IL-1β–dependent extravasation of preexisting lung-restricted autoantibodies during lung transplantation activates complement and mediates primary graft dysfunction

Preexisting lung-restricted autoantibodies (LRAs) are associated with a higher incidence of primary graft dysfunction (PGD), although it remains unclear whether LRAs can drive its pathogenesis. In syngeneic murine left lung transplant recipients, preexisting LRAs worsened graft dysfunction, which wa...

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Detalles Bibliográficos
Autores principales: Yang, Wenbin, Cerier, Emily Jeong, Núñez-Santana, Félix L., Wu, Qiang, Yan, Yuanqing, Kurihara, Chitaru, Liu, Xianpeng, Yeldandi, Anjana, Khurram, Nigar, Avella-Patino, Diego, Sun, Haiying, Budinger, G.R. Scott, Kreisel, Daniel, Mohanakumar, Thalachallour, Lecuona, Emilia, Bharat, Ankit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9566897/
https://www.ncbi.nlm.nih.gov/pubmed/36250462
http://dx.doi.org/10.1172/JCI157975

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