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The effect of antidepressant treatment on white matter integrity in Major Depression

INTRODUCTION: White matter abnormalities have been identified in major depressive disorder (MDD). Although several diffusion tensor imaging studies found decreased fractional anisotropy (FA) in MDD, the effect of antidepressants (AD) treatment on white matter integrity has been insufficiently studie...

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Autores principales: Tourjman, S., Potvin, S., Milan, R., Kouassi, E., Luck, D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cambridge University Press 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9567142/
http://dx.doi.org/10.1192/j.eurpsy.2022.555
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author Tourjman, S.
Potvin, S.
Milan, R.
Kouassi, E.
Luck, D.
author_facet Tourjman, S.
Potvin, S.
Milan, R.
Kouassi, E.
Luck, D.
author_sort Tourjman, S.
collection PubMed
description INTRODUCTION: White matter abnormalities have been identified in major depressive disorder (MDD). Although several diffusion tensor imaging studies found decreased fractional anisotropy (FA) in MDD, the effect of antidepressants (AD) treatment on white matter integrity has been insufficiently studied. OBJECTIVES: We sought to examine the effect of AD treatment of MDD on white matter, using DTI, in responders compared to nonresponders. METHODS: We included 25 individuals with MDD (HAMD >/=20) without inflammatory, unstable medical/neurological conditions or prolonged duration (> 1 year),or AD or anti-inflammatory treatment >/=1 week preceding first evaluation. Evaluation before treatment and at 16 weeks included depression rating scales, a cognitive battery, inflammatory markers and MRI. Desvenlafaxine was initiated at 50mg with a possible increase to 100mg at 8 weeks. RESULTS: Changes included: increased volume in responders in the right Inferior Fronto-Occipital fasciculus (p=0.0315) and Superior Longitudinal Fasciculus part 3 (p=0.0050); in remitters in the right Inferior Fronto-Occipital fasciculus (p=0.0359) and Superior Longitudinal Fasciculus part 2 (p<0.05) and 3 (p=0.0481); decreased volume in responders in the left Superior Longitudinal Fasciculus part 1 (p=0.0147) and left Corona Radiata(p<0.05); and in remitters in the left Superior Longitudinal Fasciculus part 1 (p=0.0109) and the Corpus Callosum part 5 (p<0.05); decreased FA in the right Cortico Spinal Tract in remitters (p=0.0175) and responders (p=0.0272), and an increase in FA in the left Uncinate Fasciculus in nonremitters (p=0.0493). These results lose significance following Bonferroni correction. CONCLUSIONS: Overall, AD treatment of MDD was not associated with significant changes in FA, whole brain, or specific tract volume in this study. DISCLOSURE: This research was funded by Pfizer Canada.
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spelling pubmed-95671422022-10-17 The effect of antidepressant treatment on white matter integrity in Major Depression Tourjman, S. Potvin, S. Milan, R. Kouassi, E. Luck, D. Eur Psychiatry Abstract INTRODUCTION: White matter abnormalities have been identified in major depressive disorder (MDD). Although several diffusion tensor imaging studies found decreased fractional anisotropy (FA) in MDD, the effect of antidepressants (AD) treatment on white matter integrity has been insufficiently studied. OBJECTIVES: We sought to examine the effect of AD treatment of MDD on white matter, using DTI, in responders compared to nonresponders. METHODS: We included 25 individuals with MDD (HAMD >/=20) without inflammatory, unstable medical/neurological conditions or prolonged duration (> 1 year),or AD or anti-inflammatory treatment >/=1 week preceding first evaluation. Evaluation before treatment and at 16 weeks included depression rating scales, a cognitive battery, inflammatory markers and MRI. Desvenlafaxine was initiated at 50mg with a possible increase to 100mg at 8 weeks. RESULTS: Changes included: increased volume in responders in the right Inferior Fronto-Occipital fasciculus (p=0.0315) and Superior Longitudinal Fasciculus part 3 (p=0.0050); in remitters in the right Inferior Fronto-Occipital fasciculus (p=0.0359) and Superior Longitudinal Fasciculus part 2 (p<0.05) and 3 (p=0.0481); decreased volume in responders in the left Superior Longitudinal Fasciculus part 1 (p=0.0147) and left Corona Radiata(p<0.05); and in remitters in the left Superior Longitudinal Fasciculus part 1 (p=0.0109) and the Corpus Callosum part 5 (p<0.05); decreased FA in the right Cortico Spinal Tract in remitters (p=0.0175) and responders (p=0.0272), and an increase in FA in the left Uncinate Fasciculus in nonremitters (p=0.0493). These results lose significance following Bonferroni correction. CONCLUSIONS: Overall, AD treatment of MDD was not associated with significant changes in FA, whole brain, or specific tract volume in this study. DISCLOSURE: This research was funded by Pfizer Canada. Cambridge University Press 2022-09-01 /pmc/articles/PMC9567142/ http://dx.doi.org/10.1192/j.eurpsy.2022.555 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Abstract
Tourjman, S.
Potvin, S.
Milan, R.
Kouassi, E.
Luck, D.
The effect of antidepressant treatment on white matter integrity in Major Depression
title The effect of antidepressant treatment on white matter integrity in Major Depression
title_full The effect of antidepressant treatment on white matter integrity in Major Depression
title_fullStr The effect of antidepressant treatment on white matter integrity in Major Depression
title_full_unstemmed The effect of antidepressant treatment on white matter integrity in Major Depression
title_short The effect of antidepressant treatment on white matter integrity in Major Depression
title_sort effect of antidepressant treatment on white matter integrity in major depression
topic Abstract
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9567142/
http://dx.doi.org/10.1192/j.eurpsy.2022.555
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