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Workplace Culture and Biomarkers of Health Risk
Workplace culture has been studied for impact on health risk; however, connections with robust biologic markers of health remain to be established. We examined associations between the work environment and urinary levels of catecholamines and their metabolites as biomarkers of sympathetic nervous sy...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9565767/ https://www.ncbi.nlm.nih.gov/pubmed/36231223 http://dx.doi.org/10.3390/ijerph191911920 |
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author | Shuck, Brad Hart, Joy L. Walker, Kandi L. Rai, Jayesh Srivastava, Shweta Srivastava, Sanjay Rai, Shesh Bhatnagar, Aruni Keith, Rachel J. |
author_facet | Shuck, Brad Hart, Joy L. Walker, Kandi L. Rai, Jayesh Srivastava, Shweta Srivastava, Sanjay Rai, Shesh Bhatnagar, Aruni Keith, Rachel J. |
author_sort | Shuck, Brad |
collection | PubMed |
description | Workplace culture has been studied for impact on health risk; however, connections with robust biologic markers of health remain to be established. We examined associations between the work environment and urinary levels of catecholamines and their metabolites as biomarkers of sympathetic nervous system activity, indicative of stress. We recruited participants (n = 219; 2018–2019) from a cardiovascular risk cohort to investigate workplace culture, well-being, and stress. Participants completed seven questionnaires. Urine samples were used to measure catecholamines and their metabolites by LC/MS/MS. Pearson correlation and linear regression models were used after adjusting for demographics and creatinine. Participants reporting higher well-being had lower urinary levels of dopamine, serotonin, and 3-methoxytyramine. Participants reporting a more engaged and more positive workplace had lower levels of dopamine and 3-methoxytyramine. Reported workplace isolation was correlated with higher levels of dopamine and 3-methoxytyramine. Given correlations between catecholamines, we used 3-methoxytyramine for linear regression. In fully adjusted models, in environments with a more positive culture, levels of 3-methoxytyramine remained lower (β = −0.065 ± 0.025, p = 0.01) and indicated a positive association between workplace isolation and 3-methoxytyramine (β = 0.064 ± 0.030, p = 0.04). These findings are consistent with an important relationship between workplace environment and sympathetic nervous system activity. |
format | Online Article Text |
id | pubmed-9565767 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-95657672022-10-15 Workplace Culture and Biomarkers of Health Risk Shuck, Brad Hart, Joy L. Walker, Kandi L. Rai, Jayesh Srivastava, Shweta Srivastava, Sanjay Rai, Shesh Bhatnagar, Aruni Keith, Rachel J. Int J Environ Res Public Health Article Workplace culture has been studied for impact on health risk; however, connections with robust biologic markers of health remain to be established. We examined associations between the work environment and urinary levels of catecholamines and their metabolites as biomarkers of sympathetic nervous system activity, indicative of stress. We recruited participants (n = 219; 2018–2019) from a cardiovascular risk cohort to investigate workplace culture, well-being, and stress. Participants completed seven questionnaires. Urine samples were used to measure catecholamines and their metabolites by LC/MS/MS. Pearson correlation and linear regression models were used after adjusting for demographics and creatinine. Participants reporting higher well-being had lower urinary levels of dopamine, serotonin, and 3-methoxytyramine. Participants reporting a more engaged and more positive workplace had lower levels of dopamine and 3-methoxytyramine. Reported workplace isolation was correlated with higher levels of dopamine and 3-methoxytyramine. Given correlations between catecholamines, we used 3-methoxytyramine for linear regression. In fully adjusted models, in environments with a more positive culture, levels of 3-methoxytyramine remained lower (β = −0.065 ± 0.025, p = 0.01) and indicated a positive association between workplace isolation and 3-methoxytyramine (β = 0.064 ± 0.030, p = 0.04). These findings are consistent with an important relationship between workplace environment and sympathetic nervous system activity. MDPI 2022-09-21 /pmc/articles/PMC9565767/ /pubmed/36231223 http://dx.doi.org/10.3390/ijerph191911920 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Shuck, Brad Hart, Joy L. Walker, Kandi L. Rai, Jayesh Srivastava, Shweta Srivastava, Sanjay Rai, Shesh Bhatnagar, Aruni Keith, Rachel J. Workplace Culture and Biomarkers of Health Risk |
title | Workplace Culture and Biomarkers of Health Risk |
title_full | Workplace Culture and Biomarkers of Health Risk |
title_fullStr | Workplace Culture and Biomarkers of Health Risk |
title_full_unstemmed | Workplace Culture and Biomarkers of Health Risk |
title_short | Workplace Culture and Biomarkers of Health Risk |
title_sort | workplace culture and biomarkers of health risk |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9565767/ https://www.ncbi.nlm.nih.gov/pubmed/36231223 http://dx.doi.org/10.3390/ijerph191911920 |
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