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Children and adolescents exposed to maltreatment already exhibit epigenetic patterns suggestive of heightened low-grade inflammation

INTRODUCTION: Childhood maltreatment (CM) is one of the best described environmental risk factors for developing any psychiatric disorder, while it also confers increased odds for obesity, cardiometabolic disorders and all-cause mortality. Inflammation has been suggested to mediate the widespread cl...

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Autores principales: Palma-Gudiel, H., Marques Feixa, L., Romero, S., Rapado-Castro, M., Blasco-Fontecilla, H., Zorrilla, I., Martín, M., Castro Quintas, Á., Monteserin-Garcia, J.L., Font, E., Ramirez, M., Moreno, D., Marín-Vila, M., Moreno, N., Binder, E., Fañanas, L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cambridge University Press 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9567149/
http://dx.doi.org/10.1192/j.eurpsy.2022.223
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author Palma-Gudiel, H.
Marques Feixa, L.
Romero, S.
Rapado-Castro, M.
Blasco-Fontecilla, H.
Zorrilla, I.
Martín, M.
Castro Quintas, Á.
Monteserin-Garcia, J.L.
Font, E.
Ramirez, M.
Moreno, D.
Marín-Vila, M.
Moreno, N.
Binder, E.
Fañanas, L.
author_facet Palma-Gudiel, H.
Marques Feixa, L.
Romero, S.
Rapado-Castro, M.
Blasco-Fontecilla, H.
Zorrilla, I.
Martín, M.
Castro Quintas, Á.
Monteserin-Garcia, J.L.
Font, E.
Ramirez, M.
Moreno, D.
Marín-Vila, M.
Moreno, N.
Binder, E.
Fañanas, L.
author_sort Palma-Gudiel, H.
collection PubMed
description INTRODUCTION: Childhood maltreatment (CM) is one of the best described environmental risk factors for developing any psychiatric disorder, while it also confers increased odds for obesity, cardiometabolic disorders and all-cause mortality. Inflammation has been suggested to mediate the widespread clinical effects of CM. Previously, Ligthart et al. (2016) identified a polyepigenetic signature of circulating CRP levels, a measure of chronic low-grade inflammation, that has been reliably associated with a wide array of complex disorders. The study of this biomarker could dilucidate the mechanistic relationship between CM and psychiatric outcomes. OBJECTIVES: Thus, CRP-associated epigenetic modifications were explored regarding proximal exposure to CM. METHODS: Genomic DNA was extracted from peripheral blood mononuclear cells of 157 children and adolescents (7 to 17 years old). Exposure to CM was assessed following the TASSCV criteria. Genome-wide DNA methylation was assessed by means of the EPIC array. Fifty-two out of the 58 original CRP-associated CpG sites surpassed quality control and were included in the analysis. Age, sex, psychopathological status and cell type proportions were included as covariates. RESULTS: DNA methylation at 12 out of 52 CpG sites (23%) was significantly associated with exposure to CM (p < .05); 8 of these associations survived correction for multiple testing (q < .05). CONCLUSIONS: This is the first study to date to explore the relationship between childhood maltreatment and an epigenetic signature of chronic low-grade inflammation. Our findings underscore the presence of immune dysregulation early after exposure to CM; further studies are needed to assess the long-term clinical implications of this signature in psychiatric patients. DISCLOSURE: No significant relationships.
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spelling pubmed-95671492022-10-17 Children and adolescents exposed to maltreatment already exhibit epigenetic patterns suggestive of heightened low-grade inflammation Palma-Gudiel, H. Marques Feixa, L. Romero, S. Rapado-Castro, M. Blasco-Fontecilla, H. Zorrilla, I. Martín, M. Castro Quintas, Á. Monteserin-Garcia, J.L. Font, E. Ramirez, M. Moreno, D. Marín-Vila, M. Moreno, N. Binder, E. Fañanas, L. Eur Psychiatry Abstract INTRODUCTION: Childhood maltreatment (CM) is one of the best described environmental risk factors for developing any psychiatric disorder, while it also confers increased odds for obesity, cardiometabolic disorders and all-cause mortality. Inflammation has been suggested to mediate the widespread clinical effects of CM. Previously, Ligthart et al. (2016) identified a polyepigenetic signature of circulating CRP levels, a measure of chronic low-grade inflammation, that has been reliably associated with a wide array of complex disorders. The study of this biomarker could dilucidate the mechanistic relationship between CM and psychiatric outcomes. OBJECTIVES: Thus, CRP-associated epigenetic modifications were explored regarding proximal exposure to CM. METHODS: Genomic DNA was extracted from peripheral blood mononuclear cells of 157 children and adolescents (7 to 17 years old). Exposure to CM was assessed following the TASSCV criteria. Genome-wide DNA methylation was assessed by means of the EPIC array. Fifty-two out of the 58 original CRP-associated CpG sites surpassed quality control and were included in the analysis. Age, sex, psychopathological status and cell type proportions were included as covariates. RESULTS: DNA methylation at 12 out of 52 CpG sites (23%) was significantly associated with exposure to CM (p < .05); 8 of these associations survived correction for multiple testing (q < .05). CONCLUSIONS: This is the first study to date to explore the relationship between childhood maltreatment and an epigenetic signature of chronic low-grade inflammation. Our findings underscore the presence of immune dysregulation early after exposure to CM; further studies are needed to assess the long-term clinical implications of this signature in psychiatric patients. DISCLOSURE: No significant relationships. Cambridge University Press 2022-09-01 /pmc/articles/PMC9567149/ http://dx.doi.org/10.1192/j.eurpsy.2022.223 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Abstract
Palma-Gudiel, H.
Marques Feixa, L.
Romero, S.
Rapado-Castro, M.
Blasco-Fontecilla, H.
Zorrilla, I.
Martín, M.
Castro Quintas, Á.
Monteserin-Garcia, J.L.
Font, E.
Ramirez, M.
Moreno, D.
Marín-Vila, M.
Moreno, N.
Binder, E.
Fañanas, L.
Children and adolescents exposed to maltreatment already exhibit epigenetic patterns suggestive of heightened low-grade inflammation
title Children and adolescents exposed to maltreatment already exhibit epigenetic patterns suggestive of heightened low-grade inflammation
title_full Children and adolescents exposed to maltreatment already exhibit epigenetic patterns suggestive of heightened low-grade inflammation
title_fullStr Children and adolescents exposed to maltreatment already exhibit epigenetic patterns suggestive of heightened low-grade inflammation
title_full_unstemmed Children and adolescents exposed to maltreatment already exhibit epigenetic patterns suggestive of heightened low-grade inflammation
title_short Children and adolescents exposed to maltreatment already exhibit epigenetic patterns suggestive of heightened low-grade inflammation
title_sort children and adolescents exposed to maltreatment already exhibit epigenetic patterns suggestive of heightened low-grade inflammation
topic Abstract
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9567149/
http://dx.doi.org/10.1192/j.eurpsy.2022.223
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