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Dyskinesias in childhood, differential diagnosis and treatment. About a case

INTRODUCTION: Dyskinesias are motor disorders that occur as a side effect to treatment with typical and less frequently with atypical antipsychotic drugs. They are more frequents in child population. Treatment usually consists of decrease the dose of drug or replace it with a better profile tolerabi...

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Autores principales: Valverde Barea, M., Mata Castro, C., Vargas Melero, P., España Osuna, A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cambridge University Press 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9566170/
http://dx.doi.org/10.1192/j.eurpsy.2022.1116
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author Valverde Barea, M.
Mata Castro, C.
Vargas Melero, P.
España Osuna, A.
author_facet Valverde Barea, M.
Mata Castro, C.
Vargas Melero, P.
España Osuna, A.
author_sort Valverde Barea, M.
collection PubMed
description INTRODUCTION: Dyskinesias are motor disorders that occur as a side effect to treatment with typical and less frequently with atypical antipsychotic drugs. They are more frequents in child population. Treatment usually consists of decrease the dose of drug or replace it with a better profile tolerability antipsychotic. Clozapine is an antipsychotic drug indicated as second-generation treatment of motor disorders that appear as side effects to treatment with neuroleptics. OBJECTIVES: Demonstrate the efficacy and tolerability of clozapine in the treatment of dyskinesias in childhood. METHODS: The patient 12 year-old boy, has episodes of psychomotor agitation once a month. This will alternate with quiet moments in which dyskinetic movements are observed in upper limbs, without being able to detect any type triggering environmental factor. Personal history: hydrocele, diagnosed at 8 years becomes neurodevelopmental disorder considered. Neurosurgery tracking for Subarachnoid cyst. Psychopathological examination: Child presents psychomotor restlessness, disruptive behavior, impairments in communication, movement disorder, stereotypies and dyskinetic movements in shoulder and neck. RESULTS: In the patient suffering from an autistic disorder, stereotypies and other motor symptoms were observed, the predominant and most relevant being dyskinetic movements in the shoulder and neck, which appeared one month after starting treatment with risperidone and worsening psychomotor skills. Treatment of dyskinesia with clozapine improved the motor symptoms presented by the patient. CONCLUSIONS: Clozapine should be the treatment of choice in the event of dyskinesias as a secondary effect to other antipsychotic treatments, proving effective in controlling them as well as well tolerated in both adults and children. DISCLOSURE: No significant relationships.
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spelling pubmed-95661702022-10-17 Dyskinesias in childhood, differential diagnosis and treatment. About a case Valverde Barea, M. Mata Castro, C. Vargas Melero, P. España Osuna, A. Eur Psychiatry Abstract INTRODUCTION: Dyskinesias are motor disorders that occur as a side effect to treatment with typical and less frequently with atypical antipsychotic drugs. They are more frequents in child population. Treatment usually consists of decrease the dose of drug or replace it with a better profile tolerability antipsychotic. Clozapine is an antipsychotic drug indicated as second-generation treatment of motor disorders that appear as side effects to treatment with neuroleptics. OBJECTIVES: Demonstrate the efficacy and tolerability of clozapine in the treatment of dyskinesias in childhood. METHODS: The patient 12 year-old boy, has episodes of psychomotor agitation once a month. This will alternate with quiet moments in which dyskinetic movements are observed in upper limbs, without being able to detect any type triggering environmental factor. Personal history: hydrocele, diagnosed at 8 years becomes neurodevelopmental disorder considered. Neurosurgery tracking for Subarachnoid cyst. Psychopathological examination: Child presents psychomotor restlessness, disruptive behavior, impairments in communication, movement disorder, stereotypies and dyskinetic movements in shoulder and neck. RESULTS: In the patient suffering from an autistic disorder, stereotypies and other motor symptoms were observed, the predominant and most relevant being dyskinetic movements in the shoulder and neck, which appeared one month after starting treatment with risperidone and worsening psychomotor skills. Treatment of dyskinesia with clozapine improved the motor symptoms presented by the patient. CONCLUSIONS: Clozapine should be the treatment of choice in the event of dyskinesias as a secondary effect to other antipsychotic treatments, proving effective in controlling them as well as well tolerated in both adults and children. DISCLOSURE: No significant relationships. Cambridge University Press 2022-09-01 /pmc/articles/PMC9566170/ http://dx.doi.org/10.1192/j.eurpsy.2022.1116 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Abstract
Valverde Barea, M.
Mata Castro, C.
Vargas Melero, P.
España Osuna, A.
Dyskinesias in childhood, differential diagnosis and treatment. About a case
title Dyskinesias in childhood, differential diagnosis and treatment. About a case
title_full Dyskinesias in childhood, differential diagnosis and treatment. About a case
title_fullStr Dyskinesias in childhood, differential diagnosis and treatment. About a case
title_full_unstemmed Dyskinesias in childhood, differential diagnosis and treatment. About a case
title_short Dyskinesias in childhood, differential diagnosis and treatment. About a case
title_sort dyskinesias in childhood, differential diagnosis and treatment. about a case
topic Abstract
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9566170/
http://dx.doi.org/10.1192/j.eurpsy.2022.1116
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