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Association between the Use of Folic Acid Supplements during Pregnancy and Children’s Cognitive Function at 7–9 Years of Age in the INMA Cohort Study

This study investigated the association between maternal low (<400 μg/day) or high (≥1000 μg/day) folic acid supplements (FAs) use during pregnancy and the attentional function and working memory in boys and girls at age 7–9. A longitudinal analysis based on 1609 mother–child pairs from the Spani...

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Autores principales: Compañ-Gabucio, Laura María, Torres-Collado, Laura, Garcia-de la Hera, Manuela, Fernández-Somoano, Ana, Tardón, Adonina, Julvez, Jordi, Sunyer, Jordi, Rebagliato, Marisa, Murcia, Mario, Ibarluzea, Jesús, Santa-Marina, Loreto, Vioque, Jesús
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9566194/
https://www.ncbi.nlm.nih.gov/pubmed/36231425
http://dx.doi.org/10.3390/ijerph191912123
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author Compañ-Gabucio, Laura María
Torres-Collado, Laura
Garcia-de la Hera, Manuela
Fernández-Somoano, Ana
Tardón, Adonina
Julvez, Jordi
Sunyer, Jordi
Rebagliato, Marisa
Murcia, Mario
Ibarluzea, Jesús
Santa-Marina, Loreto
Vioque, Jesús
author_facet Compañ-Gabucio, Laura María
Torres-Collado, Laura
Garcia-de la Hera, Manuela
Fernández-Somoano, Ana
Tardón, Adonina
Julvez, Jordi
Sunyer, Jordi
Rebagliato, Marisa
Murcia, Mario
Ibarluzea, Jesús
Santa-Marina, Loreto
Vioque, Jesús
author_sort Compañ-Gabucio, Laura María
collection PubMed
description This study investigated the association between maternal low (<400 μg/day) or high (≥1000 μg/day) folic acid supplements (FAs) use during pregnancy and the attentional function and working memory in boys and girls at age 7–9. A longitudinal analysis based on 1609 mother–child pairs from the Spanish Infancia y Medio Ambiente Project was carried out. Multivariable regression analyses revealed that, compared to the recommended FAs use, a low FAs use during the second period of pregnancy was associated with a lower alertness in all children (β = 18.70 ms; 95% CI: 7.51; 29.89) and in girls (β = 30.01 ms; 95% CI: 12.96; 47.01), and with a lower N-back Task performance in boys (d’ number 2-back (β = −0.25; 95% CI: −0.49; 0.01)). A high FAs use throughout the two periods of pregnancy was associated with a better N-back Task performance only in girls (d’ number 2-back (β = 0.28; 95% CI: 0.01; 0.56) and d’ number 3-back (β = 0.32; 95% CI: 0.08; 0.56)). The maternal use of FAs beyond the periconceptional period may affect children’s attentional function and working memory at age 7–9 differently for boys and girls.
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spelling pubmed-95661942022-10-15 Association between the Use of Folic Acid Supplements during Pregnancy and Children’s Cognitive Function at 7–9 Years of Age in the INMA Cohort Study Compañ-Gabucio, Laura María Torres-Collado, Laura Garcia-de la Hera, Manuela Fernández-Somoano, Ana Tardón, Adonina Julvez, Jordi Sunyer, Jordi Rebagliato, Marisa Murcia, Mario Ibarluzea, Jesús Santa-Marina, Loreto Vioque, Jesús Int J Environ Res Public Health Article This study investigated the association between maternal low (<400 μg/day) or high (≥1000 μg/day) folic acid supplements (FAs) use during pregnancy and the attentional function and working memory in boys and girls at age 7–9. A longitudinal analysis based on 1609 mother–child pairs from the Spanish Infancia y Medio Ambiente Project was carried out. Multivariable regression analyses revealed that, compared to the recommended FAs use, a low FAs use during the second period of pregnancy was associated with a lower alertness in all children (β = 18.70 ms; 95% CI: 7.51; 29.89) and in girls (β = 30.01 ms; 95% CI: 12.96; 47.01), and with a lower N-back Task performance in boys (d’ number 2-back (β = −0.25; 95% CI: −0.49; 0.01)). A high FAs use throughout the two periods of pregnancy was associated with a better N-back Task performance only in girls (d’ number 2-back (β = 0.28; 95% CI: 0.01; 0.56) and d’ number 3-back (β = 0.32; 95% CI: 0.08; 0.56)). The maternal use of FAs beyond the periconceptional period may affect children’s attentional function and working memory at age 7–9 differently for boys and girls. MDPI 2022-09-25 /pmc/articles/PMC9566194/ /pubmed/36231425 http://dx.doi.org/10.3390/ijerph191912123 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Compañ-Gabucio, Laura María
Torres-Collado, Laura
Garcia-de la Hera, Manuela
Fernández-Somoano, Ana
Tardón, Adonina
Julvez, Jordi
Sunyer, Jordi
Rebagliato, Marisa
Murcia, Mario
Ibarluzea, Jesús
Santa-Marina, Loreto
Vioque, Jesús
Association between the Use of Folic Acid Supplements during Pregnancy and Children’s Cognitive Function at 7–9 Years of Age in the INMA Cohort Study
title Association between the Use of Folic Acid Supplements during Pregnancy and Children’s Cognitive Function at 7–9 Years of Age in the INMA Cohort Study
title_full Association between the Use of Folic Acid Supplements during Pregnancy and Children’s Cognitive Function at 7–9 Years of Age in the INMA Cohort Study
title_fullStr Association between the Use of Folic Acid Supplements during Pregnancy and Children’s Cognitive Function at 7–9 Years of Age in the INMA Cohort Study
title_full_unstemmed Association between the Use of Folic Acid Supplements during Pregnancy and Children’s Cognitive Function at 7–9 Years of Age in the INMA Cohort Study
title_short Association between the Use of Folic Acid Supplements during Pregnancy and Children’s Cognitive Function at 7–9 Years of Age in the INMA Cohort Study
title_sort association between the use of folic acid supplements during pregnancy and children’s cognitive function at 7–9 years of age in the inma cohort study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9566194/
https://www.ncbi.nlm.nih.gov/pubmed/36231425
http://dx.doi.org/10.3390/ijerph191912123
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