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Photocatalytic Activity of TiO(2) for the Degradation of Anticancer Drugs

To prevent water pollution, photocatalysis is often used to remove small molecules such as drugs by generating reactive species. This study aimed to determine the photocatalytic activity of two anticancer drugs, imatinib and crizotinib, and to investigate various influences that may alter the kineti...

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Autores principales: Tolić Čop, Kristina, Mutavdžić Pavlović, Dragana, Gazivoda Kraljević, Tatjana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9565840/
https://www.ncbi.nlm.nih.gov/pubmed/36234661
http://dx.doi.org/10.3390/nano12193532
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author Tolić Čop, Kristina
Mutavdžić Pavlović, Dragana
Gazivoda Kraljević, Tatjana
author_facet Tolić Čop, Kristina
Mutavdžić Pavlović, Dragana
Gazivoda Kraljević, Tatjana
author_sort Tolić Čop, Kristina
collection PubMed
description To prevent water pollution, photocatalysis is often used to remove small molecules such as drugs by generating reactive species. This study aimed to determine the photocatalytic activity of two anticancer drugs, imatinib and crizotinib, and to investigate various influences that may alter the kinetic degradation rate and ultimately the efficacy of the process. In order to obtain optimal parameters for the removal of drugs with immobilized TiO(2), the mutual influence of the initial concentration of the contaminant at environmentally relevant pH values was investigated using the response surface modeling approach. The faster kinetic rate of photocatalysis was obtained at pH 5 and at the smallest applied concentration of both drugs. The photocatalytic efficiency was mostly decreased by adding various inorganic salts and organic compounds to the drug mixture. Regarding the degradation mechanism of imatinib and crizotinib, hydroxyl radicals and singlet oxygen showed a major role in photochemical reactions. The formation of seven degradation products for imatinib and fifteen for crizotinib during the optimal photocatalytic process was monitored by high-resolution mass spectrometry (HPLC-QqTOF). Since the newly formed products may pose a hazard to the environment, their toxicity was studied using Vibrio fischeri, where the significant luminescence inhibition was assessed for the mixture of crizotinib degradants during the photocatalysis from 90 to 120 min.
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spelling pubmed-95658402022-10-15 Photocatalytic Activity of TiO(2) for the Degradation of Anticancer Drugs Tolić Čop, Kristina Mutavdžić Pavlović, Dragana Gazivoda Kraljević, Tatjana Nanomaterials (Basel) Article To prevent water pollution, photocatalysis is often used to remove small molecules such as drugs by generating reactive species. This study aimed to determine the photocatalytic activity of two anticancer drugs, imatinib and crizotinib, and to investigate various influences that may alter the kinetic degradation rate and ultimately the efficacy of the process. In order to obtain optimal parameters for the removal of drugs with immobilized TiO(2), the mutual influence of the initial concentration of the contaminant at environmentally relevant pH values was investigated using the response surface modeling approach. The faster kinetic rate of photocatalysis was obtained at pH 5 and at the smallest applied concentration of both drugs. The photocatalytic efficiency was mostly decreased by adding various inorganic salts and organic compounds to the drug mixture. Regarding the degradation mechanism of imatinib and crizotinib, hydroxyl radicals and singlet oxygen showed a major role in photochemical reactions. The formation of seven degradation products for imatinib and fifteen for crizotinib during the optimal photocatalytic process was monitored by high-resolution mass spectrometry (HPLC-QqTOF). Since the newly formed products may pose a hazard to the environment, their toxicity was studied using Vibrio fischeri, where the significant luminescence inhibition was assessed for the mixture of crizotinib degradants during the photocatalysis from 90 to 120 min. MDPI 2022-10-09 /pmc/articles/PMC9565840/ /pubmed/36234661 http://dx.doi.org/10.3390/nano12193532 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Tolić Čop, Kristina
Mutavdžić Pavlović, Dragana
Gazivoda Kraljević, Tatjana
Photocatalytic Activity of TiO(2) for the Degradation of Anticancer Drugs
title Photocatalytic Activity of TiO(2) for the Degradation of Anticancer Drugs
title_full Photocatalytic Activity of TiO(2) for the Degradation of Anticancer Drugs
title_fullStr Photocatalytic Activity of TiO(2) for the Degradation of Anticancer Drugs
title_full_unstemmed Photocatalytic Activity of TiO(2) for the Degradation of Anticancer Drugs
title_short Photocatalytic Activity of TiO(2) for the Degradation of Anticancer Drugs
title_sort photocatalytic activity of tio(2) for the degradation of anticancer drugs
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9565840/
https://www.ncbi.nlm.nih.gov/pubmed/36234661
http://dx.doi.org/10.3390/nano12193532
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