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Evaluation of Brain Functions in Conversion Disorder with PET/MRI

INTRODUCTION: Since there is no objective criteria, unique clinical symptom or laboratory test to make the diagnosis of conversion disorder; its diagnosis and treatment is challenging which leads to a poor prognosis. OBJECTIVES: The aim of this study is to investigate the brain metabolic activity of...

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Autores principales: Tatlı, S.Z., Özkan, E., Araz, M., Erden, M.İ., Şentürk Cankorur, V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cambridge University Press 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9567343/
http://dx.doi.org/10.1192/j.eurpsy.2022.573
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author Tatlı, S.Z.
Özkan, E.
Araz, M.
Erden, M.İ.
Şentürk Cankorur, V.
author_facet Tatlı, S.Z.
Özkan, E.
Araz, M.
Erden, M.İ.
Şentürk Cankorur, V.
author_sort Tatlı, S.Z.
collection PubMed
description INTRODUCTION: Since there is no objective criteria, unique clinical symptom or laboratory test to make the diagnosis of conversion disorder; its diagnosis and treatment is challenging which leads to a poor prognosis. OBJECTIVES: The aim of this study is to investigate the brain metabolic activity of patients with conversion disorder with PET/MRI. METHODS: 12 conversion disorder patients were included. Somatosensory Amplification Scale, Somatoform Dissociation Scale, Patient Health Questionnaire-15, Toronto Alexithymia Scale were filled in by the participants. Neurological, mental status examinations, Wechsler Adult Intelligence Scale-Revised Form (WAIS-R) and brain F18-FDG-PET/MRI were performed. Structured Clinical Interview for DSM-5, Hamilton Depression and Anxiety Scales were administered. RESULTS: 83% of the patients were female, the mean age was 33 years and average education period was 10,2 years. WAIS-R total scores were consistent with low avarage intelligence level.Cerebral hypermetabolism was detected in the primary visual cortex. Average regional brain metabolic activity had a tendency to increase in bilateral prefrontal, right sensorimotor (SM),cingulate,right inferior parietal,occipital lateral,right temporal lateral cortices and cerebellum. Each region was metabolically correlated with the homologous contralateral regions. Significant correlations in the same direction was found between frontal and occipital lateral & primary visual cortices; cerebellum and left sensorimotor cortex; anterior cingulate cortex(ACC) and superior parietal cortex & cerebellum. No correlations were found between ACC and left SM cortex. CONCLUSIONS: Findings of our study indicate that there are moderate changes in regional brain metabolic activities and inter-regional correlations in patients with conversion disorder. In order to confirm these findings, furter functional neuroimaging studies are needed. DISCLOSURE: No significant relationships.
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spelling pubmed-95673432022-10-17 Evaluation of Brain Functions in Conversion Disorder with PET/MRI Tatlı, S.Z. Özkan, E. Araz, M. Erden, M.İ. Şentürk Cankorur, V. Eur Psychiatry Abstract INTRODUCTION: Since there is no objective criteria, unique clinical symptom or laboratory test to make the diagnosis of conversion disorder; its diagnosis and treatment is challenging which leads to a poor prognosis. OBJECTIVES: The aim of this study is to investigate the brain metabolic activity of patients with conversion disorder with PET/MRI. METHODS: 12 conversion disorder patients were included. Somatosensory Amplification Scale, Somatoform Dissociation Scale, Patient Health Questionnaire-15, Toronto Alexithymia Scale were filled in by the participants. Neurological, mental status examinations, Wechsler Adult Intelligence Scale-Revised Form (WAIS-R) and brain F18-FDG-PET/MRI were performed. Structured Clinical Interview for DSM-5, Hamilton Depression and Anxiety Scales were administered. RESULTS: 83% of the patients were female, the mean age was 33 years and average education period was 10,2 years. WAIS-R total scores were consistent with low avarage intelligence level.Cerebral hypermetabolism was detected in the primary visual cortex. Average regional brain metabolic activity had a tendency to increase in bilateral prefrontal, right sensorimotor (SM),cingulate,right inferior parietal,occipital lateral,right temporal lateral cortices and cerebellum. Each region was metabolically correlated with the homologous contralateral regions. Significant correlations in the same direction was found between frontal and occipital lateral & primary visual cortices; cerebellum and left sensorimotor cortex; anterior cingulate cortex(ACC) and superior parietal cortex & cerebellum. No correlations were found between ACC and left SM cortex. CONCLUSIONS: Findings of our study indicate that there are moderate changes in regional brain metabolic activities and inter-regional correlations in patients with conversion disorder. In order to confirm these findings, furter functional neuroimaging studies are needed. DISCLOSURE: No significant relationships. Cambridge University Press 2022-09-01 /pmc/articles/PMC9567343/ http://dx.doi.org/10.1192/j.eurpsy.2022.573 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Abstract
Tatlı, S.Z.
Özkan, E.
Araz, M.
Erden, M.İ.
Şentürk Cankorur, V.
Evaluation of Brain Functions in Conversion Disorder with PET/MRI
title Evaluation of Brain Functions in Conversion Disorder with PET/MRI
title_full Evaluation of Brain Functions in Conversion Disorder with PET/MRI
title_fullStr Evaluation of Brain Functions in Conversion Disorder with PET/MRI
title_full_unstemmed Evaluation of Brain Functions in Conversion Disorder with PET/MRI
title_short Evaluation of Brain Functions in Conversion Disorder with PET/MRI
title_sort evaluation of brain functions in conversion disorder with pet/mri
topic Abstract
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9567343/
http://dx.doi.org/10.1192/j.eurpsy.2022.573
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