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Associations between serum mitokine levels and outcomes in stable COPD: an observational prospective study
Mitokines (Humanin (HN), GDF15 and FGF21) are produced as a result of mitochondrial dysfunction and may have major roles in chronic inflammation, malnutrition and exercise capacity in people with COPD. Except for GDF15, studies on this subject are lacking. A total of 165 patients with stable COPD an...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Nature Publishing Group UK
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9569360/ https://www.ncbi.nlm.nih.gov/pubmed/36243733 http://dx.doi.org/10.1038/s41598-022-21757-5 |
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author | Amado, Carlos A. Martín-Audera, Paula Agüero, Juan Lavín, Bernardo A. Guerra, Armando R. Muñoz, Pedro Berja, Ana Casanova, Ciro García-Unzueta, Mayte |
author_facet | Amado, Carlos A. Martín-Audera, Paula Agüero, Juan Lavín, Bernardo A. Guerra, Armando R. Muñoz, Pedro Berja, Ana Casanova, Ciro García-Unzueta, Mayte |
author_sort | Amado, Carlos A. |
collection | PubMed |
description | Mitokines (Humanin (HN), GDF15 and FGF21) are produced as a result of mitochondrial dysfunction and may have major roles in chronic inflammation, malnutrition and exercise capacity in people with COPD. Except for GDF15, studies on this subject are lacking. A total of 165 patients with stable COPD and 49 smokers without COPD were enrolled. We assessed their serum mitokine levels and clinical characteristics at baseline. We recorded moderate and severe exacerbation for the next 12 months. Baseline serum HN (p = 0.037) and GDF-15 (p = 0.013) levels were higher in the COPD group. High HN levels were independently associated with a high risk of exacerbation (HRE) (OR 2.798, 95% CI 1.266–6.187, p = 0.011), malnutrition (OR 6.645, 95% CI 1.859–23.749, p = 0.004), and 6MWD (OR 0.995, 95% CI 0.991–0.999, p = 0.008), and future moderate (HR 1.826, 95% CI 1.181–2.822, p = 0.007) and severe exacerbations (HR 3.445, 95% CI 1.357–8.740, p = 0.009). High GDF15 levels were associated with HRE (OR 3.028, 95% CI 1.134–8.083, p = 0.027), 6MWD (OR 0.995, 95% CI 0.990–0.999, p = 0.017) and predicted desaturation in 6MWT (OR 3.999, 95% CI 1.487–10.757, p = 0.006). High FGF21 levels were associated with HRE (OR 2.144, 95% CI 1.000–4.600, p = 0.05), and predicted future severe exacerbation (HR 4.217, 95% CI 1.459–12.193, p = 0.008). The mitokine levels were higher in patients with COPD than smokers without COPD, and were associated with important clinical outcomes such as exercise capacity and COPD exacerbation. Among the mitokines, HN showed the strongest association with COPD and may serve as a future risk biomarker in this disease. Trial registation NCT04449419. |
format | Online Article Text |
id | pubmed-9569360 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-95693602022-10-17 Associations between serum mitokine levels and outcomes in stable COPD: an observational prospective study Amado, Carlos A. Martín-Audera, Paula Agüero, Juan Lavín, Bernardo A. Guerra, Armando R. Muñoz, Pedro Berja, Ana Casanova, Ciro García-Unzueta, Mayte Sci Rep Article Mitokines (Humanin (HN), GDF15 and FGF21) are produced as a result of mitochondrial dysfunction and may have major roles in chronic inflammation, malnutrition and exercise capacity in people with COPD. Except for GDF15, studies on this subject are lacking. A total of 165 patients with stable COPD and 49 smokers without COPD were enrolled. We assessed their serum mitokine levels and clinical characteristics at baseline. We recorded moderate and severe exacerbation for the next 12 months. Baseline serum HN (p = 0.037) and GDF-15 (p = 0.013) levels were higher in the COPD group. High HN levels were independently associated with a high risk of exacerbation (HRE) (OR 2.798, 95% CI 1.266–6.187, p = 0.011), malnutrition (OR 6.645, 95% CI 1.859–23.749, p = 0.004), and 6MWD (OR 0.995, 95% CI 0.991–0.999, p = 0.008), and future moderate (HR 1.826, 95% CI 1.181–2.822, p = 0.007) and severe exacerbations (HR 3.445, 95% CI 1.357–8.740, p = 0.009). High GDF15 levels were associated with HRE (OR 3.028, 95% CI 1.134–8.083, p = 0.027), 6MWD (OR 0.995, 95% CI 0.990–0.999, p = 0.017) and predicted desaturation in 6MWT (OR 3.999, 95% CI 1.487–10.757, p = 0.006). High FGF21 levels were associated with HRE (OR 2.144, 95% CI 1.000–4.600, p = 0.05), and predicted future severe exacerbation (HR 4.217, 95% CI 1.459–12.193, p = 0.008). The mitokine levels were higher in patients with COPD than smokers without COPD, and were associated with important clinical outcomes such as exercise capacity and COPD exacerbation. Among the mitokines, HN showed the strongest association with COPD and may serve as a future risk biomarker in this disease. Trial registation NCT04449419. Nature Publishing Group UK 2022-10-15 /pmc/articles/PMC9569360/ /pubmed/36243733 http://dx.doi.org/10.1038/s41598-022-21757-5 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Amado, Carlos A. Martín-Audera, Paula Agüero, Juan Lavín, Bernardo A. Guerra, Armando R. Muñoz, Pedro Berja, Ana Casanova, Ciro García-Unzueta, Mayte Associations between serum mitokine levels and outcomes in stable COPD: an observational prospective study |
title | Associations between serum mitokine levels and outcomes in stable COPD: an observational prospective study |
title_full | Associations between serum mitokine levels and outcomes in stable COPD: an observational prospective study |
title_fullStr | Associations between serum mitokine levels and outcomes in stable COPD: an observational prospective study |
title_full_unstemmed | Associations between serum mitokine levels and outcomes in stable COPD: an observational prospective study |
title_short | Associations between serum mitokine levels and outcomes in stable COPD: an observational prospective study |
title_sort | associations between serum mitokine levels and outcomes in stable copd: an observational prospective study |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9569360/ https://www.ncbi.nlm.nih.gov/pubmed/36243733 http://dx.doi.org/10.1038/s41598-022-21757-5 |
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