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Neonatal onset of bipolar spectrum disorder through a three-generation familial study

INTRODUCTION: Age at onset of pediatric bipolar spectrum disorder (BSD) is an important marker of a more severe form and a highly heritable mood/mental disorder. OBJECTIVES: Here, we report a familial Tunisian BSD follow-up study showing a very early onset of the BSD at the neonatal period. METHODS:...

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Autores principales: Abdelmoula, B., Sellami, S., Keskes, M., Bouayed Abdelmoula, N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cambridge University Press 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9567785/
http://dx.doi.org/10.1192/j.eurpsy.2022.1034
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author Abdelmoula, B.
Sellami, S.
Keskes, M.
Bouayed Abdelmoula, N.
author_facet Abdelmoula, B.
Sellami, S.
Keskes, M.
Bouayed Abdelmoula, N.
author_sort Abdelmoula, B.
collection PubMed
description INTRODUCTION: Age at onset of pediatric bipolar spectrum disorder (BSD) is an important marker of a more severe form and a highly heritable mood/mental disorder. OBJECTIVES: Here, we report a familial Tunisian BSD follow-up study showing a very early onset of the BSD at the neonatal period. METHODS: A 28-year-old female and her 30-year old sister were referred for genetic and psychological assessments due to recurrent depressive episodes. RESULTS: Psychological assessment revealed a BSD type II with episodes of hypomania for both patients. The 30-year old sister presented a mixed form of BSD coupled with autistic traits, hyposomnia and obsessive-compulsive behaviors. Intellectual and cognitive abilities were without concerns. Familial history revealed BDS among paternal relatives including the brothers’ and sisters’ father as well as all their uncles offspring’s, and their grandparents, who were consanguineous. The depressive mood was a common sign in the three generations. Personal history revealed significant signs of a very early onset of the disorder since the neonatal period for the two sisters as well as for their four paternal cousins who also presented BSD features. Familial risk of BSD in this family correlates with a variably higher personal risk of other psychiatric disorders such as anxiety, drug abuse, personality disorders, and autism spectrum disorder. CONCLUSIONS: Environmental conditions, familial care and educational level have a strong correlation with the severity and the efficiency of cognitive management of BSD and its psychiatric comorbidities. BSD is highly heterogeneous and polygenic and personalized management has considerable clinical repercussions benefits. DISCLOSURE: No significant relationships.
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spelling pubmed-95677852022-10-17 Neonatal onset of bipolar spectrum disorder through a three-generation familial study Abdelmoula, B. Sellami, S. Keskes, M. Bouayed Abdelmoula, N. Eur Psychiatry Abstract INTRODUCTION: Age at onset of pediatric bipolar spectrum disorder (BSD) is an important marker of a more severe form and a highly heritable mood/mental disorder. OBJECTIVES: Here, we report a familial Tunisian BSD follow-up study showing a very early onset of the BSD at the neonatal period. METHODS: A 28-year-old female and her 30-year old sister were referred for genetic and psychological assessments due to recurrent depressive episodes. RESULTS: Psychological assessment revealed a BSD type II with episodes of hypomania for both patients. The 30-year old sister presented a mixed form of BSD coupled with autistic traits, hyposomnia and obsessive-compulsive behaviors. Intellectual and cognitive abilities were without concerns. Familial history revealed BDS among paternal relatives including the brothers’ and sisters’ father as well as all their uncles offspring’s, and their grandparents, who were consanguineous. The depressive mood was a common sign in the three generations. Personal history revealed significant signs of a very early onset of the disorder since the neonatal period for the two sisters as well as for their four paternal cousins who also presented BSD features. Familial risk of BSD in this family correlates with a variably higher personal risk of other psychiatric disorders such as anxiety, drug abuse, personality disorders, and autism spectrum disorder. CONCLUSIONS: Environmental conditions, familial care and educational level have a strong correlation with the severity and the efficiency of cognitive management of BSD and its psychiatric comorbidities. BSD is highly heterogeneous and polygenic and personalized management has considerable clinical repercussions benefits. DISCLOSURE: No significant relationships. Cambridge University Press 2022-09-01 /pmc/articles/PMC9567785/ http://dx.doi.org/10.1192/j.eurpsy.2022.1034 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Abstract
Abdelmoula, B.
Sellami, S.
Keskes, M.
Bouayed Abdelmoula, N.
Neonatal onset of bipolar spectrum disorder through a three-generation familial study
title Neonatal onset of bipolar spectrum disorder through a three-generation familial study
title_full Neonatal onset of bipolar spectrum disorder through a three-generation familial study
title_fullStr Neonatal onset of bipolar spectrum disorder through a three-generation familial study
title_full_unstemmed Neonatal onset of bipolar spectrum disorder through a three-generation familial study
title_short Neonatal onset of bipolar spectrum disorder through a three-generation familial study
title_sort neonatal onset of bipolar spectrum disorder through a three-generation familial study
topic Abstract
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9567785/
http://dx.doi.org/10.1192/j.eurpsy.2022.1034
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