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Decitabine enhances targeting of AML cells by NY-ESO-1-specific TCR-T cells and promotes the maintenance of effector function and the memory phenotype

NY-ESO-1 is a well-known cancer-testis antigen (CTA) with re-expression in numerous cancer types, but its expression is suppressed in myeloid leukemia cells. Patients with acute myeloid leukemia (AML) receiving decitabine (DAC) exhibit induced expression of NY-ESO-1 in blasts; thus, we investigated...

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Detalles Bibliográficos
Autores principales:	Kang, Synat, Wang, Lixin, Xu, Lu, Wang, Ruiqi, Kang, Qingzheng, Gao, Xuefeng, Yu, Li
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9568428/ https://www.ncbi.nlm.nih.gov/pubmed/36097193 http://dx.doi.org/10.1038/s41388-022-02455-y

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