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Association between the Use of Folic Acid Supplements during Pregnancy and Children’s Cognitive Function at 7–9 Years of Age in the INMA Cohort Study
This study investigated the association between maternal low (<400 μg/day) or high (≥1000 μg/day) folic acid supplements (FAs) use during pregnancy and the attentional function and working memory in boys and girls at age 7–9. A longitudinal analysis based on 1609 mother–child pairs from the Spani...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9566194/ https://www.ncbi.nlm.nih.gov/pubmed/36231425 http://dx.doi.org/10.3390/ijerph191912123 |
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author | Compañ-Gabucio, Laura María Torres-Collado, Laura Garcia-de la Hera, Manuela Fernández-Somoano, Ana Tardón, Adonina Julvez, Jordi Sunyer, Jordi Rebagliato, Marisa Murcia, Mario Ibarluzea, Jesús Santa-Marina, Loreto Vioque, Jesús |
author_facet | Compañ-Gabucio, Laura María Torres-Collado, Laura Garcia-de la Hera, Manuela Fernández-Somoano, Ana Tardón, Adonina Julvez, Jordi Sunyer, Jordi Rebagliato, Marisa Murcia, Mario Ibarluzea, Jesús Santa-Marina, Loreto Vioque, Jesús |
author_sort | Compañ-Gabucio, Laura María |
collection | PubMed |
description | This study investigated the association between maternal low (<400 μg/day) or high (≥1000 μg/day) folic acid supplements (FAs) use during pregnancy and the attentional function and working memory in boys and girls at age 7–9. A longitudinal analysis based on 1609 mother–child pairs from the Spanish Infancia y Medio Ambiente Project was carried out. Multivariable regression analyses revealed that, compared to the recommended FAs use, a low FAs use during the second period of pregnancy was associated with a lower alertness in all children (β = 18.70 ms; 95% CI: 7.51; 29.89) and in girls (β = 30.01 ms; 95% CI: 12.96; 47.01), and with a lower N-back Task performance in boys (d’ number 2-back (β = −0.25; 95% CI: −0.49; 0.01)). A high FAs use throughout the two periods of pregnancy was associated with a better N-back Task performance only in girls (d’ number 2-back (β = 0.28; 95% CI: 0.01; 0.56) and d’ number 3-back (β = 0.32; 95% CI: 0.08; 0.56)). The maternal use of FAs beyond the periconceptional period may affect children’s attentional function and working memory at age 7–9 differently for boys and girls. |
format | Online Article Text |
id | pubmed-9566194 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-95661942022-10-15 Association between the Use of Folic Acid Supplements during Pregnancy and Children’s Cognitive Function at 7–9 Years of Age in the INMA Cohort Study Compañ-Gabucio, Laura María Torres-Collado, Laura Garcia-de la Hera, Manuela Fernández-Somoano, Ana Tardón, Adonina Julvez, Jordi Sunyer, Jordi Rebagliato, Marisa Murcia, Mario Ibarluzea, Jesús Santa-Marina, Loreto Vioque, Jesús Int J Environ Res Public Health Article This study investigated the association between maternal low (<400 μg/day) or high (≥1000 μg/day) folic acid supplements (FAs) use during pregnancy and the attentional function and working memory in boys and girls at age 7–9. A longitudinal analysis based on 1609 mother–child pairs from the Spanish Infancia y Medio Ambiente Project was carried out. Multivariable regression analyses revealed that, compared to the recommended FAs use, a low FAs use during the second period of pregnancy was associated with a lower alertness in all children (β = 18.70 ms; 95% CI: 7.51; 29.89) and in girls (β = 30.01 ms; 95% CI: 12.96; 47.01), and with a lower N-back Task performance in boys (d’ number 2-back (β = −0.25; 95% CI: −0.49; 0.01)). A high FAs use throughout the two periods of pregnancy was associated with a better N-back Task performance only in girls (d’ number 2-back (β = 0.28; 95% CI: 0.01; 0.56) and d’ number 3-back (β = 0.32; 95% CI: 0.08; 0.56)). The maternal use of FAs beyond the periconceptional period may affect children’s attentional function and working memory at age 7–9 differently for boys and girls. MDPI 2022-09-25 /pmc/articles/PMC9566194/ /pubmed/36231425 http://dx.doi.org/10.3390/ijerph191912123 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Compañ-Gabucio, Laura María Torres-Collado, Laura Garcia-de la Hera, Manuela Fernández-Somoano, Ana Tardón, Adonina Julvez, Jordi Sunyer, Jordi Rebagliato, Marisa Murcia, Mario Ibarluzea, Jesús Santa-Marina, Loreto Vioque, Jesús Association between the Use of Folic Acid Supplements during Pregnancy and Children’s Cognitive Function at 7–9 Years of Age in the INMA Cohort Study |
title | Association between the Use of Folic Acid Supplements during Pregnancy and Children’s Cognitive Function at 7–9 Years of Age in the INMA Cohort Study |
title_full | Association between the Use of Folic Acid Supplements during Pregnancy and Children’s Cognitive Function at 7–9 Years of Age in the INMA Cohort Study |
title_fullStr | Association between the Use of Folic Acid Supplements during Pregnancy and Children’s Cognitive Function at 7–9 Years of Age in the INMA Cohort Study |
title_full_unstemmed | Association between the Use of Folic Acid Supplements during Pregnancy and Children’s Cognitive Function at 7–9 Years of Age in the INMA Cohort Study |
title_short | Association between the Use of Folic Acid Supplements during Pregnancy and Children’s Cognitive Function at 7–9 Years of Age in the INMA Cohort Study |
title_sort | association between the use of folic acid supplements during pregnancy and children’s cognitive function at 7–9 years of age in the inma cohort study |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9566194/ https://www.ncbi.nlm.nih.gov/pubmed/36231425 http://dx.doi.org/10.3390/ijerph191912123 |
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