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Cellular shape reinforces niche to stem cell signaling in the small intestine

Niche-derived factors regulate tissue stem cells, but apart from the mechanosensory pathways, the effect of niche geometry is not well understood. We used organoids and bioengineered tissue culture platforms to demonstrate that the conical shape of Lgr5(+) small intestinal stem cells (ISCs) facilita...

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Detalles Bibliográficos
Autores principales:	Pentinmikko, Nalle, Lozano, Rodrigo, Scharaw, Sandra, Andersson, Simon, Englund, Johanna I., Castillo-Azofeifa, David, Gallagher, Aaron, Broberg, Martin, Song, Ki-Young, Sola Carvajal, Agustín, Speidel, Alessondra T., Sundstrom, Michael, Allbritton, Nancy, Stevens, Molly M., Klein, Ophir D., Teixeira, Ana, Katajisto, Pekka
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for the Advancement of Science 2022
Materias:	Biomedicine and Life Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9565803/ https://www.ncbi.nlm.nih.gov/pubmed/36240269 http://dx.doi.org/10.1126/sciadv.abm1847

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