Caspase-8 and FADD prevent spontaneous ZBP1 expression and necroptosis

The absence of Caspase-8 or its adapter, Fas-associated death domain (FADD), results in activation of receptor interacting protein kinase-3 (RIPK3)- and mixed-lineage kinase-like (MLKL)–dependent necroptosis in vivo. Here, we show that spontaneous activation of RIPK3, phosphorylation of MLKL, and ne...

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Detalles Bibliográficos
Autores principales: Rodriguez, Diego A., Quarato, Giovanni, Liedmann, Swantje, Tummers, Bart, Zhang, Ting, Guy, Cliff, Crawford, Jeremy Chase, Palacios, Gustavo, Pelletier, Stephane, Kalkavan, Halime, Shaw, Jeremy J. P., Fitzgerald, Patrick, Chen, Mark J., Balachandran, Siddharth, Green, Douglas R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9565532/
https://www.ncbi.nlm.nih.gov/pubmed/36191211
http://dx.doi.org/10.1073/pnas.2207240119

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