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Possible association between high social anxiety level and genetic markers in young adult Internet addicts

INTRODUCTION: Internet addiction (IA) is a rapidly growing disorder especially among adolescents and young adults. Social anxiety is one of the risk factors for IA. Also, genes involved in dopaminergic and serotoninergic systems are among the candidate genes most frequently associated with IA. OBJEC...

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Autores principales: Trusova, A., Gvozdetckii, A., Merkulova, T., Chuprova, N., Solovieva, M., Grechany, S., Soldatkin, V., Yakovlev, A., Ponizovsky, P., Iluyk, R., Egorov, A., Krupitsky, E., Kibitov, A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cambridge University Press 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9567570/
http://dx.doi.org/10.1192/j.eurpsy.2022.2107
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author Trusova, A.
Gvozdetckii, A.
Merkulova, T.
Chuprova, N.
Solovieva, M.
Grechany, S.
Soldatkin, V.
Yakovlev, A.
Ponizovsky, P.
Iluyk, R.
Egorov, A.
Krupitsky, E.
Kibitov, A.
author_facet Trusova, A.
Gvozdetckii, A.
Merkulova, T.
Chuprova, N.
Solovieva, M.
Grechany, S.
Soldatkin, V.
Yakovlev, A.
Ponizovsky, P.
Iluyk, R.
Egorov, A.
Krupitsky, E.
Kibitov, A.
author_sort Trusova, A.
collection PubMed
description INTRODUCTION: Internet addiction (IA) is a rapidly growing disorder especially among adolescents and young adults. Social anxiety is one of the risk factors for IA. Also, genes involved in dopaminergic and serotoninergic systems are among the candidate genes most frequently associated with IA. OBJECTIVES: The study aimed to investigate the association between social anxiety level and genetic markers in young adult Internet addicts. METHODS: IA group included 44 people (Chen/Chinese Internet Addiction Scale (CIAS) score ≥ 65), 75,0% males), the average age 22,0 [18,0;25,0] y.o. (Md [Q1; Q3]). Healthy control group (CIAS score was less 65) included 120 people, (73,3% males), the average age 23,0 [22,0;24,0] y.o. Psychometric measures: Liebowitz Social Anxiety Scale (LSAS). Genetic markers: rs2072450 in GRIN2A, rs2832407 in GRiK-GluR5, HUMTH01 in TH01(S<9, L>=9 repeats). The impact of genotypes on social anxiety scores was identified using Proportional Odd Logit modeling taking into account group affiliation. RESULTS: Group of IA reported significantly higher levels in almost all LSAS measures including total score. We found that carriers of the genotypes rs2072450 CC (p=0.004 vs.CA/AA), rs2832407 CC (p=0.023 vs AA), and TH01 SS (p=0.013 vs. LL) scored significantly higher of LSAS total in the IA group. There were no significant differences in the healthy controls group. CONCLUSIONS: The rs2072450(CC) in GRIN2A, rs2832407(CC) in GRiK-GluR5, and HUMTH01 in TH01(SS) genotypes may be possibly associated with higher social anxiety levels in Internet addicts. DISCLOSURE: The study was supported by the Russian Foundation for Basic Research (RFBR), project #18-29-22079.
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spelling pubmed-95675702022-10-17 Possible association between high social anxiety level and genetic markers in young adult Internet addicts Trusova, A. Gvozdetckii, A. Merkulova, T. Chuprova, N. Solovieva, M. Grechany, S. Soldatkin, V. Yakovlev, A. Ponizovsky, P. Iluyk, R. Egorov, A. Krupitsky, E. Kibitov, A. Eur Psychiatry Abstract INTRODUCTION: Internet addiction (IA) is a rapidly growing disorder especially among adolescents and young adults. Social anxiety is one of the risk factors for IA. Also, genes involved in dopaminergic and serotoninergic systems are among the candidate genes most frequently associated with IA. OBJECTIVES: The study aimed to investigate the association between social anxiety level and genetic markers in young adult Internet addicts. METHODS: IA group included 44 people (Chen/Chinese Internet Addiction Scale (CIAS) score ≥ 65), 75,0% males), the average age 22,0 [18,0;25,0] y.o. (Md [Q1; Q3]). Healthy control group (CIAS score was less 65) included 120 people, (73,3% males), the average age 23,0 [22,0;24,0] y.o. Psychometric measures: Liebowitz Social Anxiety Scale (LSAS). Genetic markers: rs2072450 in GRIN2A, rs2832407 in GRiK-GluR5, HUMTH01 in TH01(S<9, L>=9 repeats). The impact of genotypes on social anxiety scores was identified using Proportional Odd Logit modeling taking into account group affiliation. RESULTS: Group of IA reported significantly higher levels in almost all LSAS measures including total score. We found that carriers of the genotypes rs2072450 CC (p=0.004 vs.CA/AA), rs2832407 CC (p=0.023 vs AA), and TH01 SS (p=0.013 vs. LL) scored significantly higher of LSAS total in the IA group. There were no significant differences in the healthy controls group. CONCLUSIONS: The rs2072450(CC) in GRIN2A, rs2832407(CC) in GRiK-GluR5, and HUMTH01 in TH01(SS) genotypes may be possibly associated with higher social anxiety levels in Internet addicts. DISCLOSURE: The study was supported by the Russian Foundation for Basic Research (RFBR), project #18-29-22079. Cambridge University Press 2022-09-01 /pmc/articles/PMC9567570/ http://dx.doi.org/10.1192/j.eurpsy.2022.2107 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Abstract
Trusova, A.
Gvozdetckii, A.
Merkulova, T.
Chuprova, N.
Solovieva, M.
Grechany, S.
Soldatkin, V.
Yakovlev, A.
Ponizovsky, P.
Iluyk, R.
Egorov, A.
Krupitsky, E.
Kibitov, A.
Possible association between high social anxiety level and genetic markers in young adult Internet addicts
title Possible association between high social anxiety level and genetic markers in young adult Internet addicts
title_full Possible association between high social anxiety level and genetic markers in young adult Internet addicts
title_fullStr Possible association between high social anxiety level and genetic markers in young adult Internet addicts
title_full_unstemmed Possible association between high social anxiety level and genetic markers in young adult Internet addicts
title_short Possible association between high social anxiety level and genetic markers in young adult Internet addicts
title_sort possible association between high social anxiety level and genetic markers in young adult internet addicts
topic Abstract
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9567570/
http://dx.doi.org/10.1192/j.eurpsy.2022.2107
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