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Children and adolescents exposed to maltreatment already exhibit epigenetic patterns suggestive of heightened low-grade inflammation
INTRODUCTION: Childhood maltreatment (CM) is one of the best described environmental risk factors for developing any psychiatric disorder, while it also confers increased odds for obesity, cardiometabolic disorders and all-cause mortality. Inflammation has been suggested to mediate the widespread cl...
Autores principales: | , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cambridge University Press
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9567149/ http://dx.doi.org/10.1192/j.eurpsy.2022.223 |
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author | Palma-Gudiel, H. Marques Feixa, L. Romero, S. Rapado-Castro, M. Blasco-Fontecilla, H. Zorrilla, I. Martín, M. Castro Quintas, Á. Monteserin-Garcia, J.L. Font, E. Ramirez, M. Moreno, D. Marín-Vila, M. Moreno, N. Binder, E. Fañanas, L. |
author_facet | Palma-Gudiel, H. Marques Feixa, L. Romero, S. Rapado-Castro, M. Blasco-Fontecilla, H. Zorrilla, I. Martín, M. Castro Quintas, Á. Monteserin-Garcia, J.L. Font, E. Ramirez, M. Moreno, D. Marín-Vila, M. Moreno, N. Binder, E. Fañanas, L. |
author_sort | Palma-Gudiel, H. |
collection | PubMed |
description | INTRODUCTION: Childhood maltreatment (CM) is one of the best described environmental risk factors for developing any psychiatric disorder, while it also confers increased odds for obesity, cardiometabolic disorders and all-cause mortality. Inflammation has been suggested to mediate the widespread clinical effects of CM. Previously, Ligthart et al. (2016) identified a polyepigenetic signature of circulating CRP levels, a measure of chronic low-grade inflammation, that has been reliably associated with a wide array of complex disorders. The study of this biomarker could dilucidate the mechanistic relationship between CM and psychiatric outcomes. OBJECTIVES: Thus, CRP-associated epigenetic modifications were explored regarding proximal exposure to CM. METHODS: Genomic DNA was extracted from peripheral blood mononuclear cells of 157 children and adolescents (7 to 17 years old). Exposure to CM was assessed following the TASSCV criteria. Genome-wide DNA methylation was assessed by means of the EPIC array. Fifty-two out of the 58 original CRP-associated CpG sites surpassed quality control and were included in the analysis. Age, sex, psychopathological status and cell type proportions were included as covariates. RESULTS: DNA methylation at 12 out of 52 CpG sites (23%) was significantly associated with exposure to CM (p < .05); 8 of these associations survived correction for multiple testing (q < .05). CONCLUSIONS: This is the first study to date to explore the relationship between childhood maltreatment and an epigenetic signature of chronic low-grade inflammation. Our findings underscore the presence of immune dysregulation early after exposure to CM; further studies are needed to assess the long-term clinical implications of this signature in psychiatric patients. DISCLOSURE: No significant relationships. |
format | Online Article Text |
id | pubmed-9567149 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Cambridge University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-95671492022-10-17 Children and adolescents exposed to maltreatment already exhibit epigenetic patterns suggestive of heightened low-grade inflammation Palma-Gudiel, H. Marques Feixa, L. Romero, S. Rapado-Castro, M. Blasco-Fontecilla, H. Zorrilla, I. Martín, M. Castro Quintas, Á. Monteserin-Garcia, J.L. Font, E. Ramirez, M. Moreno, D. Marín-Vila, M. Moreno, N. Binder, E. Fañanas, L. Eur Psychiatry Abstract INTRODUCTION: Childhood maltreatment (CM) is one of the best described environmental risk factors for developing any psychiatric disorder, while it also confers increased odds for obesity, cardiometabolic disorders and all-cause mortality. Inflammation has been suggested to mediate the widespread clinical effects of CM. Previously, Ligthart et al. (2016) identified a polyepigenetic signature of circulating CRP levels, a measure of chronic low-grade inflammation, that has been reliably associated with a wide array of complex disorders. The study of this biomarker could dilucidate the mechanistic relationship between CM and psychiatric outcomes. OBJECTIVES: Thus, CRP-associated epigenetic modifications were explored regarding proximal exposure to CM. METHODS: Genomic DNA was extracted from peripheral blood mononuclear cells of 157 children and adolescents (7 to 17 years old). Exposure to CM was assessed following the TASSCV criteria. Genome-wide DNA methylation was assessed by means of the EPIC array. Fifty-two out of the 58 original CRP-associated CpG sites surpassed quality control and were included in the analysis. Age, sex, psychopathological status and cell type proportions were included as covariates. RESULTS: DNA methylation at 12 out of 52 CpG sites (23%) was significantly associated with exposure to CM (p < .05); 8 of these associations survived correction for multiple testing (q < .05). CONCLUSIONS: This is the first study to date to explore the relationship between childhood maltreatment and an epigenetic signature of chronic low-grade inflammation. Our findings underscore the presence of immune dysregulation early after exposure to CM; further studies are needed to assess the long-term clinical implications of this signature in psychiatric patients. DISCLOSURE: No significant relationships. Cambridge University Press 2022-09-01 /pmc/articles/PMC9567149/ http://dx.doi.org/10.1192/j.eurpsy.2022.223 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Abstract Palma-Gudiel, H. Marques Feixa, L. Romero, S. Rapado-Castro, M. Blasco-Fontecilla, H. Zorrilla, I. Martín, M. Castro Quintas, Á. Monteserin-Garcia, J.L. Font, E. Ramirez, M. Moreno, D. Marín-Vila, M. Moreno, N. Binder, E. Fañanas, L. Children and adolescents exposed to maltreatment already exhibit epigenetic patterns suggestive of heightened low-grade inflammation |
title | Children and adolescents exposed to maltreatment already exhibit epigenetic patterns suggestive of heightened low-grade inflammation |
title_full | Children and adolescents exposed to maltreatment already exhibit epigenetic patterns suggestive of heightened low-grade inflammation |
title_fullStr | Children and adolescents exposed to maltreatment already exhibit epigenetic patterns suggestive of heightened low-grade inflammation |
title_full_unstemmed | Children and adolescents exposed to maltreatment already exhibit epigenetic patterns suggestive of heightened low-grade inflammation |
title_short | Children and adolescents exposed to maltreatment already exhibit epigenetic patterns suggestive of heightened low-grade inflammation |
title_sort | children and adolescents exposed to maltreatment already exhibit epigenetic patterns suggestive of heightened low-grade inflammation |
topic | Abstract |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9567149/ http://dx.doi.org/10.1192/j.eurpsy.2022.223 |
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