Activated I-BAR IRSp53 clustering controls the formation of VASP-actin–based membrane protrusions

Filopodia are actin-rich membrane protrusions essential for cell morphogenesis, motility, and cancer invasion. How cells control filopodium initiation on the plasma membrane remains elusive. We performed experiments in cellulo, in vitro, and in silico to unravel the mechanism of filopodium initiatio...

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Detalles Bibliográficos
Autores principales: Tsai, Feng-Ching, Henderson, J. Michael, Jarin, Zack, Kremneva, Elena, Senju, Yosuke, Pernier, Julien, Mikhajlov, Oleg, Manzi, John, Kogan, Konstantin, Le Clainche, Christophe, Voth, Gregory A., Lappalainen, Pekka, Bassereau, Patricia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2022
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9565809/
https://www.ncbi.nlm.nih.gov/pubmed/36240267
http://dx.doi.org/10.1126/sciadv.abp8677

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