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Effects of natural polymorphisms in SARS-CoV-2 RNA-dependent RNA polymerase on its activity and sensitivity to inhibitors in vitro

SARS-CoV-2 RNA-dependent RNA polymerase (RdRp) is the key enzyme required for viral replication and mRNA synthesis. RdRp is one of the most conserved viral proteins and a promising target for antiviral drugs and inhibitors. At the same time, analysis of public databases reveals multiple variants of...

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Detalles Bibliográficos
Autores principales:	Miropolskaya, Nataliya, Kozlov, Maxim, Petushkov, Ivan, Prostova, Maria, Pupov, Danil, Esyunina, Daria, Kochetkov, Sergey, Kulbachinskiy, Andrey
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier B.V. and Société Française de Biochimie et Biologie Moléculaire (SFBBM). 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9568283/ https://www.ncbi.nlm.nih.gov/pubmed/36252889 http://dx.doi.org/10.1016/j.biochi.2022.10.007

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