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Impaired renal reserve contributes to preeclampsia via the kynurenine and soluble fms–like tyrosine kinase 1 pathway

To understand how kidney donation leads to an increased risk of preeclampsia, we studied pregnant outbred mice with prior uninephrectomy and compared them with sham-operated littermates carrying both kidneys. During pregnancy, uninephrectomized (UNx) mice failed to achieve a physiological increase i...

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Detalles Bibliográficos
Autores principales:	Dupont, Vincent, Berg, Anders H., Yamashita, Michifumi, Huang, Chengqun, Covarrubias, Ambart E., Ali, Shafat, Stotland, Aleksandr, Van Eyk, Jennifer E., Jim, Belinda, Thadhani, Ravi, Karumanchi, S. Ananth
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Clinical Investigation 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9566901/ https://www.ncbi.nlm.nih.gov/pubmed/35943814 http://dx.doi.org/10.1172/JCI158346

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