Repression and 3D-restructuring resolves regulatory conflicts in evolutionarily rearranged genomes

Regulatory landscapes drive complex developmental gene expression, but it remains unclear how their integrity is maintained when incorporating novel genes and functions during evolution. Here, we investigated how a placental mammal-specific gene, Zfp42, emerged in an ancient vertebrate topologically...

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Detalles Bibliográficos
Autores principales: Ringel, Alessa R., Szabo, Quentin, Chiariello, Andrea M., Chudzik, Konrad, Schöpflin, Robert, Rothe, Patricia, Mattei, Alexandra L., Zehnder, Tobias, Harnett, Dermot, Laupert, Verena, Bianco, Simona, Hetzel, Sara, Glaser, Juliane, Phan, Mai H.Q., Schindler, Magdalena, Ibrahim, Daniel M., Paliou, Christina, Esposito, Andrea, Prada-Medina, Cesar A., Haas, Stefan A., Giere, Peter, Vingron, Martin, Wittler, Lars, Meissner, Alexander, Nicodemi, Mario, Cavalli, Giacomo, Bantignies, Frédéric, Mundlos, Stefan, Robson, Michael I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9567273/
https://www.ncbi.nlm.nih.gov/pubmed/36179666
http://dx.doi.org/10.1016/j.cell.2022.09.006

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