Preclinical efficacy of the Wnt/β-catenin pathway inhibitor BC2059 for the treatment of desmoid tumors

Mutation in the CTNNB1 gene, leading to a deregulation of the WTN/β-catenin pathway, is a common feature of desmoid tumors (DTs). Many β-catenin inhibitors have recently been tested in clinical studies; however, BC2059 (also referred as Tegavivint), a selective inhibitor of nuclear β-catenin that wo...

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Detalles Bibliográficos
Autores principales: Braggio, Danielle Almeida, Costas C. de Faria, Fernanda, Koller, David, Jin, Feng, Zewdu, Abeba, Lopez, Gonzalo, Batte, Kara, Casadei, Lucia, Welliver, Meng, Horrigan, Stephen K., Han, Ruolan, Larson, Jeffrey L., Strohecker, Anne M., Pollock, Raphael E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9565452/
https://www.ncbi.nlm.nih.gov/pubmed/36240209
http://dx.doi.org/10.1371/journal.pone.0276047

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