Non-catalytic allostery in α-TAT1 by a phospho-switch drives dynamic microtubule acetylation

Spatiotemporally dynamic microtubule acetylation underlies diverse physiological and pathological events. Despite its ubiquity, the molecular mechanisms that regulate the sole microtubule acetylating agent, α-tubulin-N-acetyltransferase-1 (α-TAT1), remain obscure. Here, we report that dynamic intrac...

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Detalles Bibliográficos
Autores principales: Deb Roy, Abhijit, Gross, Evan G., Pillai, Gayatri S., Seetharaman, Shailaja, Etienne-Manneville, Sandrine, Inoue, Takanari
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9565784/
https://www.ncbi.nlm.nih.gov/pubmed/36222836
http://dx.doi.org/10.1083/jcb.202202100

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9565784/
https://www.ncbi.nlm.nih.gov/pubmed/36222836
http://dx.doi.org/10.1083/jcb.202202100

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