-Lis, José Vicente Amorós, Pedro Nanomaterials (Basel) Article The development of nanomaterials that mimic the activity of enzymes is a topic of interest, for the decomposition of reactive oxygen species (ROS). We report the preparation of a novel nanocomposite of MnO(x) needles covered with SiO(2) porous material. The material was prepared in one pot with a two-step procedure. The material was characterized by EDX, SEM, TEM, XRD, nitrogen adsorption–desorption isotherms, and XPS. The synthesis protocol took advantage of the atrane method, favoring the nucleation and initial growth of manganese oxide needles that remained embedded and homogeneously dispersed in a mesoporous silica matrix. The final composite had a high concentration of Mn (Si/Mn molar ratio of ca. 1). The nanozyme presented bimodal porosity: intraparticle and interparticle association with the surfactant micelles and the gaps between silica particles and MnO(x) needles, respectively. The porosity favored the migration of the reagent to the surface of the catalytic MnO(x). The nanozyme showed very efficient SOD and catalase activities, thus improving other materials previously described. The kinetics were studied in detail, and the reaction mechanisms were proposed. It was shown that silica does not play an innocent role in the case of catalase activity, increasing the reaction rate. MDPI 2022-10-07 /pmc/articles/PMC9565283/ /pubmed/36234632 http://dx.doi.org/10.3390/nano12193503 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Garrido, M. Dolores El Haskouri, Jamal Marcos, María D. Pérez-Pla, Francisco Ros-Lis, José Vicente Amorós, Pedro One-Pot Synthesis of MnO(x)-SiO(2) Porous Composites as Nanozymes with ROS-Scavenging Properties |
title | One-Pot Synthesis of MnO(x)-SiO(2) Porous Composites as Nanozymes with ROS-Scavenging Properties |
title_full | One-Pot Synthesis of MnO(x)-SiO(2) Porous Composites as Nanozymes with ROS-Scavenging Properties |
title_fullStr | One-Pot Synthesis of MnO(x)-SiO(2) Porous Composites as Nanozymes with ROS-Scavenging Properties |
title_full_unstemmed | One-Pot Synthesis of MnO(x)-SiO(2) Porous Composites as Nanozymes with ROS-Scavenging Properties |
title_short | One-Pot Synthesis of MnO(x)-SiO(2) Porous Composites as Nanozymes with ROS-Scavenging Properties |
title_sort | one-pot synthesis of mno(x)-sio(2) porous composites as nanozymes with ros-scavenging properties |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9565283/ https://www.ncbi.nlm.nih.gov/pubmed/36234632 http://dx.doi.org/10.3390/nano12193503 |
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