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Microarray expression profiling of fndc3a zebrafish mutants

The group of Fibronectin type III domain-containing (FNDC; InterPro IPR003961) protein super family splits into a large number of gene-orthologues and mediates a variety of cellular functions during development and disease. They act as anti-inflammatory factors, are linked to cell-cell-interactions,...

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Autores principales: Liedtke, Daniel, Klopocki, Eva
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Caltech Library 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9568745/
https://www.ncbi.nlm.nih.gov/pubmed/36254247
http://dx.doi.org/10.17912/micropub.biology.000646
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author Liedtke, Daniel
Klopocki, Eva
author_facet Liedtke, Daniel
Klopocki, Eva
author_sort Liedtke, Daniel
collection PubMed
description The group of Fibronectin type III domain-containing (FNDC; InterPro IPR003961) protein super family splits into a large number of gene-orthologues and mediates a variety of cellular functions during development and disease. They act as anti-inflammatory factors, are linked to cell-cell-interactions, regulate cell signaling and are associated with different cancer types, like cervical and colorectal. One member of this gene family is FNDC3A , which influences different developmental processes in vertebrates, like Sertoli cell/spermatid adhesion in mice testis, bone traits in chicken, and fin development in zebrafish. To identify downstream molecular processes during vertebrate development we investigated gene expression profiles in the previously established fndc3a zebrafish mutants via microarray analyses on 22 hpf embryos (26-somite stage). Our analyses imply distinct transcriptional profiles between genotype groups and hint to altered cell binding and catalytic activity in fndc3a mutants.
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spelling pubmed-95687452022-10-16 Microarray expression profiling of fndc3a zebrafish mutants Liedtke, Daniel Klopocki, Eva MicroPubl Biol New Finding The group of Fibronectin type III domain-containing (FNDC; InterPro IPR003961) protein super family splits into a large number of gene-orthologues and mediates a variety of cellular functions during development and disease. They act as anti-inflammatory factors, are linked to cell-cell-interactions, regulate cell signaling and are associated with different cancer types, like cervical and colorectal. One member of this gene family is FNDC3A , which influences different developmental processes in vertebrates, like Sertoli cell/spermatid adhesion in mice testis, bone traits in chicken, and fin development in zebrafish. To identify downstream molecular processes during vertebrate development we investigated gene expression profiles in the previously established fndc3a zebrafish mutants via microarray analyses on 22 hpf embryos (26-somite stage). Our analyses imply distinct transcriptional profiles between genotype groups and hint to altered cell binding and catalytic activity in fndc3a mutants. Caltech Library 2022-09-30 /pmc/articles/PMC9568745/ /pubmed/36254247 http://dx.doi.org/10.17912/micropub.biology.000646 Text en Copyright: © 2022 by the authors https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle New Finding
Liedtke, Daniel
Klopocki, Eva
Microarray expression profiling of fndc3a zebrafish mutants
title Microarray expression profiling of fndc3a zebrafish mutants
title_full Microarray expression profiling of fndc3a zebrafish mutants
title_fullStr Microarray expression profiling of fndc3a zebrafish mutants
title_full_unstemmed Microarray expression profiling of fndc3a zebrafish mutants
title_short Microarray expression profiling of fndc3a zebrafish mutants
title_sort microarray expression profiling of fndc3a zebrafish mutants
topic New Finding
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9568745/
https://www.ncbi.nlm.nih.gov/pubmed/36254247
http://dx.doi.org/10.17912/micropub.biology.000646
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