ACBP/DBI protein neutralization confers autophagy-dependent organ protection through inhibition of cell loss, inflammation, and fibrosis

Acyl-coenzyme A (CoA)–binding protein (ACBP), also known as diazepam-binding inhibitor (DBI), is an extracellular feedback regulator of autophagy. Here, we report that injection of a monoclonal antibody neutralizing ACBP/DBI (α-DBI) protects the murine liver against ischemia/reperfusion damage, into...

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Detalles Bibliográficos
Autores principales: Motiño, Omar, Lambertucci, Flavia, Anagnostopoulos, Gerasimos, Li, Sijing, Nah, Jihoon, Castoldi, Francesca, Senovilla, Laura, Montégut, Léa, Chen, Hui, Durand, Sylvère, Bourgin, Mélanie, Aprahamian, Fanny, Nirmalathasan, Nitharsshini, Alvarez-Valadez, Karla, Sauvat, Allan, Carbonnier, Vincent, Djavaheri-Mergny, Mojgan, Pietrocola, Federico, Sadoshima, Junichi, Maiuri, Maria Chiara, Martins, Isabelle, Kroemer, Guido
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9565466/
https://www.ncbi.nlm.nih.gov/pubmed/36191214
http://dx.doi.org/10.1073/pnas.2207344119

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