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The Role of Base Excision Repair in Major Depressive Disorder and Bipolar Disorder
INTRODUCTION: In vivo and in vitro studies suggest that inflammation and oxidative damage may contribute to the pathogenesis of major depressive disorder (MDD) and bipolar disorder (BD). Imbalance between DNA damage and repair is an emerging research area examining pathophysiological mechanisms of t...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cambridge University Press
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9566922/ http://dx.doi.org/10.1192/j.eurpsy.2022.1016 |
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author | Kucuker, M. Ozerdem, A. Ceylan, D. Cabello-Arreola, A. Ho, M.C. Joseph, B. Webb, L. Croarkin, P. Frye, M. Veldic, M. |
author_facet | Kucuker, M. Ozerdem, A. Ceylan, D. Cabello-Arreola, A. Ho, M.C. Joseph, B. Webb, L. Croarkin, P. Frye, M. Veldic, M. |
author_sort | Kucuker, M. |
collection | PubMed |
description | INTRODUCTION: In vivo and in vitro studies suggest that inflammation and oxidative damage may contribute to the pathogenesis of major depressive disorder (MDD) and bipolar disorder (BD). Imbalance between DNA damage and repair is an emerging research area examining pathophysiological mechanisms of these major mood disorders. OBJECTIVES: This systematic review sought to examine current evidence on the association between mood disorders and deficits in base excision repair (BER), the primary repair mechanism for repair of oxidation-induced DNA lesions. METHODS: We conducted a comprehensive literature search of Ovid MEDLINE® Epub Ahead of Print, Ovid MEDLINE® In-Process & Other Non-Indexed Citations, Ovid MEDLINE® Daily, EMBASE (1947), and PsycINFO for studies investigating the alterations in base excision repair in patients with MDD or BD. RESULTS: A total of 1,364 records were identified. 1,352 records remained after duplicates were removed. 24 records were selected for full-text screening and a remaining 12 articles were included in the qualitative synthesis. SNPs (Single Nucleotide Polymorphisms) of several BER genes have been shown to be associated with MDD and BD. However, it was difficult to draw conclusions from BER gene expression studies due to conflicting findings and the small number of studies. CONCLUSIONS: Future studies comparing DNA repair during the manic or depressive episode to remission will give us a better insight regarding the role of DNA repair in mood disorders. These alterations might be utilized as diagnostic and prognostic biomarkers as well as measuring treatment response. DISCLOSURE: No significant relationships. |
format | Online Article Text |
id | pubmed-9566922 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Cambridge University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-95669222022-10-17 The Role of Base Excision Repair in Major Depressive Disorder and Bipolar Disorder Kucuker, M. Ozerdem, A. Ceylan, D. Cabello-Arreola, A. Ho, M.C. Joseph, B. Webb, L. Croarkin, P. Frye, M. Veldic, M. Eur Psychiatry Abstract INTRODUCTION: In vivo and in vitro studies suggest that inflammation and oxidative damage may contribute to the pathogenesis of major depressive disorder (MDD) and bipolar disorder (BD). Imbalance between DNA damage and repair is an emerging research area examining pathophysiological mechanisms of these major mood disorders. OBJECTIVES: This systematic review sought to examine current evidence on the association between mood disorders and deficits in base excision repair (BER), the primary repair mechanism for repair of oxidation-induced DNA lesions. METHODS: We conducted a comprehensive literature search of Ovid MEDLINE® Epub Ahead of Print, Ovid MEDLINE® In-Process & Other Non-Indexed Citations, Ovid MEDLINE® Daily, EMBASE (1947), and PsycINFO for studies investigating the alterations in base excision repair in patients with MDD or BD. RESULTS: A total of 1,364 records were identified. 1,352 records remained after duplicates were removed. 24 records were selected for full-text screening and a remaining 12 articles were included in the qualitative synthesis. SNPs (Single Nucleotide Polymorphisms) of several BER genes have been shown to be associated with MDD and BD. However, it was difficult to draw conclusions from BER gene expression studies due to conflicting findings and the small number of studies. CONCLUSIONS: Future studies comparing DNA repair during the manic or depressive episode to remission will give us a better insight regarding the role of DNA repair in mood disorders. These alterations might be utilized as diagnostic and prognostic biomarkers as well as measuring treatment response. DISCLOSURE: No significant relationships. Cambridge University Press 2022-09-01 /pmc/articles/PMC9566922/ http://dx.doi.org/10.1192/j.eurpsy.2022.1016 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Abstract Kucuker, M. Ozerdem, A. Ceylan, D. Cabello-Arreola, A. Ho, M.C. Joseph, B. Webb, L. Croarkin, P. Frye, M. Veldic, M. The Role of Base Excision Repair in Major Depressive Disorder and Bipolar Disorder |
title | The Role of Base Excision Repair in Major Depressive Disorder and Bipolar Disorder |
title_full | The Role of Base Excision Repair in Major Depressive Disorder and Bipolar Disorder |
title_fullStr | The Role of Base Excision Repair in Major Depressive Disorder and Bipolar Disorder |
title_full_unstemmed | The Role of Base Excision Repair in Major Depressive Disorder and Bipolar Disorder |
title_short | The Role of Base Excision Repair in Major Depressive Disorder and Bipolar Disorder |
title_sort | role of base excision repair in major depressive disorder and bipolar disorder |
topic | Abstract |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9566922/ http://dx.doi.org/10.1192/j.eurpsy.2022.1016 |
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