Cargando…
Peculiarities of Integrating Mechanical Valves in Microfluidic Channels Using Direct Laser Writing
Regenerative medicine is a fast expanding scientific topic. One of the main areas of development directions in this field is the usage of additive manufacturing to fabricate functional components that would be later integrated directly into the human body. One such structure could be a microfluidic...
Autores principales: | , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9568359/ https://www.ncbi.nlm.nih.gov/pubmed/36245929 http://dx.doi.org/10.1155/2022/9411024 |
_version_ | 1784809629142745088 |
---|---|
author | Hernandez-Cedillo, Lucero Andriukaitis, Deividas Šerpytis, Lukas Drevinskas, Tomas Kornyšova, Olga Kaškonienė, Vilma Stankevičius, Mantas Bimbiraitė-Survilienė, Kristina Maruška, Audrius Sigitas Jonušauskas, Linas |
author_facet | Hernandez-Cedillo, Lucero Andriukaitis, Deividas Šerpytis, Lukas Drevinskas, Tomas Kornyšova, Olga Kaškonienė, Vilma Stankevičius, Mantas Bimbiraitė-Survilienė, Kristina Maruška, Audrius Sigitas Jonušauskas, Linas |
author_sort | Hernandez-Cedillo, Lucero |
collection | PubMed |
description | Regenerative medicine is a fast expanding scientific topic. One of the main areas of development directions in this field is the usage of additive manufacturing to fabricate functional components that would be later integrated directly into the human body. One such structure could be a microfluidic valve which could replace its biological counterpart in veins as it is worn out over the lifetime of a patient. In this work, we explore the possibility to produce such a structure by using multiphoton polymerization (MPP). This technology allows the creation of 3D structures on a micro- and nanometric scale. In this work, the fabrication of microfluidic systems by direct laser writing was carried out. These devices consist of a 100 μm diameter channel and within it a 200 μm long three-dimensional one-way mechanical valve. The idea of this device is to have a single flow direction for a fluid. For testing purposes, the valve was integrated into a femtosecond laser-made glass microfluidic system. Such a system acts as a platform for testing such small and delicate devices. Measurements of the dimensions of the device within such a testing platform were taken and the repeatability of this process was analyzed. The capability to use it for flow direction control is measured. Possible implications to the field of regenerative medicine are discussed. |
format | Online Article Text |
id | pubmed-9568359 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-95683592022-10-15 Peculiarities of Integrating Mechanical Valves in Microfluidic Channels Using Direct Laser Writing Hernandez-Cedillo, Lucero Andriukaitis, Deividas Šerpytis, Lukas Drevinskas, Tomas Kornyšova, Olga Kaškonienė, Vilma Stankevičius, Mantas Bimbiraitė-Survilienė, Kristina Maruška, Audrius Sigitas Jonušauskas, Linas Appl Bionics Biomech Research Article Regenerative medicine is a fast expanding scientific topic. One of the main areas of development directions in this field is the usage of additive manufacturing to fabricate functional components that would be later integrated directly into the human body. One such structure could be a microfluidic valve which could replace its biological counterpart in veins as it is worn out over the lifetime of a patient. In this work, we explore the possibility to produce such a structure by using multiphoton polymerization (MPP). This technology allows the creation of 3D structures on a micro- and nanometric scale. In this work, the fabrication of microfluidic systems by direct laser writing was carried out. These devices consist of a 100 μm diameter channel and within it a 200 μm long three-dimensional one-way mechanical valve. The idea of this device is to have a single flow direction for a fluid. For testing purposes, the valve was integrated into a femtosecond laser-made glass microfluidic system. Such a system acts as a platform for testing such small and delicate devices. Measurements of the dimensions of the device within such a testing platform were taken and the repeatability of this process was analyzed. The capability to use it for flow direction control is measured. Possible implications to the field of regenerative medicine are discussed. Hindawi 2022-10-07 /pmc/articles/PMC9568359/ /pubmed/36245929 http://dx.doi.org/10.1155/2022/9411024 Text en Copyright © 2022 Lucero Hernandez-Cedillo et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Hernandez-Cedillo, Lucero Andriukaitis, Deividas Šerpytis, Lukas Drevinskas, Tomas Kornyšova, Olga Kaškonienė, Vilma Stankevičius, Mantas Bimbiraitė-Survilienė, Kristina Maruška, Audrius Sigitas Jonušauskas, Linas Peculiarities of Integrating Mechanical Valves in Microfluidic Channels Using Direct Laser Writing |
title | Peculiarities of Integrating Mechanical Valves in Microfluidic Channels Using Direct Laser Writing |
title_full | Peculiarities of Integrating Mechanical Valves in Microfluidic Channels Using Direct Laser Writing |
title_fullStr | Peculiarities of Integrating Mechanical Valves in Microfluidic Channels Using Direct Laser Writing |
title_full_unstemmed | Peculiarities of Integrating Mechanical Valves in Microfluidic Channels Using Direct Laser Writing |
title_short | Peculiarities of Integrating Mechanical Valves in Microfluidic Channels Using Direct Laser Writing |
title_sort | peculiarities of integrating mechanical valves in microfluidic channels using direct laser writing |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9568359/ https://www.ncbi.nlm.nih.gov/pubmed/36245929 http://dx.doi.org/10.1155/2022/9411024 |
work_keys_str_mv | AT hernandezcedillolucero peculiaritiesofintegratingmechanicalvalvesinmicrofluidicchannelsusingdirectlaserwriting AT andriukaitisdeividas peculiaritiesofintegratingmechanicalvalvesinmicrofluidicchannelsusingdirectlaserwriting AT serpytislukas peculiaritiesofintegratingmechanicalvalvesinmicrofluidicchannelsusingdirectlaserwriting AT drevinskastomas peculiaritiesofintegratingmechanicalvalvesinmicrofluidicchannelsusingdirectlaserwriting AT kornysovaolga peculiaritiesofintegratingmechanicalvalvesinmicrofluidicchannelsusingdirectlaserwriting AT kaskonienevilma peculiaritiesofintegratingmechanicalvalvesinmicrofluidicchannelsusingdirectlaserwriting AT stankeviciusmantas peculiaritiesofintegratingmechanicalvalvesinmicrofluidicchannelsusingdirectlaserwriting AT bimbiraitesurvilienekristina peculiaritiesofintegratingmechanicalvalvesinmicrofluidicchannelsusingdirectlaserwriting AT maruskaaudriussigitas peculiaritiesofintegratingmechanicalvalvesinmicrofluidicchannelsusingdirectlaserwriting AT jonusauskaslinas peculiaritiesofintegratingmechanicalvalvesinmicrofluidicchannelsusingdirectlaserwriting |