Cargando…

Increased spectral power of theta rhythm is not associated with decreased supragranular thickness in first-episode schizophrenia

INTRODUCTION: Schizophrenia is associated with disturbances in neurophysiological processes. However, the relation of EEG and ERP parameters to structural supragranular cortical abnormalities, observed in schizophrenia, remains unclear. OBJECTIVES: The purpose was to characterize EEG and ERP disturb...

Descripción completa

Detalles Bibliográficos
Autores principales: Tomyshev, A., Lebedeva, I., Abdullina, E., Kaleda, V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cambridge University Press 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9567202/
http://dx.doi.org/10.1192/j.eurpsy.2022.847
_version_ 1784809342839554048
author Tomyshev, A.
Lebedeva, I.
Abdullina, E.
Kaleda, V.
author_facet Tomyshev, A.
Lebedeva, I.
Abdullina, E.
Kaleda, V.
author_sort Tomyshev, A.
collection PubMed
description INTRODUCTION: Schizophrenia is associated with disturbances in neurophysiological processes. However, the relation of EEG and ERP parameters to structural supragranular cortical abnormalities, observed in schizophrenia, remains unclear. OBJECTIVES: The purpose was to characterize EEG and ERP disturbances and their relationship to changes occurring in supragranular cortical layers in subjects with schizophrenia. METHODS: 43 first-episode schizophrenia (FES) male patients and 43 matched healthy controls (HC) underwent background EEG and standard two-tones oddball ERP recording and structural MRI at 3T Philips scanner. MRI images were processed via FreeSurfer and MATLAB to derive two markers specific to supragranular thickness change: gyral-sulcal thickness differences (GSTD) and gyral-sulcal intrinsic curvature differences on pial surface (GSCD) (github.com/kwagstyl/schizophrenia_gyral_sulcal). RESULTS: Theta rhythm spectral power was increased in FES while P300 amplitudes and latencies, N100 (to non-targets) amplitudes, alpha rhythm spectral power were not altered compared to HC. GSCD measures were increased in temporal, parietal and occipital cortices, whereas both GSTD and GSCD were increased in the right frontal cortex in FES. No correlations between altered EEG and supragranular thickness markers survived correction for multiple comparisons. CONCLUSIONS: Presumably, theta rhythm has a widespread circuit of generators, including the cortical ones. However, we have not found correlations between EEG and supragranular markers in FES. Considering an absence of correlations between theta and hippocampal volumes (Lebedeva et al., 2020), a speculative interpretation is that the neurophysiological disturbances may be associated with a more complex patterns of more localized structural and functional impairments. DISCLOSURE: The work was supported by RFBR grant 20-013-00748.
format Online
Article
Text
id pubmed-9567202
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Cambridge University Press
record_format MEDLINE/PubMed
spelling pubmed-95672022022-10-17 Increased spectral power of theta rhythm is not associated with decreased supragranular thickness in first-episode schizophrenia Tomyshev, A. Lebedeva, I. Abdullina, E. Kaleda, V. Eur Psychiatry Abstract INTRODUCTION: Schizophrenia is associated with disturbances in neurophysiological processes. However, the relation of EEG and ERP parameters to structural supragranular cortical abnormalities, observed in schizophrenia, remains unclear. OBJECTIVES: The purpose was to characterize EEG and ERP disturbances and their relationship to changes occurring in supragranular cortical layers in subjects with schizophrenia. METHODS: 43 first-episode schizophrenia (FES) male patients and 43 matched healthy controls (HC) underwent background EEG and standard two-tones oddball ERP recording and structural MRI at 3T Philips scanner. MRI images were processed via FreeSurfer and MATLAB to derive two markers specific to supragranular thickness change: gyral-sulcal thickness differences (GSTD) and gyral-sulcal intrinsic curvature differences on pial surface (GSCD) (github.com/kwagstyl/schizophrenia_gyral_sulcal). RESULTS: Theta rhythm spectral power was increased in FES while P300 amplitudes and latencies, N100 (to non-targets) amplitudes, alpha rhythm spectral power were not altered compared to HC. GSCD measures were increased in temporal, parietal and occipital cortices, whereas both GSTD and GSCD were increased in the right frontal cortex in FES. No correlations between altered EEG and supragranular thickness markers survived correction for multiple comparisons. CONCLUSIONS: Presumably, theta rhythm has a widespread circuit of generators, including the cortical ones. However, we have not found correlations between EEG and supragranular markers in FES. Considering an absence of correlations between theta and hippocampal volumes (Lebedeva et al., 2020), a speculative interpretation is that the neurophysiological disturbances may be associated with a more complex patterns of more localized structural and functional impairments. DISCLOSURE: The work was supported by RFBR grant 20-013-00748. Cambridge University Press 2022-09-01 /pmc/articles/PMC9567202/ http://dx.doi.org/10.1192/j.eurpsy.2022.847 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Abstract
Tomyshev, A.
Lebedeva, I.
Abdullina, E.
Kaleda, V.
Increased spectral power of theta rhythm is not associated with decreased supragranular thickness in first-episode schizophrenia
title Increased spectral power of theta rhythm is not associated with decreased supragranular thickness in first-episode schizophrenia
title_full Increased spectral power of theta rhythm is not associated with decreased supragranular thickness in first-episode schizophrenia
title_fullStr Increased spectral power of theta rhythm is not associated with decreased supragranular thickness in first-episode schizophrenia
title_full_unstemmed Increased spectral power of theta rhythm is not associated with decreased supragranular thickness in first-episode schizophrenia
title_short Increased spectral power of theta rhythm is not associated with decreased supragranular thickness in first-episode schizophrenia
title_sort increased spectral power of theta rhythm is not associated with decreased supragranular thickness in first-episode schizophrenia
topic Abstract
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9567202/
http://dx.doi.org/10.1192/j.eurpsy.2022.847
work_keys_str_mv AT tomysheva increasedspectralpowerofthetarhythmisnotassociatedwithdecreasedsupragranularthicknessinfirstepisodeschizophrenia
AT lebedevai increasedspectralpowerofthetarhythmisnotassociatedwithdecreasedsupragranularthicknessinfirstepisodeschizophrenia
AT abdullinae increasedspectralpowerofthetarhythmisnotassociatedwithdecreasedsupragranularthicknessinfirstepisodeschizophrenia
AT kaledav increasedspectralpowerofthetarhythmisnotassociatedwithdecreasedsupragranularthicknessinfirstepisodeschizophrenia