Synthesis of Glycyrrhizic Acid Conjugates with Amino-Acid Methyl Esters and their Ability to Stimulate Antibody Genesis in Mice

Conjugates of glycyrrhizic acid (GA) with methyl esters of L-amino acids (valine, methionine, and glutamic acid) containing the amino-acid residues in the carbohydrate moiety of the glycoside were synthesized using 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide. The resulting GA conjugates at a dose...

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Autores principales: Baltina, L. A., Petrova, S. F., Gabdrakhmanova, S. F., Makara, N. S., Sapozhnikova, T. A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9568971/
https://www.ncbi.nlm.nih.gov/pubmed/36268163
http://dx.doi.org/10.1007/s11094-022-02724-w
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author Baltina, L. A.
Baltina, L. A.
Petrova, S. F.
Gabdrakhmanova, S. F.
Makara, N. S.
Sapozhnikova, T. A.
author_facet Baltina, L. A.
Baltina, L. A.
Petrova, S. F.
Gabdrakhmanova, S. F.
Makara, N. S.
Sapozhnikova, T. A.
author_sort Baltina, L. A.
collection PubMed
description Conjugates of glycyrrhizic acid (GA) with methyl esters of L-amino acids (valine, methionine, and glutamic acid) containing the amino-acid residues in the carbohydrate moiety of the glycoside were synthesized using 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide. The resulting GA conjugates at a dose of 2 mg/kg stimulated a primary immune response (production of antibody-forming cells, AFCs) in outbred mice by 1.6 – 3 times as compared with the control. The conjugate of GA with Glu(OMe)(2) stimulated antibody genesis in outbred mice 1.7 times more efficiently than N-acetylmuramyl dipeptide and showed a stimulating effect on AFC production in the spleen of CBA mice.
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spelling pubmed-95689712022-10-16 Synthesis of Glycyrrhizic Acid Conjugates with Amino-Acid Methyl Esters and their Ability to Stimulate Antibody Genesis in Mice Baltina, L. A. Baltina, L. A. Petrova, S. F. Gabdrakhmanova, S. F. Makara, N. S. Sapozhnikova, T. A. Pharm Chem J Article Conjugates of glycyrrhizic acid (GA) with methyl esters of L-amino acids (valine, methionine, and glutamic acid) containing the amino-acid residues in the carbohydrate moiety of the glycoside were synthesized using 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide. The resulting GA conjugates at a dose of 2 mg/kg stimulated a primary immune response (production of antibody-forming cells, AFCs) in outbred mice by 1.6 – 3 times as compared with the control. The conjugate of GA with Glu(OMe)(2) stimulated antibody genesis in outbred mice 1.7 times more efficiently than N-acetylmuramyl dipeptide and showed a stimulating effect on AFC production in the spleen of CBA mice. Springer US 2022-10-15 2022 /pmc/articles/PMC9568971/ /pubmed/36268163 http://dx.doi.org/10.1007/s11094-022-02724-w Text en © Springer Science+Business Media, LLC, part of Springer Nature 2022, Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Article
Baltina, L. A.
Baltina, L. A.
Petrova, S. F.
Gabdrakhmanova, S. F.
Makara, N. S.
Sapozhnikova, T. A.
Synthesis of Glycyrrhizic Acid Conjugates with Amino-Acid Methyl Esters and their Ability to Stimulate Antibody Genesis in Mice
title Synthesis of Glycyrrhizic Acid Conjugates with Amino-Acid Methyl Esters and their Ability to Stimulate Antibody Genesis in Mice
title_full Synthesis of Glycyrrhizic Acid Conjugates with Amino-Acid Methyl Esters and their Ability to Stimulate Antibody Genesis in Mice
title_fullStr Synthesis of Glycyrrhizic Acid Conjugates with Amino-Acid Methyl Esters and their Ability to Stimulate Antibody Genesis in Mice
title_full_unstemmed Synthesis of Glycyrrhizic Acid Conjugates with Amino-Acid Methyl Esters and their Ability to Stimulate Antibody Genesis in Mice
title_short Synthesis of Glycyrrhizic Acid Conjugates with Amino-Acid Methyl Esters and their Ability to Stimulate Antibody Genesis in Mice
title_sort synthesis of glycyrrhizic acid conjugates with amino-acid methyl esters and their ability to stimulate antibody genesis in mice
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9568971/
https://www.ncbi.nlm.nih.gov/pubmed/36268163
http://dx.doi.org/10.1007/s11094-022-02724-w
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