The High Expression of Adhering and Circulating Integrin Serves as a Diagnostic Marker in Venous Thromboembolism

OBJECTIVE: To investigate the diagnostic value of circulating integrins β1, 2, and 3 in venous thrombosis (VTE). MATERIALS AND METHODS: A total of 474 VTE patients and 306 patients with nonhigh risk for VTE as the control group were studied. Levels of adhering integrins β1, 2, and 3 were detected by...

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Autores principales: Yang, Fan, Song, Yanli, Song, Haoming, Zheng, Weiping, Wang, Lemin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9568339/
https://www.ncbi.nlm.nih.gov/pubmed/36245842
http://dx.doi.org/10.1155/2022/9610071
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author Yang, Fan
Song, Yanli
Song, Haoming
Zheng, Weiping
Wang, Lemin
author_facet Yang, Fan
Song, Yanli
Song, Haoming
Zheng, Weiping
Wang, Lemin
author_sort Yang, Fan
collection PubMed
description OBJECTIVE: To investigate the diagnostic value of circulating integrins β1, 2, and 3 in venous thrombosis (VTE). MATERIALS AND METHODS: A total of 474 VTE patients and 306 patients with nonhigh risk for VTE as the control group were studied. Levels of adhering integrins β1, 2, and 3 were detected by flow cytometry. Levels of circulating integrins β1, 2, and 3 in serum were measured by enzyme-linked immunosorbent assay. RESULTS: We found that integrins β1, 2, and 3 were expressed highly both in serum and on the surface of leukocytes and platelets in venous thromboembolism. The levels of circulating integrins β1, 2, and 3 are positively correlated with adhering integrins. It showed excellent clinical diagnostic performance of circulating integrins β1, 2, and 3 in venous thromboembolism. CONCLUSIONS: Integrin subunit β can be used as a diagnostic marker with high sensitivity and specificity for venous thromboembolism.
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spelling pubmed-95683392022-10-15 The High Expression of Adhering and Circulating Integrin Serves as a Diagnostic Marker in Venous Thromboembolism Yang, Fan Song, Yanli Song, Haoming Zheng, Weiping Wang, Lemin Comput Math Methods Med Research Article OBJECTIVE: To investigate the diagnostic value of circulating integrins β1, 2, and 3 in venous thrombosis (VTE). MATERIALS AND METHODS: A total of 474 VTE patients and 306 patients with nonhigh risk for VTE as the control group were studied. Levels of adhering integrins β1, 2, and 3 were detected by flow cytometry. Levels of circulating integrins β1, 2, and 3 in serum were measured by enzyme-linked immunosorbent assay. RESULTS: We found that integrins β1, 2, and 3 were expressed highly both in serum and on the surface of leukocytes and platelets in venous thromboembolism. The levels of circulating integrins β1, 2, and 3 are positively correlated with adhering integrins. It showed excellent clinical diagnostic performance of circulating integrins β1, 2, and 3 in venous thromboembolism. CONCLUSIONS: Integrin subunit β can be used as a diagnostic marker with high sensitivity and specificity for venous thromboembolism. Hindawi 2022-10-07 /pmc/articles/PMC9568339/ /pubmed/36245842 http://dx.doi.org/10.1155/2022/9610071 Text en Copyright © 2022 Fan Yang et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Yang, Fan
Song, Yanli
Song, Haoming
Zheng, Weiping
Wang, Lemin
The High Expression of Adhering and Circulating Integrin Serves as a Diagnostic Marker in Venous Thromboembolism
title The High Expression of Adhering and Circulating Integrin Serves as a Diagnostic Marker in Venous Thromboembolism
title_full The High Expression of Adhering and Circulating Integrin Serves as a Diagnostic Marker in Venous Thromboembolism
title_fullStr The High Expression of Adhering and Circulating Integrin Serves as a Diagnostic Marker in Venous Thromboembolism
title_full_unstemmed The High Expression of Adhering and Circulating Integrin Serves as a Diagnostic Marker in Venous Thromboembolism
title_short The High Expression of Adhering and Circulating Integrin Serves as a Diagnostic Marker in Venous Thromboembolism
title_sort high expression of adhering and circulating integrin serves as a diagnostic marker in venous thromboembolism
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9568339/
https://www.ncbi.nlm.nih.gov/pubmed/36245842
http://dx.doi.org/10.1155/2022/9610071
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