Impaired TIGIT expression on B cells drives circulating follicular helper T cell expansion in multiple sclerosis

B cell depletion in patients with relapsing-remitting multiple sclerosis (RRMS) markedly prevents new MRI-detected lesions and disease activity, suggesting the hypothesis that altered B cell function leads to the activation of T cells driving disease pathogenesis. Here, we performed comprehensive an...

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Detalles Bibliográficos
Autores principales: Asashima, Hiromitsu, Axisa, Pierre-Paul, Pham, Thi Hong Giang, Longbrake, Erin E., Ruff, William E., Lele, Nikhil, Cohen, Inessa, Raddassi, Khadir, Sumida, Tomokazu S., Hafler, David A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9566906/
https://www.ncbi.nlm.nih.gov/pubmed/36250467
http://dx.doi.org/10.1172/JCI156254

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9566906/
https://www.ncbi.nlm.nih.gov/pubmed/36250467
http://dx.doi.org/10.1172/JCI156254

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