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Parallel detection of SARS‐CoV‐2 epitopes reveals dynamic immunodominance profiles of CD8 (+) T memory cells in convalescent COVID‐19 donors

OBJECTIVES: High‐magnitude CD8(+) T cell responses are associated with mild COVID‐19 disease; however, the underlying characteristics that define CD8(+) T cell‐mediated protection are not well understood. The antigenic breadth and the immunodominance hierarchies of epitope‐specific CD8(+) T cells re...

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Detalles Bibliográficos
Autores principales: van den Dijssel, Jet, Hagen, Ruth R, de Jongh, Rivka, Steenhuis, Maurice, Rispens, Theo, Geerdes, Dionne M, Mok, Juk Yee, Kragten, Angela HM, Duurland, Mariël C, Verstegen, Niels JM, van Ham, S Marieke, van Esch, Wim JE, van Gisbergen, Klaas PJM, Hombrink, Pleun, ten Brinke, Anja, van de Sandt, Carolien E
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9568370/
https://www.ncbi.nlm.nih.gov/pubmed/36254196
http://dx.doi.org/10.1002/cti2.1423