Cargando…

Sexually dimorphic activation of innate antitumor immunity prevents adrenocortical carcinoma development

Unlike most cancers, adrenocortical carcinomas (ACCs) are more frequent in women than in men, but the underlying mechanisms of this sexual dimorphism remain elusive. Here, we show that inactivation of Znrf3 in the mouse adrenal cortex, recapitulating the most frequent alteration in ACC patients, is...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wilmouth, James J., Olabe, Julie, Garcia-Garcia, Diana, Lucas, Cécily, Guiton, Rachel, Roucher-Boulez, Florence, Dufour, Damien, Damon-Soubeyrand, Christelle, Sahut-Barnola, Isabelle, Pointud, Jean-Christophe, Renaud, Yoan, Levasseur, Adrien, Tauveron, Igor, Lefrançois-Martinez, Anne-Marie, Martinez, Antoine, Val, Pierre
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for the Advancement of Science 2022
Materias:	Biomedicine and Life Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9565812/ https://www.ncbi.nlm.nih.gov/pubmed/36240276 http://dx.doi.org/10.1126/sciadv.add0422

Ejemplares similares

Loss of SUMO-specific protease 2 causes isolated glucocorticoid deficiency by blocking adrenal cortex zonal transdifferentiation in mice
por: Dufour, Damien, et al.
Publicado: (2022)

EZH2 cooperates with E2F1 to stimulate expression of genes involved in adrenocortical carcinoma aggressiveness
por: Tabbal, Houda, et al.
Publicado: (2019)

Mouse Models Recapitulating Human Adrenocortical Tumors: What Is Lacking?
por: Leccia, Felicia, et al.
Publicado: (2016)

Loss of LGR4/GPR48 causes severe neonatal salt wasting due to disrupted WNT signaling altering adrenal zonation
por: Lucas, Cécily, et al.
Publicado: (2023)

Cushing's Syndrome and Fetal Features Resurgence in Adrenal Cortex–Specific Prkar1a Knockout Mice
por: Sahut-Barnola, Isabelle, et al.
Publicado: (2010)

Aldo Keto Reductase 1B7 and Prostaglandin F(2α) Are Regulators of Adrenal Endocrine Functions
por: Lambert-Langlais, Sarah, et al.
Publicado: (2009)

PKA inhibits WNT signalling in adrenal cortex zonation and prevents malignant tumour development
por: Drelon, Coralie, et al.
Publicado: (2016)

Differential expression and localisation of TGF-β isoforms and receptors in the murine epididymis
por: Voisin, Allison, et al.
Publicado: (2020)

HOX genes promote cell proliferation and are potential therapeutic targets in adrenocortical tumours
por: Francis, Jeffrey C., et al.
Publicado: (2020)

Analysis of the Role of Igf2 in Adrenal Tumour Development in Transgenic Mouse Models
por: Drelon, Coralie, et al.
Publicado: (2012)

Nuclear Integrity but Not Topology of Mouse Sperm Chromosome is Affected by Oxidative DNA Damage
por: Champroux, Alexandre, et al.
Publicado: (2018)

Aldo-Keto Reductases 1B in Adrenal Cortex Physiology
por: Pastel, Emilie, et al.
Publicado: (2016)

Aldo-Keto Reductases 1B in Endocrinology and Metabolism
por: Pastel, Emilie, et al.
Publicado: (2012)

Development of a large-scale isolation chamber system for the safe and humane care of medium-sized laboratory animals harboring infectious diseases
por: Pan, Xin, et al.
Publicado: (2010)

Distributions of HLA-A and -B alleles and haplotypes in the Yi ethnic minority of Yunnan, China: relationship to other populations
por: Zhu, Bo-feng, et al.
Publicado: (2010)

Sporadic Creutzfeldt–Jakob disease subtype-specific alterations of the brain proteome: Impact on Rab3a recycling
por: Gawinecka, Joanna, et al.
Publicado: (2012)

Surface modifications of influenza proteins upon virus inactivation by β-propiolactone*
por: She, Yi-Min, et al.
Publicado: (2013)

Applications of mass spectrometry for quantitative protein analysis in formalin-fixed paraffin-embedded tissues
por: Steiner, Carine, et al.
Publicado: (2014)

MALDI Mass Spectrometry Imaging: A Novel Tool for the Identification and Classification of Amyloidosis
por: Winter, Martin, et al.
Publicado: (2017)

Binodal, wireless epidermal electronic systems with in-sensor analytics for neonatal intensive care
por: Chung, Ha Uk, et al.
Publicado: (2019)

Proteomics insights into DNA damage response and translating this knowledge to clinical strategies
por: von Stechow, Louise, et al.
Publicado: (2016)

Proteomic characterization of microdissected breast tissue environment provides a protein‐level overview of malignant transformation
por: Braakman, René B. H., et al.
Publicado: (2017)

Sexual dimorphism in bacterial infections
por: Vázquez-Martínez, Edgar Ricardo, et al.
Publicado: (2018)

Identification of a Crosstalk among TGR5, GLIS2, and TP53 Signaling Pathways in the Control of Undifferentiated Germ Cell Homeostasis and Chemoresistance
por: Thirouard, Laura, et al.
Publicado: (2022)

Differential proinflammatory activities of Spike proteins of SARS-CoV-2 variants of concern
por: Tyrkalska, Sylwia D., et al.
Publicado: (2022)

Atypical Presentation of Testicular Adrenal Rest Tumor (TART) Leading to Bilateral Partial Orchiectomy in a 31-Year-Old Adult Revealing Primary Adrenal Insufficiency with CYP11A1 Deficiency
por: Garcia, Cyril, et al.
Publicado: (2021)

Human cadaver brain infusion skull model for neurosurgical training
por: Olabe, Jon, et al.
Publicado: (2011)

Reversion SAMD9 Mutations Modifying Phenotypic Expression of MIRAGE Syndrome and Allowing Inheritance in a Usually de novo Disorder
por: Roucher-Boulez, Florence, et al.
Publicado: (2019)

Effects of Long-Term Endogenous Corticosteroid Exposure on Brain Volume and Glial Cells in the AdKO Mouse
por: Amaya, Jorge Miguel, et al.
Publicado: (2021)

The 40S-LARP1 complex reprograms the cellular translatome upon mTOR inhibition to preserve the protein synthetic capacity
por: Fuentes, Pedro, et al.
Publicado: (2021)

Testicular impairment in Primary Adrenal Insufficiency caused by Nicotinamide Nucleotide Transhydrogenase (NNT) deficiency - a case report: implication of oxidative stress and importance of fertility preservation
por: Ferreux, Lucile, et al.
Publicado: (2023)

Colibactin-Producing Escherichia coli Induce the Formation of Invasive Carcinomas in a Chronic Inflammation-Associated Mouse Model
por: Salesse, Laurène, et al.
Publicado: (2021)

Gene expression changes in the brain of a Cushing's syndrome mouse model
por: Amaya, Jorge Miguel, et al.
Publicado: (2022)

Indoleamine 2,3-Dioxygenase 1 (Ido1) Is Involved in the Control of Mouse Caput Epididymis Immune Environment
por: Jrad-Lamine, Aicha, et al.
Publicado: (2013)

Isolated hypoaldosteronism as first sign of X-linked adrenal hypoplasia congenita caused by a novel mutation in NR0B1/DAX-1 gene: a case report
por: Iughetti, Lorenzo, et al.
Publicado: (2019)

Three-dimensional imaging of vascular development in the mouse epididymis
por: Damon-Soubeyrand, Christelle, et al.
Publicado: (2023)

Beyond autophagy: LC3-associated phagocytosis and endocytosis
por: Peña-Martinez, Carolina, et al.
Publicado: (2022)

Depressed Levels of Prostaglandin F(2α) in Mice Lacking Akr1b7 Increase Basal Adiposity and Predispose to Diet-Induced Obesity
por: Volat, Fanny E., et al.
Publicado: (2012)

Tetralogy of Fallot Associated With Invasive Adrenocortical Tumor in an Adult Woman
por: Martinez-Quintana, Efren, et al.
Publicado: (2012)

Age- and Sex-Specific TSH Upper-Limit Reference Intervals in the General French Population: There Is a Need to Adjust Our Actual Practices
por: Raverot, Véronique, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_bvgbaba1od88a7bvdbi98j82f1