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Orexins and bipolar disorder: A review
INTRODUCTION: Bipolar disorder (BD) is a chronic deteriorating illness which has a strong impact on functionality. In the past few years, orexins have gained importance as possible biomarkers of circadian rhythms, affected in BD. Up to this date, we have not found any bibliographical review evaluati...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cambridge University Press
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9565623/ http://dx.doi.org/10.1192/j.eurpsy.2022.1014 |
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author | Moya Lacasa, C. Gonzalez-Blanco, L. Martinez-Cao, C. Alvarez-Vazquez, C.M. Martin-Gil, E. García Fernández, A. Saiz, P.A. Bobes, J. Garcia-Portilla, M.P. |
author_facet | Moya Lacasa, C. Gonzalez-Blanco, L. Martinez-Cao, C. Alvarez-Vazquez, C.M. Martin-Gil, E. García Fernández, A. Saiz, P.A. Bobes, J. Garcia-Portilla, M.P. |
author_sort | Moya Lacasa, C. |
collection | PubMed |
description | INTRODUCTION: Bipolar disorder (BD) is a chronic deteriorating illness which has a strong impact on functionality. In the past few years, orexins have gained importance as possible biomarkers of circadian rhythms, affected in BD. Up to this date, we have not found any bibliographical review evaluating the association of orexins and BD. OBJECTIVES: To review published literature in relation to the associaton of orexins and BD. METHODS: A bibliographical search was conducted in PubMed. Inclusion criteria were a) the study evaluated orexins in plasma or cerebrospinal fluid, and b) patients with BD were included within the subjects of study. Reference lists of the articles that met inclusion criteria were also examined. RESULTS: Ten articles were retrieved from the initial search. Only three met inclusion criteria and another one was selected from the reference list examination. One study observed significantly higher levels of orexin A in plasma of BD patients versus depression and controls. Other found higher concentration of orexin A of unipolar and bipolar depression versus controls, but this result was not statistically significant. Another one did not find differences in orexin A concentration between mania, depression and controls. The remaining study detected significantly lower concentration of orexin A in BD versus depression, schizophrenia and controls. CONCLUSIONS: Despite being heterogenous, the results point out there are differences in orexin levels in BD when compared to other diagnostic groups or controls. This sets a starting point to focus research on this subject and continue analyzing the role of orexins as biomarkers in BD. DISCLOSURE: No significant relationships. |
format | Online Article Text |
id | pubmed-9565623 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Cambridge University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-95656232022-10-17 Orexins and bipolar disorder: A review Moya Lacasa, C. Gonzalez-Blanco, L. Martinez-Cao, C. Alvarez-Vazquez, C.M. Martin-Gil, E. García Fernández, A. Saiz, P.A. Bobes, J. Garcia-Portilla, M.P. Eur Psychiatry Abstract INTRODUCTION: Bipolar disorder (BD) is a chronic deteriorating illness which has a strong impact on functionality. In the past few years, orexins have gained importance as possible biomarkers of circadian rhythms, affected in BD. Up to this date, we have not found any bibliographical review evaluating the association of orexins and BD. OBJECTIVES: To review published literature in relation to the associaton of orexins and BD. METHODS: A bibliographical search was conducted in PubMed. Inclusion criteria were a) the study evaluated orexins in plasma or cerebrospinal fluid, and b) patients with BD were included within the subjects of study. Reference lists of the articles that met inclusion criteria were also examined. RESULTS: Ten articles were retrieved from the initial search. Only three met inclusion criteria and another one was selected from the reference list examination. One study observed significantly higher levels of orexin A in plasma of BD patients versus depression and controls. Other found higher concentration of orexin A of unipolar and bipolar depression versus controls, but this result was not statistically significant. Another one did not find differences in orexin A concentration between mania, depression and controls. The remaining study detected significantly lower concentration of orexin A in BD versus depression, schizophrenia and controls. CONCLUSIONS: Despite being heterogenous, the results point out there are differences in orexin levels in BD when compared to other diagnostic groups or controls. This sets a starting point to focus research on this subject and continue analyzing the role of orexins as biomarkers in BD. DISCLOSURE: No significant relationships. Cambridge University Press 2022-09-01 /pmc/articles/PMC9565623/ http://dx.doi.org/10.1192/j.eurpsy.2022.1014 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Abstract Moya Lacasa, C. Gonzalez-Blanco, L. Martinez-Cao, C. Alvarez-Vazquez, C.M. Martin-Gil, E. García Fernández, A. Saiz, P.A. Bobes, J. Garcia-Portilla, M.P. Orexins and bipolar disorder: A review |
title | Orexins and bipolar disorder: A review |
title_full | Orexins and bipolar disorder: A review |
title_fullStr | Orexins and bipolar disorder: A review |
title_full_unstemmed | Orexins and bipolar disorder: A review |
title_short | Orexins and bipolar disorder: A review |
title_sort | orexins and bipolar disorder: a review |
topic | Abstract |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9565623/ http://dx.doi.org/10.1192/j.eurpsy.2022.1014 |
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