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Prevalence of hepatitis B virus and immunity status among healthcare workers in Beira City, Mozambique
BACKGROUND: Hepatitis B virus (HBV) infection can be prevented by vaccination. Exposure to blood or body fluids poses a high risk of transmission of HBV in health care workers (HCWs). This study aimed to determine the prevalence of markers of exposure, susceptibility, and protection to HBV infection...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9565706/ https://www.ncbi.nlm.nih.gov/pubmed/36240262 http://dx.doi.org/10.1371/journal.pone.0276283 |
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author | Mabunda, Nédio Vieira, Lúcia Chelene, Imelda Maueia, Cremildo Zicai, Ana Flora Duajá, Ana Chale, Falume Chambal, Lúcia Vubil, Adolfo Augusto, Orvalho |
author_facet | Mabunda, Nédio Vieira, Lúcia Chelene, Imelda Maueia, Cremildo Zicai, Ana Flora Duajá, Ana Chale, Falume Chambal, Lúcia Vubil, Adolfo Augusto, Orvalho |
author_sort | Mabunda, Nédio |
collection | PubMed |
description | BACKGROUND: Hepatitis B virus (HBV) infection can be prevented by vaccination. Exposure to blood or body fluids poses a high risk of transmission of HBV in health care workers (HCWs). This study aimed to determine the prevalence of markers of exposure, susceptibility, and protection to HBV infection in HCWs in Beira, Mozambique. METHODS: A cross-sectional study was conducted between June and August 2020 in Beira City, Mozambique, in HCWs based on self-administered questionnaires and blood samples. Plasma samples were tested for HBV surface antigen (HBsAg), antibodies to HBV core antigen (anti-HBc), antibodies to HBsAg (anti-HBs) and HBV viral load (HBV DNA). RESULTS: Most of the 315 HCWs in the study were nurses (125; 39.7%). Of the HCWs, 5.1% (16; 95% Confidence Interval (CI): 2.9 to 8.1%) were infected by HBV (HBsAg and/or HBV DNA positive). Occult HBV infection (OBI) (HBV DNA positive and HBsAg negative) was found in 0.3% (1; 95% CI: 0.0 to 1.8%) of participants; 27.9% (88; 95% CI: 23.1 to 33.2%) were susceptible (negative for all markers), 6.3% (20; 95% CI: 3.9 to 9.6) were immune due to natural infection (anti-HBs and anti-HBc positive only), while 60% (189; 95% CI: 54.4 to 65.5) were immune due to vaccination (anti-HBs positive only). CONCLUSION: This study showed a high intermediate prevalence of chronic hepatitis B among healthcare workers in Beira City, Central Mozambique, and one-third of healthcare workers were susceptible to HBV infection. There is a need to implement a national hepatitis B screening and vaccination strategy among healthcare workers in Mozambique. |
format | Online Article Text |
id | pubmed-9565706 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-95657062022-10-15 Prevalence of hepatitis B virus and immunity status among healthcare workers in Beira City, Mozambique Mabunda, Nédio Vieira, Lúcia Chelene, Imelda Maueia, Cremildo Zicai, Ana Flora Duajá, Ana Chale, Falume Chambal, Lúcia Vubil, Adolfo Augusto, Orvalho PLoS One Research Article BACKGROUND: Hepatitis B virus (HBV) infection can be prevented by vaccination. Exposure to blood or body fluids poses a high risk of transmission of HBV in health care workers (HCWs). This study aimed to determine the prevalence of markers of exposure, susceptibility, and protection to HBV infection in HCWs in Beira, Mozambique. METHODS: A cross-sectional study was conducted between June and August 2020 in Beira City, Mozambique, in HCWs based on self-administered questionnaires and blood samples. Plasma samples were tested for HBV surface antigen (HBsAg), antibodies to HBV core antigen (anti-HBc), antibodies to HBsAg (anti-HBs) and HBV viral load (HBV DNA). RESULTS: Most of the 315 HCWs in the study were nurses (125; 39.7%). Of the HCWs, 5.1% (16; 95% Confidence Interval (CI): 2.9 to 8.1%) were infected by HBV (HBsAg and/or HBV DNA positive). Occult HBV infection (OBI) (HBV DNA positive and HBsAg negative) was found in 0.3% (1; 95% CI: 0.0 to 1.8%) of participants; 27.9% (88; 95% CI: 23.1 to 33.2%) were susceptible (negative for all markers), 6.3% (20; 95% CI: 3.9 to 9.6) were immune due to natural infection (anti-HBs and anti-HBc positive only), while 60% (189; 95% CI: 54.4 to 65.5) were immune due to vaccination (anti-HBs positive only). CONCLUSION: This study showed a high intermediate prevalence of chronic hepatitis B among healthcare workers in Beira City, Central Mozambique, and one-third of healthcare workers were susceptible to HBV infection. There is a need to implement a national hepatitis B screening and vaccination strategy among healthcare workers in Mozambique. Public Library of Science 2022-10-14 /pmc/articles/PMC9565706/ /pubmed/36240262 http://dx.doi.org/10.1371/journal.pone.0276283 Text en © 2022 Mabunda et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Mabunda, Nédio Vieira, Lúcia Chelene, Imelda Maueia, Cremildo Zicai, Ana Flora Duajá, Ana Chale, Falume Chambal, Lúcia Vubil, Adolfo Augusto, Orvalho Prevalence of hepatitis B virus and immunity status among healthcare workers in Beira City, Mozambique |
title | Prevalence of hepatitis B virus and immunity status among healthcare workers in Beira City, Mozambique |
title_full | Prevalence of hepatitis B virus and immunity status among healthcare workers in Beira City, Mozambique |
title_fullStr | Prevalence of hepatitis B virus and immunity status among healthcare workers in Beira City, Mozambique |
title_full_unstemmed | Prevalence of hepatitis B virus and immunity status among healthcare workers in Beira City, Mozambique |
title_short | Prevalence of hepatitis B virus and immunity status among healthcare workers in Beira City, Mozambique |
title_sort | prevalence of hepatitis b virus and immunity status among healthcare workers in beira city, mozambique |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9565706/ https://www.ncbi.nlm.nih.gov/pubmed/36240262 http://dx.doi.org/10.1371/journal.pone.0276283 |
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