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Microarray expression profiling of fndc3a zebrafish mutants
The group of Fibronectin type III domain-containing (FNDC; InterPro IPR003961) protein super family splits into a large number of gene-orthologues and mediates a variety of cellular functions during development and disease. They act as anti-inflammatory factors, are linked to cell-cell-interactions,...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Caltech Library
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9568745/ https://www.ncbi.nlm.nih.gov/pubmed/36254247 http://dx.doi.org/10.17912/micropub.biology.000646 |
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author | Liedtke, Daniel Klopocki, Eva |
author_facet | Liedtke, Daniel Klopocki, Eva |
author_sort | Liedtke, Daniel |
collection | PubMed |
description | The group of Fibronectin type III domain-containing (FNDC; InterPro IPR003961) protein super family splits into a large number of gene-orthologues and mediates a variety of cellular functions during development and disease. They act as anti-inflammatory factors, are linked to cell-cell-interactions, regulate cell signaling and are associated with different cancer types, like cervical and colorectal. One member of this gene family is FNDC3A , which influences different developmental processes in vertebrates, like Sertoli cell/spermatid adhesion in mice testis, bone traits in chicken, and fin development in zebrafish. To identify downstream molecular processes during vertebrate development we investigated gene expression profiles in the previously established fndc3a zebrafish mutants via microarray analyses on 22 hpf embryos (26-somite stage). Our analyses imply distinct transcriptional profiles between genotype groups and hint to altered cell binding and catalytic activity in fndc3a mutants. |
format | Online Article Text |
id | pubmed-9568745 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Caltech Library |
record_format | MEDLINE/PubMed |
spelling | pubmed-95687452022-10-16 Microarray expression profiling of fndc3a zebrafish mutants Liedtke, Daniel Klopocki, Eva MicroPubl Biol New Finding The group of Fibronectin type III domain-containing (FNDC; InterPro IPR003961) protein super family splits into a large number of gene-orthologues and mediates a variety of cellular functions during development and disease. They act as anti-inflammatory factors, are linked to cell-cell-interactions, regulate cell signaling and are associated with different cancer types, like cervical and colorectal. One member of this gene family is FNDC3A , which influences different developmental processes in vertebrates, like Sertoli cell/spermatid adhesion in mice testis, bone traits in chicken, and fin development in zebrafish. To identify downstream molecular processes during vertebrate development we investigated gene expression profiles in the previously established fndc3a zebrafish mutants via microarray analyses on 22 hpf embryos (26-somite stage). Our analyses imply distinct transcriptional profiles between genotype groups and hint to altered cell binding and catalytic activity in fndc3a mutants. Caltech Library 2022-09-30 /pmc/articles/PMC9568745/ /pubmed/36254247 http://dx.doi.org/10.17912/micropub.biology.000646 Text en Copyright: © 2022 by the authors https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | New Finding Liedtke, Daniel Klopocki, Eva Microarray expression profiling of fndc3a zebrafish mutants |
title |
Microarray expression profiling of
fndc3a
zebrafish mutants
|
title_full |
Microarray expression profiling of
fndc3a
zebrafish mutants
|
title_fullStr |
Microarray expression profiling of
fndc3a
zebrafish mutants
|
title_full_unstemmed |
Microarray expression profiling of
fndc3a
zebrafish mutants
|
title_short |
Microarray expression profiling of
fndc3a
zebrafish mutants
|
title_sort | microarray expression profiling of
fndc3a
zebrafish mutants |
topic | New Finding |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9568745/ https://www.ncbi.nlm.nih.gov/pubmed/36254247 http://dx.doi.org/10.17912/micropub.biology.000646 |
work_keys_str_mv | AT liedtkedaniel microarrayexpressionprofilingoffndc3azebrafishmutants AT klopockieva microarrayexpressionprofilingoffndc3azebrafishmutants |