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Abdominal myoepithelial carcinoma: A rare abdominal wall entity of an uncommon tumor

INTRODUCTION AND IMPORTANCE: Myoepithelial carcinomas are a diverse group of tumors exhibiting myoepithelial differentiation. There have been increasing reports of extra-salivary sites of origin for myoepithelial carcinomas such as soft tissues, bone and visceral areas. Due to this entity's rar...

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Autores principales: Shoaib, Daania, Khan, Saqib Raza, Rashid, Yasmin Abdul, Zahir, Muhammad Nauman
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9568730/
https://www.ncbi.nlm.nih.gov/pubmed/36099768
http://dx.doi.org/10.1016/j.ijscr.2022.107618
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author Shoaib, Daania
Khan, Saqib Raza
Rashid, Yasmin Abdul
Zahir, Muhammad Nauman
author_facet Shoaib, Daania
Khan, Saqib Raza
Rashid, Yasmin Abdul
Zahir, Muhammad Nauman
author_sort Shoaib, Daania
collection PubMed
description INTRODUCTION AND IMPORTANCE: Myoepithelial carcinomas are a diverse group of tumors exhibiting myoepithelial differentiation. There have been increasing reports of extra-salivary sites of origin for myoepithelial carcinomas such as soft tissues, bone and visceral areas. Due to this entity's rarity, definite diagnostic and treatment parameters are somewhat limited. We present the case of a myoepithelial carcinoma arising from the abdominal wall, a rare site of origin of an uncommon tumor. CASE PRESENTATION: A 37-year-old gentleman presented to our institution in Oct 2018 with a recurrent abdominal mass for which he underwent wide local excision after completing the workup, which included systemic scans and relevant blood investigations. The histopathology report was consistent with malignant abdominal myoepithelial carcinoma. However, subsequent follow-up scans in May 2019 showed disease progression with the appearance of multiple lung metastases. After a detailed discussion, he was started on Pazopanib 800 mg orally once a day, on which he remained stable till May 2022. It was then when he experienced clinical disease progression confirmed on systemic scans, so he was offered palliative systemic chemotherapy. CLINICAL DISCUSSION: Abdominal malignant myoepithelial carcinomas are an infrequent entity. However, this case highlights its critical diagnostic markers and primary and recurrent abdominal myoepithelial carcinoma management. CONCLUSION: Abdominal myoepithelial carcinomas, although rare, are also under-recognized. Thus, keeping an index of high suspicion for these tumors and being armed with knowledge regarding the heterogeneity of its features would lead to better diagnostic awareness and documentation, paving the way for better evidence-based treatments.
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spelling pubmed-95687302022-10-16 Abdominal myoepithelial carcinoma: A rare abdominal wall entity of an uncommon tumor Shoaib, Daania Khan, Saqib Raza Rashid, Yasmin Abdul Zahir, Muhammad Nauman Int J Surg Case Rep Case Report INTRODUCTION AND IMPORTANCE: Myoepithelial carcinomas are a diverse group of tumors exhibiting myoepithelial differentiation. There have been increasing reports of extra-salivary sites of origin for myoepithelial carcinomas such as soft tissues, bone and visceral areas. Due to this entity's rarity, definite diagnostic and treatment parameters are somewhat limited. We present the case of a myoepithelial carcinoma arising from the abdominal wall, a rare site of origin of an uncommon tumor. CASE PRESENTATION: A 37-year-old gentleman presented to our institution in Oct 2018 with a recurrent abdominal mass for which he underwent wide local excision after completing the workup, which included systemic scans and relevant blood investigations. The histopathology report was consistent with malignant abdominal myoepithelial carcinoma. However, subsequent follow-up scans in May 2019 showed disease progression with the appearance of multiple lung metastases. After a detailed discussion, he was started on Pazopanib 800 mg orally once a day, on which he remained stable till May 2022. It was then when he experienced clinical disease progression confirmed on systemic scans, so he was offered palliative systemic chemotherapy. CLINICAL DISCUSSION: Abdominal malignant myoepithelial carcinomas are an infrequent entity. However, this case highlights its critical diagnostic markers and primary and recurrent abdominal myoepithelial carcinoma management. CONCLUSION: Abdominal myoepithelial carcinomas, although rare, are also under-recognized. Thus, keeping an index of high suspicion for these tumors and being armed with knowledge regarding the heterogeneity of its features would lead to better diagnostic awareness and documentation, paving the way for better evidence-based treatments. Elsevier 2022-09-09 /pmc/articles/PMC9568730/ /pubmed/36099768 http://dx.doi.org/10.1016/j.ijscr.2022.107618 Text en © 2022 The Authors https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Case Report
Shoaib, Daania
Khan, Saqib Raza
Rashid, Yasmin Abdul
Zahir, Muhammad Nauman
Abdominal myoepithelial carcinoma: A rare abdominal wall entity of an uncommon tumor
title Abdominal myoepithelial carcinoma: A rare abdominal wall entity of an uncommon tumor
title_full Abdominal myoepithelial carcinoma: A rare abdominal wall entity of an uncommon tumor
title_fullStr Abdominal myoepithelial carcinoma: A rare abdominal wall entity of an uncommon tumor
title_full_unstemmed Abdominal myoepithelial carcinoma: A rare abdominal wall entity of an uncommon tumor
title_short Abdominal myoepithelial carcinoma: A rare abdominal wall entity of an uncommon tumor
title_sort abdominal myoepithelial carcinoma: a rare abdominal wall entity of an uncommon tumor
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9568730/
https://www.ncbi.nlm.nih.gov/pubmed/36099768
http://dx.doi.org/10.1016/j.ijscr.2022.107618
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