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Association between Childhood Exposure to Family Violence and Telomere Length: A Meta-Analysis

The aims of this meta-analysis were to examine the association between childhood exposure to family violence and telomere length and the moderating variables that influence this association. Relevant works published on or before 1st September 2022 were identified through a search in five major datab...

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Autores principales: Chen, Xiao Yan, Lo, Camilla K. M., Chan, Ko Ling, Leung, Wing Cheong, Ip, Patrick
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9566190/
https://www.ncbi.nlm.nih.gov/pubmed/36231453
http://dx.doi.org/10.3390/ijerph191912151
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author Chen, Xiao Yan
Lo, Camilla K. M.
Chan, Ko Ling
Leung, Wing Cheong
Ip, Patrick
author_facet Chen, Xiao Yan
Lo, Camilla K. M.
Chan, Ko Ling
Leung, Wing Cheong
Ip, Patrick
author_sort Chen, Xiao Yan
collection PubMed
description The aims of this meta-analysis were to examine the association between childhood exposure to family violence and telomere length and the moderating variables that influence this association. Relevant works published on or before 1st September 2022 were identified through a search in five major databases in English and 19 articles (N = 18,977) finally met the inclusion criteria. A meta-analysis was conducted to compute the pooled effect size (correlation; r), and moderator analyses were performed using a random effects meta-analytic model. The studies yielded a significant inverse association between childhood exposure to family violence and telomere length, with a small effect size (r = −0.038, 95% CI [−0.070, −0.005], p = 0.025). Furthermore, the strength of this association was stronger in studies examining the co-occurrence of multiple types of violence than in those examining just one type (Q = 8.143, p = 0.004). These findings suggested that victims’ telomere length may be negatively influenced by childhood exposure to family violence and that such impairment appears to be stronger for those who are exposed to multiple types of violence. Future studies are necessary to examine the moderating and mediating factors underlying the association between childhood exposure to family violence and telomere length.
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spelling pubmed-95661902022-10-15 Association between Childhood Exposure to Family Violence and Telomere Length: A Meta-Analysis Chen, Xiao Yan Lo, Camilla K. M. Chan, Ko Ling Leung, Wing Cheong Ip, Patrick Int J Environ Res Public Health Review The aims of this meta-analysis were to examine the association between childhood exposure to family violence and telomere length and the moderating variables that influence this association. Relevant works published on or before 1st September 2022 were identified through a search in five major databases in English and 19 articles (N = 18,977) finally met the inclusion criteria. A meta-analysis was conducted to compute the pooled effect size (correlation; r), and moderator analyses were performed using a random effects meta-analytic model. The studies yielded a significant inverse association between childhood exposure to family violence and telomere length, with a small effect size (r = −0.038, 95% CI [−0.070, −0.005], p = 0.025). Furthermore, the strength of this association was stronger in studies examining the co-occurrence of multiple types of violence than in those examining just one type (Q = 8.143, p = 0.004). These findings suggested that victims’ telomere length may be negatively influenced by childhood exposure to family violence and that such impairment appears to be stronger for those who are exposed to multiple types of violence. Future studies are necessary to examine the moderating and mediating factors underlying the association between childhood exposure to family violence and telomere length. MDPI 2022-09-26 /pmc/articles/PMC9566190/ /pubmed/36231453 http://dx.doi.org/10.3390/ijerph191912151 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Chen, Xiao Yan
Lo, Camilla K. M.
Chan, Ko Ling
Leung, Wing Cheong
Ip, Patrick
Association between Childhood Exposure to Family Violence and Telomere Length: A Meta-Analysis
title Association between Childhood Exposure to Family Violence and Telomere Length: A Meta-Analysis
title_full Association between Childhood Exposure to Family Violence and Telomere Length: A Meta-Analysis
title_fullStr Association between Childhood Exposure to Family Violence and Telomere Length: A Meta-Analysis
title_full_unstemmed Association between Childhood Exposure to Family Violence and Telomere Length: A Meta-Analysis
title_short Association between Childhood Exposure to Family Violence and Telomere Length: A Meta-Analysis
title_sort association between childhood exposure to family violence and telomere length: a meta-analysis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9566190/
https://www.ncbi.nlm.nih.gov/pubmed/36231453
http://dx.doi.org/10.3390/ijerph191912151
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