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Curative Potential of Substances with Bioactive Properties to Alleviate Cd Toxicity: A Review

Rapid urbanization and industrialization have led to alarming cadmium (Cd) pollution. Cd is a toxic heavy metal without any known physiological function in the organism, leading to severe health threat to the population. Cd has a long half-life (10–30 years) and thus it represents serious concern as...

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Autores principales: Požgajová, Miroslava, Navrátilová, Alica, Kovár, Marek
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9566368/
https://www.ncbi.nlm.nih.gov/pubmed/36231680
http://dx.doi.org/10.3390/ijerph191912380
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author Požgajová, Miroslava
Navrátilová, Alica
Kovár, Marek
author_facet Požgajová, Miroslava
Navrátilová, Alica
Kovár, Marek
author_sort Požgajová, Miroslava
collection PubMed
description Rapid urbanization and industrialization have led to alarming cadmium (Cd) pollution. Cd is a toxic heavy metal without any known physiological function in the organism, leading to severe health threat to the population. Cd has a long half-life (10–30 years) and thus it represents serious concern as it to a great extent accumulates in organs or organelles where it often causes irreversible damage. Moreover, Cd contamination might further lead to certain carcinogenic and non-carcinogenic health risks. Therefore, its negative effect on population health has to be minimalized. As Cd is able to enter the body through the air, water, soil, and food chain one possible way to defend and eliminate Cd toxicities is via dietary supplements that aim to eliminate the adverse effects of Cd to the organism. Naturally occurring bioactive compounds in food or medicinal plants with beneficial, mostly antioxidant, anti-inflammatory, anti-aging, or anti-tumorigenesis impact on the organism, have been described to mitigate the negative effect of various contaminants and pollutants, including Cd. This study summarizes the curative effect of recently studied bioactive substances and mineral elements capable to alleviate the negative impact of Cd on various model systems, supposing that not only the Cd-derived health threat can be reduced, but also prevention and control of Cd toxicity and elimination of Cd contamination can be achieved in the future.
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spelling pubmed-95663682022-10-15 Curative Potential of Substances with Bioactive Properties to Alleviate Cd Toxicity: A Review Požgajová, Miroslava Navrátilová, Alica Kovár, Marek Int J Environ Res Public Health Review Rapid urbanization and industrialization have led to alarming cadmium (Cd) pollution. Cd is a toxic heavy metal without any known physiological function in the organism, leading to severe health threat to the population. Cd has a long half-life (10–30 years) and thus it represents serious concern as it to a great extent accumulates in organs or organelles where it often causes irreversible damage. Moreover, Cd contamination might further lead to certain carcinogenic and non-carcinogenic health risks. Therefore, its negative effect on population health has to be minimalized. As Cd is able to enter the body through the air, water, soil, and food chain one possible way to defend and eliminate Cd toxicities is via dietary supplements that aim to eliminate the adverse effects of Cd to the organism. Naturally occurring bioactive compounds in food or medicinal plants with beneficial, mostly antioxidant, anti-inflammatory, anti-aging, or anti-tumorigenesis impact on the organism, have been described to mitigate the negative effect of various contaminants and pollutants, including Cd. This study summarizes the curative effect of recently studied bioactive substances and mineral elements capable to alleviate the negative impact of Cd on various model systems, supposing that not only the Cd-derived health threat can be reduced, but also prevention and control of Cd toxicity and elimination of Cd contamination can be achieved in the future. MDPI 2022-09-28 /pmc/articles/PMC9566368/ /pubmed/36231680 http://dx.doi.org/10.3390/ijerph191912380 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Požgajová, Miroslava
Navrátilová, Alica
Kovár, Marek
Curative Potential of Substances with Bioactive Properties to Alleviate Cd Toxicity: A Review
title Curative Potential of Substances with Bioactive Properties to Alleviate Cd Toxicity: A Review
title_full Curative Potential of Substances with Bioactive Properties to Alleviate Cd Toxicity: A Review
title_fullStr Curative Potential of Substances with Bioactive Properties to Alleviate Cd Toxicity: A Review
title_full_unstemmed Curative Potential of Substances with Bioactive Properties to Alleviate Cd Toxicity: A Review
title_short Curative Potential of Substances with Bioactive Properties to Alleviate Cd Toxicity: A Review
title_sort curative potential of substances with bioactive properties to alleviate cd toxicity: a review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9566368/
https://www.ncbi.nlm.nih.gov/pubmed/36231680
http://dx.doi.org/10.3390/ijerph191912380
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