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Lateral fenestrations in the extracellular domain of the glycine receptor contribute to the main chloride permeation pathway
Glycine receptors (GlyRs) are ligand-gated ion channels mediating signal transduction at chemical synapses. Since the early patch-clamp electrophysiology studies, the details of the ion permeation mechanism have remained elusive. Here, we combine molecular dynamics simulations of a zebrafish GlyR-α1...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Association for the Advancement of Science
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9565810/ https://www.ncbi.nlm.nih.gov/pubmed/36240268 http://dx.doi.org/10.1126/sciadv.adc9340 |